UTILIZATION OF STEM CELL RESEARCH IN MICROGRAVITY FOR INNOVATION IN CELLULAR THERAPY ON EARTH
Downloads
Recent advancements in stem cell biology, coupled with developments in space exploration, have opened new avenues for regenerative medicine. Microgravity environments in space induce significant physiological changes in the human body, such as muscle atrophy, decreased bone density, and immune system impairments, mimicking accelerated aging and chronic disease progression. These conditions offer a unique opportunity to study stem cell behavior, proliferation, and differentiation, which occur at a faster pace in space compared to Earth. The three-dimensional (3D) microgravity environment provides a more accurate representation of the human body’s natural state than traditional two-dimensional culture systems, fostering enhanced stem cell development. Among the various stem cells studied in space, mesenchymal stem cells (MSCs) have shown promise for therapeutic applications, including the treatment of stroke, cancer, and neurodegenerative diseases. Research aboard the International Space Station (ISS) has demonstrated that MSCs maintain their properties, proliferate, and differentiate under microgravity conditions, offering potential for future therapies. Additionally, MSCs exhibit resistance to space radiation, protecting astronauts from its harmful effects by promoting tissue repair and releasing regenerative factors. This radiation resistance, coupled with cryopreservation techniques, enables MSCs to be used in long-duration space missions. The ongoing research on MSCs in space not only supports astronaut health but also holds the potential to revolutionize regenerative medicine on Earth. By understanding how microgravity influences stem cell behavior, scientists are uncovering critical insights into tissue repair and cell function, paving the way for innovative treatments for aging-related diseases and other medical conditions. These findings highlight the broader implications of space-based stem cell research for advancing human health both in space and on Earth.
Ankrum, J. A., Ong, J. F. and Karp, J. M. (2014), “Mesenchymal stem cells: immune evasive, not immune privileged”, Nature Biotechnology, Vol. 32 No. 3, pp. 252-60.
Baio, J., Martinez, A. F., Silva, I., Hoehn, C. V., Countryman, S., Bailey, L., Hasaniya, N., Pecaut, M. J. and Kearns-Joker, M. (2018), “Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties”, NPJ Microgravity, Vol. 4, pp. 13.
Blaber, E. A., Finkelstein, H., Dvorochkin, N., Sato, K. Y., Yousuf, R., Burns, B. P., Globus, R. K. and Almeida, E. A. C. (2015), “Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells”, Stem Cells and Development, Vol. 24 No. 22, pp. 2605-21.
Caplan, H., Olson, S. D., Kumar, A., George, M., Prabhakara, K. S., Wenzel, P., Bedi, S., Toledano-Furman, N. E., Triolo, F., Kamhieh-Milz, J., Moll, G. and Jr, C. S. C. (2019), “Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application”, Frontiers in Immunology, Vol. 10.
Chen, C. M., Hu, Z. G., Liu, S. B. and Tseng, H. (2012), “Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace”, Expert Opinion on Biological Therapy, Vol. 12 No. 5, pp. 593-608.
Chinnadurai, R., Bates, P. D., Kunugi, K. A., Nickel, K. P., DeWerd, L. A., Capitini, C. M., Galipeau, J. and Kimple, R. J. (2021), “Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease”, Frontiers in Immunology, Vol. 12.
Chinnadurai, R., Forsberg, M. H., Kink, J. A., Hematti, P. and Capitini, C. M. (2020), “Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome”, Current Stem Cell Reports, Vol. 6 No. 3, pp. 77-85.
Doorn, J., Moll, G., Blanc, K. L., van Blitterswijk, C. and de Boer, J. (2012), “Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements”, Tissue Engineering, Vol. 18 No. 2, pp. 101-15.
Ghani, F. and Zubair, A. C. (2024), “Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth”, NP Microgravity, Vol. 10 No. 1, pp. 88.
Giri, J. and Galipeau, J. (2020), “Mesenchymal stromal cell therapeutic potency is dependent upon viability, route of delivery, and immune match”, Blood Advances, Vol. 4 No. 9, pp. 1987—97.
Giri, J. and Moll, G. (2022), “MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel”, Current Stem Cell Reports, Vol. 8, pp. 1-13.
Huang, P., Russell, A. L., Lefavor, R., Durand, N. C., James, E., Harvey, L., Zhang, C., Countryman, S., Stodieck, L. and Zubair, A. C. (2020), “Feasibility, potency, and safety of growing human mesenchymal stem cells in space for clinical application”, NPJ Microgravity, Vol. 6.
