Efek Analgesik Ekstrak Etanol Zingiber cassumunar Roxb. pada Mencit dengan Metode Writhing Test
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Penelitian bertujuan untuk menguji efek analgesik ekstrak etanol Zingiber cassumunarRoxb. pada mencit yang diinduksi dengan asam asetat.Penelitian ini merupakan penelitian eksperiment posttest only control design, menggunakan metode writhing test. Sampel penelitian terdiri dari 25 mencit terbagi dalam tiga kelompok perlakuan ekstrak Zingiber cassumunar Roxb.; P1, P2, dan P3, dengan masing-masing dosis 100 mg/kgBB, 200 mg/kgBB, 400 mg/kgBB, kelompok kontrol negatif aquades (K-), serta kelompok kontrol positif aspirin (K+). Hasil penelitian menunjukkan bahwa (P1) dan (P2) signifikan menurunkan jumlah geliat pada mencit dibandingkan (K-) (p < 0,05), dengan persentase penurunan jumlah geliat sebesar 49,53% dan 57,01%, sedangkan (P3) tidak menunjukkan aktivitas analgesik. Ekstrak Zingiber cassumunar Roxb. dosis 100 mg/kgBB dan 200 mg/kgBB tidak memiliki perbedaan yang signifikan terhadap (K+) untuk mengurangi rasa nyeri.
Arafah, E., Muchtadi, D., Zakaria, F.R., Wresdiyati, T., Sidik. 2004. Protective Effect of Bangle (Zingiber cassumunar Roxb.) Rhizome Extract on CCL4-Induced Liver Damage of Rats. Indon. Assoc. Food Technol., 15(3), 214-220.
Astuti, T.B., 2013. Uji Aktivitas Antimikroba Ekstrak Etanol 70% Rimpang Bangle (Zingiber purpureum Roxb.) terhadap Bakteri Staphylococcus aureus ATCC 25925 dan Jamur Microsporum canis secara in vitro. [Skripsi]. Fakultas Kedokteran dan Ilmu Kesehatan. UIN Syarif Hidayatullah Jakarta.
Aupaphong, V., Ayudhya, T.D.N., Koontongkaew, S. 2012. Inhibition of Lipopolysaccharide-induced Expression of Cyclooxygenase-2 by Zingiber cassumunar Roxb. Constituents in Human Dental Pulp Cells. J. Med. Plants Res., 7(33), 2451-2458.
Cooper, S.A., Voelker, M. 2012. Evaluation of Onset Pain Relief from Micronized Aspirin in a Dental Pain Model. Inflammopharmacol., 20(4), 233-242.
Das, M., Gohain, K., Das, S. 2017. Evaluation of Central and Peripheral Analgesic Activities of Solanum melongena Ethanolic Leaf Extract in Experimental Animals. Int. J. Pharm. Sci. Res., 22, 1168-1172.
Elzahaf, R.A, Tashani, O.A., Unsworth, B.A., Johnson M.I. 2012. The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9 : a systematic review without meta-analysis. Curr. Med. Res. Opinion, 28(7), 1221-1229.
Golan , D. E., Armstrong, E.J., Armstrong, A.W. 2017. Principles of Pharmacology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, p264-267.
Guyton, A.C., Hall, J.E. 2011. Guyton dan Hall Buku Ajar Fisiologi Kedokteran. 12th ed. Singapore: Elsevier Saunders, p583-585.
Hämäläinen, M., Nieminen, R., Asmawi, M., Vuorela, P., Vapaatalo, H., Moilanen, E. 2011. Effects of Flavonoids on Prostaglandin E2 Production and on COX-2 and mPGES-1 Expressions in Activated Macrophages. Planta Medica, 77(13), 1504–1511.
Hitner, H., Nagle, B. 2012. Pharmacology : An Introduction. 6th ed. New York : McGraw-Hill, p296-298.
International Association for the Study of Pain, 2017, Updated IASP Terminology. [Online]. https://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1698
Kato, E., Kubo, M., Okamoto, Y., Matsunaga, Y., Kyo, H., Suzuki, N., , Uebaba, K., Fukuyama, Y. 2018. Safety Assessment of Bangle (Zingiber purpureum Rosc.) Rhizome extract: Acute and Chronic Studies in Rats and Clinical Studies in Human. ACS Omega , 3(11), 15879-15889.
Koontongkaew, S., Poachanukoon, O., Sireeratawong, S., Ayudhya, T.D.N., Khonsung, P., Jaijoy, K., Soawakontha, R., Chanchai, M. 2014. Safety Evaluation of Zingiber cassumunar Roxb. Rhizome Extract: Acute and Chronic Toxicity Studies in Rats. International Scholarly Research Notices, 2014.
Koparde, A.A., Magdum, C.S. 2017. Analgesic Activity of Extracts of Eulophia ochreata Lindl. and Zingiber cassumunar Roxb. in Animal Model. Int. J. Pharm. Sci. Res., 29, 1956-1962.
Manimmanakorn, N., Manimmanakorn, A., Boobphachart, D., Thuwakum, W., Laupattarakasem, W., Hamlin, M.J. 2016. Effect of Zingiber cassumunar (Plai cream) in the treatment of delayed onset muscle soreness. J. Integrat. Med., 14(2), 114-120.
Milind, P., Monu, Y. 2012. Laboratory Models for Screening Analgesics. Int. Res. J. Pharm., 4(1), 15-19.
Pudjiastuti, N.H. 1999. Penelusuran Beberapa Tanaman Obat Berkhasiat Sebagai Analgetik. Media Litbang Kes., 9(3).
Setyawati, E. 2012. Evaluasi Penggunaan Obat Analgetik Antipiretik sebagai Upaya Pengobatan Sendiri di Kelurahan Pondok Karanganom Klaten. [Skripsi]. Fakultas Farmasi. Universitas Muhammadiyah Surakarta.
Suryani, N.C., Permana, D.G.M., Jambe, A.A.G.N.A. 2016. Pengaruh Jenis Pelarut terhadap Kandungan Total Flavonoid dan Aktivitas Antioksidan Ekstrak Daun Matoa (Pometia pinnata). [Skripsi]. Universitas Udayana.
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