The Effect of Giving Gel Combination of Binahong Leaf Extract and Turmeric Rhizome Extract on Histopathological Epithelial Thickness in II B Degree Burn of Rattus norvegicus
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This aim of this research was to study the effect of giving a combination gel of binahong (Anredera cordifolia) leaf and turmeric (Curcuma longa Linn) rhizome extract on histopathology of epithelial thickness which has II B degree burns. Twenty five male white rats (Rattus norvegicus) were divided into five groups. K(-) group was normal skin, K(+) group was skin burns treated with 1% silver sulfadiazine, P1, P2, and P3 was skin burns treated with gel combination of binahong leaf extract and turmeric rhizome extract with increase concentration of binahong leaf extract i.e. 1.25%, 2.5%, and 5%, while the concentration of turmeric rhizome extract i.e. 2% for each treatment. The combination gel of binahong leaf extrac 1.25% and turmeric rhizome extract 2% has potential to be an effective treatment for II B burns as indicated by increased of epithelial thickness. Therefore, this study concluded that 1.25% combination gel of binahong leaf extract and turmeric rhizome extract 2% is the effective dosage to increase epithelial thickness on II B healing degree burns wound healing.
Azaria, C., Achadiyani dan R. Farenia. 2017. Topical Effect of Pinneaple (Ananas comosus) Juice in Combustio Healing Process Measured by Granulation Process, Reepitelialisation and Angiogenesis. Journal of Medicine and Health. 1(5): 432-444.
Garmana, A.N., E.Y. Sukandar and I. Fidrianny. 2014. Activity of Several Plant Extracts Against Drug-Sensitive and Drug-Resistant Microbes. Procedia Chemistry. 13: 164-169.
Indraswary, R. 2014. Efek Konsentrasi Ekstrak Buah Adas (Foeniculum vulgare Mill.) Topikal pada Epitelisasi Penyembuhan Luka Gingiva Labial Tikus Sprague Dawley In Vivo [Skripsi]. Fakultas Kedokteran Gigi. Universitas Islam Sultan Agung.
Kagan, R.J., M.D. Peck, D.H. Ahrenholz, W.L. Hickerson., J. Holmes., R. Korentager., J. Kraatz., K. Pollock and G. Kotoski. 2013. Surgical Management of the Burn Wound and Use of Skin Substitutes: An Expert Panel White Paper. Journal of Burn Care and Research. 34(2): 60-79.
Kemenkes RI. 2018. Laporan Nasional Riset Kesehatan Dasar. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan Republik Indonesia. Jakarta. 256-257.
Kim, Y.S., I.H. Cho., M.J. Jeong., S.J. Jeong., S.Y. Nah.,Y.S. Cho., S.H. Kim., A.R. Go., S.E. Kim., S.S. Kang., C.J. Moon., J.C. Kim., S.H. Kim and C.S. Bae. 2011. Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing. Jurnal of Ginseng Research. 35(3): 360- 367.
Kurnianto, S. 2017. Efektivitas Ekstrak Daun Pangang (Centella asiatica) 25 % dengan Ekstrak Daun Petai Cina (Leucaena leucocephala) 30% terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus norvegicus) [Tesis]. Fakultas Keperawatan. Universitas Airlangga.
Kurnijasanti, R., D.K. Meles., S.A. Sudjarwo., T. Juniastuti dan I.S. Hamid. 2017. Buku Ajar Farmakoterapi dan Toksikologi. Cetakan 4. Duta Persada Press. Surabaya.
Lee, A.C. and H.K. Moon. 2003. Effect of Topically Applied Silver Sulfadiazine on Fibroblast Cell Proliferation and Biomechanical Properties of the Wound. Archives of Pharmacal Research. 26(10): 855-860.
Mehrabani, D., M. Farjam., B. Geramizadeh., N. Tanideh., M. Amini and M.R. Panjehshanin. 2015. The Healing Effect of Curcumin on Burn Wounds in Rat. Fasa University of Medical Sciences. 4(1): 29-35.
Nijveldt, R.J., E. Van Nood., D.E.C. Van Hoorn., P.G. Boelens., K. Van Norren and P.A.M. Van Leeuwen. 2001. Flavonoids: a review of probable mechanisms of action and potential applications. The American Journal of Clinical Nutrition. 74(4): 418-425.
Paju, N., P.V.Y. Yamlean dan N. Kojong. 2013. Uji Efektivitas Salep Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) pada Kelinci (Oryctolagus cuniculus) yang Terinfeksi Bakteri Staphylococcus aureus. Jurnal Ilmiah Farmasi Unsrat. 2(1): 51-61.
Palumpun, E.F., A.A.G.P. Wiraguna dan W. Pangkahila. 2017. Pemberian Ekstrak Daun Sirih (Piper betle) secara Topikal Meningkatkan Ketebalan Epidermis, Jumlah Fibroblas, dan Jumlah Kolagen dalam Proses Penyembuhan Luka pada Tikus Jantan Galur Wistar (Rattus norvegicus). Jurnal e-Biomedik. 5(1).
Paramita, A. 2016. Pengaruh Pemberian Salep Ekstrak Daun Binahong (Anredera cordifolia (Ten) Steenis) terhadap Kepadatan Kolagen Tikus Putih (Rattus norvegicus) yang Mengalami Luka Bakar [Skripsi]. Fakultas Kedokteran Hewan. Universitas Airlangga. 40.
Saeidinia, A., F. Keihanian., A.P. Lashkari., H.G. Lahiji., M. Mobayyen., A. Heidarzade and J. Golchai. 2017. Partial-Thickness Burn Wounds Healing by Topical Treatment: A Randomized Controlled Comparison Between Silver Sulfadiazine and Centiderm. Medicine. 96(9): 1-9.
Suryaningtyas, I.F.A. 2019. The Effect of Gel Combination of Binahong Leaf Extract and Turmeric Rhizome Extract on the Mature Collagen Density of Rats which Have II B Degree Burns [Skripsi]. Fakultas Kedokteran Hewan. Universitas Airlangga.
Thangapazham, R.L., S. Sharad and R.K. Maheshwari. 2013. Review Article Skin Regenerative Potentials of Curcumin. 3 International Union of Biochemistry and Molecular Biology. 39(1): 141-149.
Theresia, S.W. 2019. The Effect of Madeira Vine Leaf Extract (Anredera cordifolia (Ten.) Steenis) Combined With Turmeric Rhizome Extract (Curcuma longa) Gel Given Topically to II B Burn Wound of White Rat (Rattus norvegicus) on Fibroblast Number [Skripsi]. Fakultas Kedokteran Hewan. Universitas Airlangga.
Wientarsih, I., W. Winarsih dan L.N. Sutardi. 2012. Aktivitas Penyembuhan Luka oleh Gel Fraksi Etil Asetat Rimpang Kunyit pada Mencit Hiperglikemik. Jurnal Veteriner. 13(3): 251-256.
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