PROFILE OF NUTRITIONAL STATUS, HEMOGLOBIN, LEUKOCYTES, PLATELET, HEMATOCRIT, ALBUMIN AND SEROLOGY TEST IN CHILDREN INFECTED WITH DENGUE VIRUS AT DR SOETOMO HOSPITAL YEAR 2015
Downloads
The Dengue Virus Infection (DVI) triggers changes in the host's hematological, biochemical, and immunological aspects, affecting variables like hemoglobin (Hb), leukocytes (WBC), platelets (Plt), hematocrit (Hct), albumin (Alb), IgM, IgG, and NS1Ag Dengue. This study aims to investigate the demographic and clinical characteristics of DVI patients, considering factors such as gender, age, nutritional status, Hb, WBC, Plt, Hct, Alb, dengue serologic tests, and DVI stage. Using a cross-sectional descriptive approach, medical records of 74 subjects were analyzed. Subjects were categorized as DF (33.78%), DHF I (27.03%), DHF II (4.05%), DHF III (25.68%), and DHF IV (9.46%). Predominantly, subjects were aged 6-12 years (48.65%) and predominantly male (58.11%). Most patients had a normal nutritional status (50%), seen in both females and males (32.26%, 62.79%), with DF being dominant (14.86%, 28.92%). Over-nutrition occurred in DF, DHF without shock, and DHF with shock at rates of 12.5%, 33.33%, and 54.17%. DF prevailed in patients aged <6 years (17.57%), while DHF I, DHF II, DHF III were more common in those aged 6-12 years (14.86%, 2.70%, 16.22%), and DHF IV in those aged <6 years (8.11%). Key findings revealed increased Hb levels from DF to DHF, with 38 of 74 DVI patients exhibiting leukopenia. The DVI stage showed an inverse correlation with Plt levels. Hct levels rose in DHF patients, and they had relatively low Alb levels. Primary infections were more frequent in DF, while secondary infections were predominant in DHF with shock. The study also noted variations in over-nutrition prevalence across DVI stages among patients at Dr. Soetomo General Hospital Surabaya in 2015.
Buntubatu, S., Arguni, E., Indrawanti, R., Laksono, I. S., Prawirohartono, E. P. (2016), "Status Nutrisi sebagai Faktor Risiko Sindrom Syok Dengue”, Sari Pediatri, Vol. 18 No. 3, pp. 226-32.
Depkes. (2011), "Modul Pengendalian Demam Berdarah Dengue”.
Dharma, R., Hadinegoro, S. R. and Priatni, I. (2006), "Disfungsi Endotel pada Demam Berdarah Dengue”, Makara Kesehatan, Vol. 10 No. 1, pp. 17-23.
Hakim, L. and Kusnandar, A. J. (2012), "Hubungan Status Gizi dan Kelompok Umur dengan Status Infeksi Virus Dengue”, Aspirator, Vol. 4 No. 1, pp. 34-45.
Libraty, D. H., Wang, P., Guo, Z., Bigcas, V., Brion, J. D. and Capeding, R. Z. (2015), "The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever”, PloS Neglected Tropical Diseases, Vol. 9 No. 12, pp. 1-8.
Marón, G. M., Clará, A. W., Diddle, J. W., Pleités, E. B., Miller, L., Macdonald, G. and Adderson, E. E. (2010), "Association between nutritional status and severity of dengue infection in children in El Salvador”, The American Journal of Tropical Medicine and Hygiene, Vol. 82 No. 2, pp. 324-9.
Martí, A., Marcos, A. and Martinez, J. A. (2001), "Obesity and immune function relationships”, Obesity Reviews, Vol. 2 No. 2, pp. 131-40.
Mayetti. (2010), "Hubungan Gambaran Klinis dan Laboratorium sebagai Faktor Risiko Syok pada Demam Berdarah Dengue”, Sari Pediatri, Vol. 11 No. 5, pp. 367-73.
Megariani, Mariko, R., Alkamar, A. and Putra, A. E. (2014), "Uji Diagnostik Pemeriksaan Antigen Nonstruktural 1 untuk Deteksi Dini Infeksi Virus Dengue pada Anak”, Sari Pediatri, Vol. 16 No. 2, pp. 121-7.
Mercado, M., Acosta-Reyes, J., Parra, E., Pardo, L., Rico, A., Campo, A., Navarro, E. Viasus D. (2016), "Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015”, Eurosurveillance, Vol. 21 No. 22, pp. 1-6.
Patandianan, R. (2013), "Hubungan Kadar Hemoglobin dengan Jumlah Trombosit pada Pasien Demam Berdarah Dengue”, Jurnal e-Biomedik, Vol. 1 No. 2, pp. 868-72.
Raditha, C., Tumbelaka, A. R., Mangunatmadja, I., Tambunan, T., Advani, N. and Roeslani, R. (2013), "Profil Darah Tepi pada Anak dengan Infeksi Dengue”, Sari Pediatri, Vol. 15 No. 1, pp. 23-6.
Rajapakse, S. (2011), "Dengue Shock”, Journal of Emergencies, Trauma, and Shock, Vol. 4 No. 1, pp. 120-7.
Tedesco, J. M., Mehta, S., Beltrán-Ayala, E., Cárdenas, W. B., Endy, T. P., Ryan, S. J., Ibarra, A. M. S., Finkelstein, J. L. (2016), "Anthropometry and Dengue Fever in Coastal Ecuador”, The FASEB Journal, Vol. 30 No. S1.
Trang, N. T. H., Long N. P., Hue, T. T. M., Hung, L. P., Trung, T. D., Dinh, D. N., Luan, N. T., Huy, N. T. and Hirayama, K. (2016), "Association between nutritional status and dengue infection: a systematic review and meta-analysis”, BMC Infectious Disease, Vol. 16 No. 172, pp. 1-11.
WHO. (2009), "Dengue Guidelines for Diagnosis, Treatment, Prevention and Control”.
WHO. (2011), "Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever”.
Copyright (c) 2023 Zakirah Zuhra
This work is licensed under a Creative Commons Attribution 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without ristrictions.
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution (CC BY).