Imura, T., Otsuka, T., Kawahara Y. and Yuge, L. (2019), ““Microgravity” as a unique and useful stem cell culture environment for cell-based therapy”, Regenerative Therapy, Vol. 12, pp. 2-5.
Jha, R., Wu, Q., Singh, M., Preininger, M. K., Han, P., Ding, G., Cho, H. C., Jo, H., Maher, K. O., Wagner, M. B. and Xu, C. (2016), “Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells”, Scientific Reports, Vol. 6.
Li, J., Kwong, D. L. W. and Chan, G. C. (2007), “The effects of various irradiation doses on the growth and differentiation of marrow-derived human mesenchymal stromal cells”, Pediatric Transplantation, Vol. 11 No. 4, pp. 379-87.
Ma, C., Duan, X. and Lei, X. (2023), “3D cell culture model: From ground experiment to microgravity study”, Frontiers in Bioengineering and Biotechnology, Vol. 11.
Moll, G., Ankrum, J. A., Kamhieh-Milz, J., Bieback, K., Ringdén, O., Volk, H., Geissler, S. and Reinke, P. (2019), “Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines”, Trends in Molecular Medicine, Vol. 25 No. 2, pp. 149-163.
Moll, G., Ankrum, J. A., Olson, S. D. and Nolta, J. A. (2022), “Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products”, Stem Cells Translational Medicine, Vol. 11 No. 1, pp. 2-13.
Moll, G., Drzeniek, N., Kamhieh-Milz, J., Geissler, S., Volk, H. and Reinke, P. (2020), “MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy”, Frontiers in Immunology, Vol. 11, pp. 1091.
Moll, G., Geißler, S., Catar, R., Ignatowicz, L., Hoogduijn, M. J., Strunk, D., Bieback, K. and Ringdén, O. (2016), “Cryopreserved or Fresh Mesenchymal Stromal Cells: Only a Matter of Taste or Key to Unleash the Full Clinical Potential of MSC Therapy?”, Advances in Experimental Medicine and Biology, Vol. 951, pp. 77-98.
Nicolay, N. H., Perez, R. L., Saffrich, R. and Huber, P. E. (2015), “Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic”, Oncotarget, Vol. 6 No. 23, pp. 19366-80.
Nicolay, N. H., Sommer, E., Lopez, R., Wirkner, U., Trinh, T., Sisombath, S., Debus, J., Ho, A. D., Saffrich, R. and Huber, P. E. (2013), “Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation”, International Journal of Radiation, Oncoly, Biology, Physics, Vol. 87 No. 5, pp. 1171-8.
Park, Y., Huh, K. M. and Kang, S. (2021), “Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research”, International Journal of Molecular Sciences, Vol. 22 No. 5, pp. 2491.
Rampoldi, A., Forghani, P., Li, D., Hwang, H., Armand, L. C., Fite, J., Boland, G., Maxwell, J., Maher, K. and Xu, C. (2022), “Space microgravity improves proliferation of human iPSC-derived cardiomyocytes”, Stem Cell Reports, Vol. 17 No. 10, pp. 2272-2285.
Sugrue, T., Lowndes, N. F. and Ceredig, R. (2014), “Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells”, Stem Cells, Vol. 32 No. 8, pp. 2188-200.
Wang, K., Cui, W., Yang, X., Tao, A., Lan, T., Li, T., and Luo, L. (2021), “Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects”, Cells, Vol. 10 No. 2, pp. 294.
Yuge, L., Kajiume, T., Tahara, H., Kawahara, Y., Umeda, C., Yoshimoto, R., Wu, S., Yamaoka, K., Asashima, M., Kataoka, K. and Ide, T. (2006), “Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation”, Stem Cells and Development, Vol. 15 No. 6, pp. 921-9.
Zubair, A. (2020), “Studying stem cells in space for the benefit of humankind on Earth and beyond”.
Copyright (c) 2024 Journal of Stem Cell Research and Tissue Engineering
This work is licensed under a Creative Commons Attribution 4.0 International License.
