A Systematic Review of Supportive Therapy Effect on Quality of Life in Cancer Patients

Suharyono Suharyono, Suhendra Agung Wibowo, Ira Purnamasari, Tintin Sukartini

= http://dx.doi.org/10.20473/jn.v15i2.19013
Abstract views = 306 times | downloads = 124 times


Introduction: Supportive therapy is considered an important element in the treatment of cancer patients which is often associated with efforts to overcome life-threatening problems. However, the application of this intervention in clinical practice has not yet been fully carried out. This systematic review summarizes the evidence regarding the effect of supportive therapy in improving the quality of life (QoL) of cancer patients.

Methods: The review was performed according to PRISMA guidelines. We searched four electronic databases to identify studies comparing patients who received specific protocol interventions with the control group. The keywords used are "Supportive Therapy" AND "Palliative Supportive Care" AND "Quality of Life" OR "Health Quality" OR "Health-Related Quality of Life".

Results: In the study, the average quality of life assessment was carried out at 12 weeks and six months after the intervention. Seven7 of the 15 studies used QLQ-C30 to measure the quality of life of patients with cancer, which was managed to validate and assess the quality of life in patients with cancer, whereas of the 15 studies evaluating results reported, patients reported differences in favor of the intervention group.

Conclusion: The overall methodology quality is good. Several comparative studies have evaluated the impact of supportive therapy on the quality of life of cancer patients. The quality of this study is good and the results are acceptable in improving the quality of life of cancer patients undergoing chemotherapy treatment, and palliative care.


supportive therapy; quality of life (QoL); cancer patients

Full Text:



A. Shrestha, K., Collins, C., Martin, M. Burton, S., Walters., and L. Wyld. (2019). Quality of life versus length of life considerations in cancer patients : A systematic literature review,” no. May 2018, pp. 1367–1380

Baryam, Z., Durna, Z., & Akin, S. (2014). Quality of life during chemotherapy and satisfaction with nursing care in Turkish breast cancer patients. European Journal of Cancer Care, 23,675-684.doi: 10.1111/ecc.12185

Blanco, C., Markowitz, J. C., Hellerstein, D. J., Nezu, A. M., Wall, M., Olfson, M., … Hershman, D. L. (2019). A randomized trial of interpersonal psychotherapy, problem solving therapy, and supportive therapy for major depressive disorder in women with breast cancer. Breast Cancer Research and Treatment, 173(2), 353–364. https://doi.org/10.1007/s10549-018-4994-5

Breitbart, W., Pessin, H., Rosenfeld, B., Applebaum, A. J., Lichtenthal, W. G., Li, Y., … Fenn, N. (2018). Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: A randomized controlled trial in patients with advanced cancer. Cancer, 124(15), 3231–3239. https://doi.org/10.1002/cncr.31539

C. Fernández-rodríguez, E. Villoria-fernández, P. Fernández-garcía, and S. González-fernández. (2017). Effects of Behavioral Activation on the Quality of Life and Emotional State of Lung Cancer and Breast Cancer Patients During Chemotherapy Treatment

Chang, Y. L., Tsai, Y. F., Hsu, C. L., Chao, Y. K., Hsu, C. C., & Lin, K. C. (2020). The effectiveness of a nurse-led exercise and health education informatics program on exercise capacity and quality of life among cancer survivors after esophagectomy: A randomized controlled trial. International Journal of Nursing Studies, 101, 103418. https://doi.org/10.1016/j.ijnurstu.2019.103418

Chang, Y.L., Tsai, Y.F., Chao, Y.K., Wu, M.Y. (2016). Quality-of-life measures as predictorss of post-esophagectomy survival of patients with esophageal cancer. Qual. Life Res. 25 (2), 465–475. doi: 10.1007/s11136- 015- 1094- 4

Chasen, M.R., Bhargava, R. (2010). A rehabilitation program for patients with gastroesophageal cancer –a pilot study". Support Care Cancer 18 (2), S35–S40. doi: 10.10 07/s0 0520- 010- 0828- 7

Duluklu, B., & Çelik, S. Ş. (2019). Effects of lavender essential oil for colorectal cancer patients with permanent colostomy on elimination of odor, quality of life, and ostomy adjustment: A randomized controlled trial. European Journal of Oncology Nursing, 42(March), 90–96. https://doi.org/10.1016/j.ejon.2019.08.001

Downs SH, Black N. (2016). The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998;52:377-84

Foster, C., Wright, D., Hill, H., Hopkinson, J., & Roffe, L. (2009). Psychosocial implications of living 5 years or more following a cancer diagnosis: A systematic review of the research evidence". European Journal of Cancer Care, 18, 223-247. doi:10.1111/j.1365-2354.2008.01001.x

Gok Metin, Z., Karadas, C., Izgu, N., Ozdemir, L., & Demirci, U. (2019). Effects of progressive muscle relaxation and mindfulness meditation on fatigue, coping styles, and quality of life in early breast cancer patients: An assessor blinded, three-arm, randomized controlled trial. European Journal of Oncology Nursing, 42(September), 116–125. https://doi.org/10.1016/j.ejon.2019.09.003

Hughes, S., Jaremka, L. M., Alfano, C. M., Glaser, R., Povoski, S. P., Lipari, A. M., Malarkey, W. B. (2014). Social support predicts inflammation, pain, and depressive symptoms: Longitudinal relationships among breast cancer survivors". Psychoneuroendocrinology, 42, 38-44. doi:10.1016/j.psyneuen. 2013.12.016

