Difference Between Bone Healing Process with The Use Of Demineralized Freeze Dried Bone Xenograft and Bovine Bone Hydroxyapatite Xenograft Materials

Zefry Zainal Abidin

doi:10.20473/jscrte.v5i2.33149

Authors

Zefry Zainal Abidin
zefryzabidin@gmail.com
Faculty of Dentistry, Airlangga University

Vol. 5 No. 2 (2021): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING

Articles

January 26, 2022

Downloads

PDF

Abstract
How to Cite
Metrics
References
License

Autogenous bone graft is the gold standard for bone defects treatment, however due to their limitation and the donor site morbidity may caused many surgeons use a xenograft type of bone grafting to cope the problem. Demineralized Freeze Dried Bone Xenograft (DFDBBX) which contains of growth factors, have a good biocompatibility. The aim of this study is observed the difference in bone healing processes between DFDBBX and Bovine Bone Hydroxyapatite Xenograft (BBHAX). Bicortical bone defects were created in the mandibular corpus of 30 New Zealand White Rabbits. The groups were divided into 3 groups which the first group were treated with DFDBBX into the hole and the negative control group was left perforated. The other group was treated with BBHAX. All group were evaluated after second and fourth weeks to count the ammount of osteoblast, osteoclast cells, Collagen-1 (Coll-1) and alkalin phosphatase (ALP). The second week of observation showed a significant difference of mean 12,45, SD 2,97 (p<0,05) in osteoblast cells. In Coll-1 showed with mean 13,2 SD 2,68 (p<0,05). The result of ALP showed with mean 14,6 SD 2,70 (p<0,05). In the the fourth week observation showed increased of osteoclast cells with mean 7,043, SD 2,77 (p< 0,05) and for Coll-1 with mean 17,6, SD 2,30 (p< 0,05). DFDBBX showed more effective in treating bone defects of mandible of new zealand white rabbits in second week of observation.

Aql, Z., Alagl, A., Graves, D., Gerstenfield, L., & Einhorn, T. (2008). Molecular Mechanisms Controlling Bone Formation During Fracture Healing and Distraction Osteogenesis. Journal Dent Res, 87(2), 108–118.

Barradas, A., Yuan, H., Blitterswijk, C. A. V, & Habibovie, P. (2011). Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms. European Cells and Materials, 21 2012, 407–429.

Birmingham, E., Niebul, G., McHugh, P., Shaw, G., Barry, F., & McNamara, L. (2012). Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche. European Cells and Materials, 23 2012, 13–27.

Buckwalter, J. (2008). Orthopaedic Basic Science Biology and Biomechanics of the Musculoskletal System. American Academy of Orhopaedic Surgeon 2nd Edition, 372–395.

Buser, D. (2009). 20 Years of Guided Bone Regeneration in Implant Dentistry 2nd ed. Quintessence Publishing Company.

Cohen, R., Mullarky, R., Noble, B., Comeau, R., & Neiders, M. (1994). Phenotypic characterisation of mononuclear cells following anorganic bovine bone implantation in rats. Journal Periodontal, 65, 1008–1015.

Farzad, M., & Mohammadi. (2012). Guided bone regeneration: a literature review. Johoe 1, 1, 3–18.

Ferdiansyah. (2007). Use of freeze-dried Iiradiated Bones in Orthopaedic Surgery. In Radiation in Tissue Banking Basic Science and Clinical Applications of Radiated Tissue Allograft. World Scientific Singapore, 317–326.

Ferdiansyah, M., Utomo, D. N., Suroto, H., Martanto, T. W., Edward, M., & Gaol, I. L. (2017). Comparative Effectiveness of Bone Grafting Using Xenograft Freeze-Dried Cortical Bovine, Allograft Freeze-Dried Cortical New Zealand White Rabbit, Xenograft Hydroxyapatite Bovine, and Xenograft Demineralized Bone Matrix Bovine in Bone Defect of Femoral Di. International Journal of Biomaterials, 2017.

Ferdiansyah, Utomo, D. N., Suroto, H., & Gaol, I. L. (2017). Immunogenicity of Bone Graft Using Xenograft Freeze-Dried Cortical Bovine, Allograft Freeze-Dried Cortical New Zealand White Rabbit, Xenograft Hydroxyapatite Bovine, And Xenograft Demineralized Bone Matrix Bovine In Bone Defect Of Femoral Diaphysis White. The Veterinary Medicine International Conference KnE Life Sciences, 344–355.

Hallman, M., & Thor, A. (2008). Bone Substitutes and Growth Factors as an Alternative/Complement to Autogenous Bone for Grafting in Implant Dentistry. Journal Compilation Periodontology, 47, 172–192.

Hernigou, Poignard, A., Beaujean, & Rouard. (2005). Percutaneous autologous Bone marrow grafting for nonunions; influence of the number and concentration of progenitor cells. J Bone Joint Surg, 86, 1430–1437.

Hislop, W. S., Finlay, P. M., & Moos, K. P. (1993). A preliminary study into the use of anorganic bone in oral and maxillofacial surgery. Br. J. Oral Maxillofac. Surg, 31, 149–153.

Kamadjaja, D. B., Harijadi, A., Soesilowati, P., Eny, W., Nurul, M., Akhsanal, F., Fika, R. A., Roberto, S., Soesanto, Djodi, A., Andra, R., Peter, A., & Coen, P. (2017). Demineralized Freeze-Dried Bovine Cortical Bone: Its Potential for Guided Bone Regeneration Membran. International Journal of Dentistry, 1–9.

Knabe, C., Kraska, B., Koch, C., Gross, U., Zreiqat, H., & Stiller, M. (2005). A method for immunohistochemical detection of osteogenic markers in undecalcified bone sections. Biotechnic & Histochemistry, 81(1), 31–39.

Marx, R. (2007). Bone and Bone Grafting Healing. Oral Maxillofacial Surg Clin N Am, 19, 455–466.

Stephan, E. B., Jang, D., Lynch, S., Bush, P., & Dziak, R. (1999). Anorganic bovine bone supports osteoblastic cell attachment and proliferation. Journal Periodontal, 70, 364–369.

Wiss Ronal, A. (2011). Fracture master techniques in Orthopaedic surgery 3th edition. Lippicott William & Wilkins.

Difference Between Bone Healing Process with The Use Of Demineralized Freeze Dried Bone Xenograft and Bovine Bone Hydroxyapatite Xenograft Materials

Authors

Downloads

Login

Journal Policies

EditorialTeam

Meet Our Editorial Team

Instruction for Author

Tools

Visitors

IndexedBy

Indexed In

ISSN Barcode

Address

Contact Info: