Sticky Fibrin Adhesion: Enlightenment from a Case of Tuberculous Pleurisy
Downloads
Introduction: Tuberculous pleurisy (TP) is the pleural inflammation caused by Mycobacterium tuberculosis (MTB) and a rare manifestation of childhood tuberculosis (TB). It is characterized by a large amount of fibrin, sticky adhesion, and even calcification. Pleural adhesion can significantly affect respiratory function and quality of life. Therefore, early detection, prompt therapy, and drainage of pleural effusion are crucial for preventing pleural adhesion. This case report is intended to enhance clinician awareness regarding avoiding and managing pleural thickening in TP.
Case: A 14-year-old child had shortness of breath, fever for 2 weeks, cough, loss of appetite, and no smoking history. The laboratory results showed anemia and non-reactive human immunodeficiency viruses (HIV), analyzed pleural fluid monocyte showed 72%, and glucose 58%. Adenosine deaminase (ADA) analysis showed a rise above 61 U/L. The tuberculin skin test was negative. The chest X-ray showed right pleural effusion, the chest ultrasonography revealed a right hemithorax echo-free plane, and the computed tomography (CT) scan showed right pleural effusion and pulmonary fibrosis. The thoracoscopy view showed fibrinous adhesion-producing tenting and vascularization in the base without multiple nodules. Water-sealed drainage was performed and produced approximately 3,450 ml with serous xanthochromia. Then the patient was diagnosed with TP and treated with anti-TB drugs and steroids.
Conclusion: Typical TP with fibrinous adhesions is an infrequent condition. This case report highlighted the importance of extensive screening using a thoracoscopy view and ADA analysis in patients with TP, especially in countries with a high TB burden.
World Health Organization (WHO). Global Tuberculosis Report 2022. Geneva, https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022 (2022).
Lunelli M, Ferreira I, Sarmento M, et al. Pleural Tuberculosis in Children and Adolescents: A Difficult Diagnosis? 2021. Epub ahead of print 7 January 2021. [ResearchGate]
Shah A, Gurnani S. Clinical Profile of Tuberculous Pleural Effusion in Children. Pediatr Oncall; 19. Epub ahead of print 1 January 2022. [Journal]
Marais BJ, Verkuijl S, Casenghi M, et al. Paediatric Tuberculosis”New Advances to Close Persistent Gaps. Int J Infect Dis 2021; 113: S63–S67. [PubMed]
Poznyak AV, Bezsonov EE, Popkova TV, et al. Vaccination against Atherosclerosis: Is It Real? Int J Mol Sci; 23. Epub ahead of print February 2022. [PubMed]
Gopalaswamy R, Dusthackeer VNA, Kannayan S, et al. Extrapulmonary Tuberculosis”An Update on the Diagnosis, Treatment and Drug Resistance. Journal of Respiration 2021; 1: 141–164. [Journal]
Wang J-L, Zhou M, Zhang Y-A, et al. Loculations and Associated Risk Factors of Childhood Pleural Tuberculosis. Front Pediatr 2021; 9: 781042. [PubMed]
Rakesh HR, Gelzinis TA. The Updated ATS/STS/STR Clinical Practice Guidelines on the Management of Malignant Pleural Effusions: What is New in 2018? Journal of Cardiothoracic and Vascular Anesthesia 2019; 33: 1181–1186. [PubMed]
Lo Cascio CM, Kaul V, Dhooria S, et al. Diagnosis of Tuberculous Pleural Effusions: A Review. Respir Med 2021; 188: 106607. [PubMed]
Chiner E, Nomdedeu M, Vañes S, et al. Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain. J Clin Med; 10. Epub ahead of print September 2021. [PubMed]
Lunelli M, Ferreira ICS, Sarmento MB, et al. Pleural Tuberculosis: Experiences from Two Centers in Brazil. J Pediatr (Rio J) 2022; 98: 621–625. [PubMed]
Yang X, Che N, Duan H, et al. Cell-Free Mycobacterium tuberculosis DNA Test in Pleural Effusion for Tuberculous Pleurisy: A Diagnostic Accuracy Study. Clin Microbiol Infect 2020; 26: 1089.e1-1089.e6. [PubMed]
Yurt S, Küçükergin C, Yigitbas BA, et al. Diagnostic Utility of Serum and Pleural Levels of Adenosine Deaminase 1-2, and Interferon-γ in the Diagnosis of Pleural Tuberculosis. Multidiscip Respir Med 2014; 9: 12. [PubMed]
Zhu Y, Gao Y-H, Zou J-N, et al. Beware of Pleural Thickening and Calcification: An Enlightenment from a Case of Tuberculous Pleurisy. Risk Management and Healthcare Policy 2021; 14: 1551–1554. [PubMed]
McNally E, Ross C, Gleeson LE. The Tuberculous Pleural Effusion. Breathe 2023; 19: 230143. [Journal]
Antonangelo L, Faria CS, Sales RK. Tuberculous Pleural Effusion: Diagnosis & Management. Expert Rev Respir Med 2019; 13: 747–759. [PubMed]
Shaw JA, Diacon AH, Koegelenberg CFN. Tuberculous Pleural Effusion. Respirology 2019; 24: 962–971. [PubMed]
Aggarwal AN, Agarwal R, Dhooria S, et al. Pleural Fluid Interleukins for Diagnosis of Tuberculous Pleural Effusion: A Systematic Review and Meta-Analysis. Cytokine 2022; 159: 156019. [PubMed]
Shao R-J, Du M-J, Xie J-T. Use of Lung Ultrasound for the Diagnosis and Treatment of Pleural Effusion. Eur Rev Med Pharmacol Sci 2022; 26: 8771–8776. [PubMed]
Liu X-T, Dong X-L, Zhang Y, et al. Diagnostic Value and Safety of Medical Thoracoscopy for Pleural Effusion of Different Causes. World J Clin Cases 2022; 10: 3088–3100. [PubMed]
Copyright (c) 2024 Budi Yanti, Bakhtiar Bakhtiar, Jamalul Azizi
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions.
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
4. The Creative Commons Attribution Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violation.