1. As an author you (or your employer or institution) may do the following:
- make copies (print or electronic) of the article for your own personal use, including for your own classroom teaching use;
- make copies and distribute such copies (including through e-mail) of the article to research colleagues, for the personal use by such colleagues (but not commercially or systematically, e.g. via an e-mail list or list server);
- present the article at a meeting or conference and to distribute copies of the article to the delegates attending such meeting;
- for your employer, if the article is a ‘work for hire', made within the scope of your employment, your employer may use all or part of the information in the article for other intra-company use (e.g. training);
- retain patent and trademark rights and rights to any process, procedure, or article of manufacture described in the article;
- include the article in full or in part in a thesis or dissertation (provided that this is not to be published commercially);
- use the article or any part thereof in a printed compilation of your works, such as collected writings or lecture notes (subsequent to publication of the article in the journal); and prepare other derivative works, to extend the article into book-length form, or to otherwise re-use portions or excerpts in other works, with full acknowledgement of its original publication in the journal;
- may reproduce or authorize others to reproduce the article, material extracted from the article, or derivative works for the author's personal use or for company use, provided that the source and the copyright notice are indicated, the copies are not used in any way that implies JSCRTE endorsement of a product or service of any employer, and the copies themselves are not offered for sale.
All copies, print or electronic, or other use of the paper or article must include the appropriate bibliographic citation for the article's publication in the journal.
2. Requests from third parties
Although authors are permitted to re-use all or portions of the article in other works, this does not include granting third-party requests for reprinting, republishing, or other types of re-use. Requests for all uses not included above, including the authorization of third parties to reproduce or otherwise use all or part of the article (including figures and tables), should be referred to JSCRTE by going to our website at http://e-journal.unair.ac.id/index.php/JSCRTE
3. Author Online Use
- Personal Servers. Authors and/or their employers shall have the right to post the accepted version of articles pre-print version of the article, or revised personal version of the final text of the article (to reflect changes made in the peer review and editing process) on their own personal servers or the servers of their institutions or employers without permission from JSCRTE, provided that the posted version includes a prominently displayed JSCRTE copyright notice and, when published, a full citation to the original publication, including a link to the article abstract in the journal homepage. Authors shall not post the final, published versions of their papers;
- Classroom or Internal Training Use. An author is expressly permitted to post any portion of the accepted version of his/her own articles on the author's personal web site or the servers of the author's institution or company in connection with the author's teaching, training, or work responsibilities, provided that the appropriate copyright, credit, and reuse notices appear prominently with the posted material. Examples of permitted uses are lecture materials, course packs, e-reserves, conference presentations, or in-house training courses;
- Electronic Preprints. Before submitting an article to an JSCRTE, authors frequently post their manuscripts to their own web site, their employer's site, or to another server that invites constructive comment from colleagues. Upon submission of an article to JSCRTE, an author is required to transfer copyright in the article to JSCRTE, and the author must update any previously posted version of the article with a prominently displayed JSCRTE copyright notice. Upon publication of an article by the JSCRTE, the author must replace any previously posted electronic versions of the article with either (1) the full citation to the work with a Digital Object Identifier (DOI) or link to the article abstract in JSCRTE homepage, or (2) the accepted version only (not the final, published version), including the JSCRTE copyright notice and full citation, with a link to the final, published article in journal homepage.
4. Articles in Press (AiP) service
JSCRTE may choose to publish an abstract or portions of the paper before we publish it in the journal. Please contact our Production department immediately if you do not want us to make any such prior publication for any reason, including disclosure of a patentable invention.
5. Author/Employer Rights
If you are employed and prepared the article on a subject within the scope of your employment, the copyright in the article belongs to your employer as a work-for-hire. In that case, JSCRTE assumes that when you sign this Form, you are authorized to do so by your employer and that your employer has consented to the transfer of copyright, to the representation and warranty of publication rights, and to all other terms and conditions of this Form. If such authorization and consent has not been given to you, an authorized representative of your employer should sign this Form as the Author.
6. JSCRTE Copyright Ownership
It is the formal policy of JSCRTE to own the copyrights to all copyrightable material in its technical publications and to the individual contributions contained therein, in order to protect the interests of the JSCRTE, its authors and their employers, and, at the same time, to facilitate the appropriate re-use of this material by others. JSCRTE distributes its technical publications throughout the world and does so by various means such as hard copy, microfiche, microfilm, and electronic media. It also abstracts and may translate its publications, and articles contained therein, for inclusion in various compendiums, collective works, databases and similar publications
Every accepted manuscript should be accompanied by "Copyright Transfer Agreement" prior to the article publication.
