Risk Factors and Challenging Management of Lung Adenocarcinoma in Young Adult Women: Case Series
Introduction: Lung cancer found in young age is relatively rare with a percentage of cases only 1.4% of overall lung cancer cases in the world.
Case: We reported two cases of lung adenocarcinoma in young women aged less than 30. The first case was lung adenosquamous carcinoma in a 28-year-old woman, a passive smoker, who had a family history of cancer. She had the mutation of epidermal growth factor receptor (EGFR) exon 19 deletion and received 1st generation of tyrosine kinase inhibitor. Since the patient was diagnosed at advanced stage with poor performance status, she died within 2 months after being diagnosed. The second case was lung adenocarcinoma in a 23-year-old woman. The patient was a passive smoker and had a history of cancer in the family. She was diagnosed at an advanced stage but with good performance status. The patient underwent chemotherapy with Pemetrexed-Platinum in 6 cycles and 15 cycles of radiotherapy.
Conclusion: Lung cancer at a young age is more common in non-smoking female with the histopathology type adenocarcinoma. Non-specific early symptoms become a problem in the early enforcement of lung cancer at a young age. Many cancer-related issues occur in young cancer patient such as premature death, increased dependence on parents, difficulty in school and work due to medication, and reproductive disturbance.
Institute NC. Cancer Stat Facts: Lung and Bronchus Cancer. Surveillance, Epidemiology, and End Results (SEER), https://seer.cancer.gov/statfacts/html/lungb.html (2022, accessed 21 May 2022).
Gupta S, Harper A, Ruan Y, et al. International Trends in the Incidence of Cancer Among Adolescents and Young Adults. J Natl Cancer Inst 2020; 112: 1105–1117.
Liu B, Quan X, Xu C, et al. Lung Cancer in Young Adults Aged 35 Years or Younger: A Full-Scale Analysis and Review. J Cancer 2019; 10: 3553–3559.
Fidler-Benaoudia MM, Torre LA, Bray F, et al. Lung Cancer Incidence in Young Women vs. Young Men: A Systematic Analysis in 40 Countries. Int J Cancer 2020; 147: 811–819.
Viñal D, Martínez D, Higuera O, et al. Genomic Profiling in Non-Small-Cell Lung Cancer in Young Patients. A Systematic Review. ESMO Open 2021; 6: 100045.
Shi J, Li D, Liang D, et al. Epidemiology and Prognosis in Young Lung Cancer Patients Aged Under 45 Years Old in Northern China. Sci Rep 2021; 11: 6817.
Tanaka K, Hida T, Oya Y, et al. Unique Prevalence of Oncogenic Genetic Alterations in Young Patients with Lung Adenocarcinoma. Cancer 2017; 123: 1731–1740.
Chen L, Hu X, Wu H, et al. Unique Profiles of Targetable Genomic Alterations and Prognosis in Young Chinese Patients with Lung Adenocarcinoma. Pathol - Res Pract 2019; 215: 152407.
Hou H, Zhu H, Zhao H, et al. Comprehensive Molecular Characterization of Young Chinese Patients with Lung Adenocarcinoma Identified a Distinctive Genetic Profile. Oncologist 2018; 23: 1008–1015.
Ragavan M, Patel MI. The Evolving Landscape of Sex-Based Differences in Lung Cancer: A Distinct Disease in Women. Eur Respir Rev; 31. Epub ahead of print March 2022. DOI: 10.1183/16000617.0100-2021.
Stapelfeld C, Dammann C, Maser E. Sex-Specificity in Lung Cancer Risk. Int J Cancer 2020; 146: 2376–2382.
Araujo JM, Rosas G, Belmar-López C, et al. Influence of Sex in the Molecular Characteristics and Outcomes of Malignant Tumors. Front Oncol 2021; 11: 752918.
Sansom-Daly UM, Wakefield CE, Signorelli C, et al. Patterns and Predictors of Healthcare Use among Adolescent and Young Adult Cancer Survivors versus a Community Comparison Group. Cancers (Basel); 13. Epub ahead of print October 2021. DOI: 10.3390/cancers13215270.
Janardan SK, Wechsler DS. Caught in the In-Between: Challenges in Treating Adolescents and Young Adults with Cancer. JCO Oncology Practice 2021; 17: 299–301.
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