Comparison of The Effectiveness Between Propolis and Silver Sulfadiazine 1% on Burn Wound Healing
Downloads
Introduction: Silver sulfadiazine 1% is often used as topical agent in burn wound due to its antimicrobial effect. Moreover, this agent has toxigenic effect on fibroblast and keratinocyte. Propolis is a honey bee product and has been used for a long time in burn wound related to antimicrobial effect, anti-inflammation, anti-oxidant and increasing fibroblast. The purpose of this study was to examining the differences between propolis and silver sulfadiazine 1% on burn wound healing process.
Method:Design used in this study was true experimental design. The samples were 18 guinea pigs divided randomizely into three group. The groups were control group, propolis group, and silver sulfadiazine group. The independent variables were the using of propolis and silver sulfadiazine 1%. The dependent variables were inflammation phase (erythema, oedema, wound fluid) and proliferation phase (wound granulation, wound size) which were observed on the 3rd, 7th, 14th days. Data were collected by using observation paper based on the sign of inflammation and proliferation. Data were analyzed using One-Way ANOVA and Kruskal-wallis test with level of significance of α ≤ 0.05.
Result:Results showed that there were differences between propolis and silver sulfadiazine 1% in erythema (p=0.00) and oedema (p=0.001) on 3rd day and erythema (p=0.00) and oedema (p=0.00) on7th day, furthermore burn wound size (p=0.00) on14th day was also attenuated by propolis and silver sulfadiazine 1 %. It can be concluded that the using of propolis was more effective than silver sulfadiazine 1% in burn wound healing.
Discussion: Further studies involved microscopic observation of collagen, PMN cell (neutrophile), lymphocyte and monocyte cell are needed.
Afrina, N., 2009. Perbedaan Efektivitas Antara Propolis dan Madu Lebah untuk Mempercepat Hilangnya Eritema pada Luka Bakar Derajat II Dalam pada Tikus Putih (Rattus norvegicus) Galur Wistar. Skripsi tidak dipublikasikan. Malang: PSIK FK Universitas Brawijaya.
Almeida, A,.& Noronha, C., 2000. Local Burn Treatment-Topical Antimicrobial Agents. Annuals of Burns and Fire Disasters, 13 (4), pp. 216-219.
Atiyah, B., Michael C & Shady W. H, 2007. Effect of Silver on Burn Wound Infection Control and Healing: Review of Literatur. Burns, 33, pp.139-148.
Brunicardi, C, 2005. Schwartz's Principles of Surgery. New York: McGraw-Hill Companies, pp: 190-191 dan 224-330
Cho L, et al., 2005. Reversal of Silver Sulfadiazine Impaired Wound Healing by Epidermal Growth Factor. Journal of Biomaterilas, 26, pp. 4670-4676.
Authors who publish with Jurnal Ners agree to the following terms:
- Authors transfer the Copyright and grant Jurnal Ners the right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Jurnal Ners.
- Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Ners.
Jurnal Ners requires a formal written declaration and transfer of copyright from the author(s) for each article published. We, therefore, ask you to complete and return this form, retaining a copy for your own records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication. The form can be downloaded HERE.
