ADIPOSE-DERIVED STEM CELL THERAPY ON NON-COMMUNICABLE DISEASE: A SYSTEMATIC REVIEW

stem cell adipose non-communicable disease treatment systematic review

Authors

  • Kevin Tandarto
    tandartok@gmail.com
    School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia
  • Reza Yuridian Purwoko Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency Republic of Indonesia, Indonesia
  • Caroline Oktarina Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia
  • Reganedgary Jonlean Faculty of Medicine, Universitas Indonesia, Jakarta. Indonesia
  • Cosphiadi Irawan Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia
  • Murdani Abdullah Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia -Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Jeanne Adiwinata Pawitan Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta
May 26, 2023

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The increasing number of non-communicable diseases demands practical therapy innovations, including adipose-derived stem cell application. This study aimed to analyze the effectiveness of adipose stem cell therapy on non-communicable disease patients. The method used in this study was a systematic review according to PRISMA 2020 guidelines. The database search was done on PubMed, Google Scholar, Proquest, and the EBSCO host database between 2016 and 2021. ROBINS-I tool and RoB-2 were used to assess the risk of bias in the clinical trial study. The first literature search identified a total of 2615 articles. After exclusion for some reason, 6 articles were included in this systematic review study. A total of five studies were included in this study. Based on the risk of bias assessment of the included studies, it was found that all studies had a low risk of bias in all domains. This study showed that the efficacy of adipose-derived stem cell therapy was inconsistent; however, the results were promising. In addition, the results showed that adipose-derived stem cell therapy was safe without significant side effects. Further study was needed to identify therapeutic strategies based on Evidence-based Medicine (EBM).