Jefford, M., Gough, K., Drosdowsky, A., Russell, L., Aranda, S., Butow, P., … Schofield, P. (2016). A Randomized Controlled Trial of a Nurse-Led Supportive Care Package (SurvivorCare) for Survivors of Colorectal Cancer. The Oncologist, 21(8), 1014–1023. https://doi.org/10.1634/theoncologist.2015-0533

Klafke, N., Mahler, C., von Hagens, C., Uhlmann, L., Bentner, M., Schneeweiss, A., … Joos, S. (2019). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial. Cancer Medicine, 8(8), 3666–3676. https://doi.org/10.1002/cam4.2196

Kershaw, T., Northouse, L., Kritpracha, C., Schafenacker, A., Mood, D., Coping strategies and quality of life in women with advanced breast cancer and their family caregivers. Psychol. Health 19 (2), 139–155, 2004.

Klafke, N., Mahler, C., von Hagens, C., Uhlmann, L., Bentner, M., Schneeweiss, A., … Joos, S. (2019). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial. Cancer Medicine, 8(8), 3666–3676. https://doi.org/10.1002/cam4.2196

Lake, B., Fuller, H.R., Rastall, S., Usman, T. (2019). Breast reconstruction affects coping mechanisms in breast cancer survivors". Indian J. Surg. 81 (1), 43–50.

Maguire, R., Kotronoulas, G., Simpson, M., & Paterson, C. (2015). Gynecologic Oncology A systematic review of the supportive care needs of women living with and beyond cervical cancer. Gynecologic Oncology, 136(3), 478–490. http://doi.org/10.1016/j.ygyno. 2014.10.030

Malmström, M., Ivarsson, B., Klefsgård, R., Persson, K., Jakobsson, U., & Johansson, J. (2016). The effect of a nurse led telephone supportive care programme on patients’ quality of life, received information and health care contacts after oesophageal cancer surgery—A six month RCT-follow-up study. International Journal of Nursing Studies, 64, 86–95. https://doi.org/10.1016/j.ijnurstu.2016.09.009

Pace, T. W. W., Dodds, S. E., Sikorskii, A., Badger, T. A., Segrin, C., Negi, L. T., … Crane, T. E. (2019). Cognitively-Based Compassion Training versus cancer health education to improve health-related quality of life in survivors of solid tumor cancers and their informal caregivers: Study protocol for a randomized controlled pilot trial. Trials, 20(1), 1–15. https://doi.org/10.1186/s13063-019-3320-9

Qiu, Y., You, J., Wang, K., Cao, Y., Hu, Y., Zhang, H., … Lyu, Q. (2020). Effect of whole-course nutrition management on patients with esophageal cancer undergoing concurrent chemoradiotherapy: A randomized control trial. Nutrition, 69, 1–9. https://doi.org/10.1016/j.nut.2019.110558

Schuit, A. S., Holtmaat, K., Hooghiemstra, N., Jansen, F., Lissenberg-Witte, B. I., Coupé, V. M. H., … Verdonck-De Leeuw, I. M. (2019). Efficacy and cost-utility of the eHealth application “Oncokompas”, supporting patients with incurable cancer in finding optimal palliative care, tailored to their quality of life and personal preferences: A study protocol of a randomized controlled trial. BMC Palliative Care, 18(1), 1–11. https://doi.org/10.1186/s12904-019-0468-8

Temel, J. S., Greer, J. A., El-Jawahri, A., Pirl, W. F., Park, E. R., Jackson, V. A., … Ryan, D. P. (2017). Effects of early integrated palliative care in patients with lung and gi cancer: A randomized clinical trial. Journal of Clinical Oncology, 35(8), 834–841. https://doi.org/10.1200/JCO.2016.70.5046

Uster, A., Ruehlin, M., Mey, S., Gisi, D., Knols, R., Imoberdorf, R., … Ballmer, P. E. (2017). Effects of nutrition and physical exercise intervention in palliative cancer patients : A randomized controlled trial. Clinical Nutrition, (June), 1–8. https://doi.org/10.1016/j.clnu.2017.05.027

Vanbutsele, G., Van Belle, S., Surmont, V., De Laat, M., Colman, R., Eecloo, K., … Pardon, K. (2020). The effect of early and systematic integration of palliative care in oncology on quality of life and health care use near the end of life: A randomised controlled trial. European Journal of Cancer, 124, 186–193. https://doi.org/10.1016/j.ejca.2019.11.009

Zhou, K., Wang, D., He, X., Huo, L., An, J., Li, M., … Li, X. (2016). Effectiveness of a multimodal standard nursing program on health-related quality of life in Chinese mainland female patients with breast cancer: Protocol for a single-blind cluster randomized controlled trial. BMC Cancer, 16(1), 1–8. https://doi.org/10.1186/s12885-016-2726-y

Zhou, Y., Cartmel, B., Gottlieb, L., Ercolano, E. A., Li, F., Harrigan, M., … Irwin, M. L. (2017). Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC). Journal of the National Cancer Institute, 109(12), 1–7. https://doi.org/10.1093/jnci/djx072


  • There are currently no refbacks.

Copyright (c) 2020 Jurnal Ners

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This journal is indexed by:





This journal is published by:


          Faculty of Nursing Universitas Airlangga in Collaboration with Indonesian National Nurses Association


Creative Commons License

This journal (p-ISSN:1858-3598; e-ISSN:2502-5791) is licensed under a Creative Commons Attribution 4.0 International License


Current Stats

Previous Stats