STRUKTUR DAN PERAN SITOSKELETON PADA ERITROSIT
Downloads
The cytoskeleton is a structural molecule that plays a role in the maintenance of cell shape and preserve cell structure that allowing the movement of organelles, chromosomes, cilia, and the movement of the cell itself. Cytoskeleton in erythrocyte becomes interesting to discuss because it plays an important role in maintaining cell shape and flexibility of great strength in resisting friction with the walls of capillaries that has smaller diameter than erythrocytes. The aim was to discuss structure and function of cytoskeleton, especially in erythrocyte membrane. The cytoskeleton of erythrocyte membrane is mainly composed by spectrin, a long chain-shaped protein, thin, and flexible. Spectrin is supported by a wide range of peripheral and integral proteins, such as ankyrin, actin, a protein band 4.1, and 4.2, the protein band 3 (anion transporter proteins), as well as glycophorin A, B, C, to form a framework in order to support the shape and flexibility of erythrocytes. Abnormalities of spectrin can cause hereditary spherocytosis and hereditary elliptocytosis, which has manifestations as hemolytic anemia.
Alberts, B. et al., 2008. Molecular Biology of The Cell. Fifth edition. Abingdon: Garland Science, hal.629-650.
An, X. et al., 2002. Shear-Response of the Spectrin Dimer-Tetramer Equilibrium in the Red Blood Cell Membrane. The Journal of Biological Chemistry, 277(35), hal.31796-31800.
Gartner, L.P. & Hiatt, J.L., 2007. Color Textbook of Histology. Third edition. Philadelphia: Saunders Elsevier, hal.42-48 & 219-224.
Goodman, S.R., 2008. Medical Cell Biology. Third edition. California: Academic Press, hal.82-88.
Gov, N.S. & Safran, S.A., 2005. Red Blood Cell Membrane Fluctuations and Shape Controlled by ATP-Induced Cytoskeletal Defects. Biophysical Journal, 88, hal.1859–1874.
Janmey, P., 1995. Cell Membranes and the Cytoskeleton. Elsevier Handbook of Biological Physics, 1, hal.807-816.
Kabaso, D. et al., 2010. Curling and Local Shape Changes of Red Blood Cell Membranes Driven by Cytoskeletal Reorganization. Biophysical Journal, 99, hal.808-816.
Kabaso, D. et al., 2011. Cytoskeletal Reorganization of Red Blood Cell Shape: Curling of Free Edges and Malaria Merozoites. Advance in Planar Lipid Bilayer and Liposomes, 13, hal.74-100.
Murray, R.K., 2009a. Muscle and the Cytoskeleton. In: Murray, R.K., Bender, D.A., Botham, K.M., Kennelly, P.J., Rodwell, V.W., Weil, P.A.,eds. 2009. Harper's Illustrated Biochemistry. 28thedition. New York: The McGraw-Hill Companies, hal.562-565.
Murray, R.K., 2009b. Red and White Blood Cells. In: Murray, R.K., Bender, D.A., Botham, K.M., Kennelly, P.J., Rodwell, V.W., Weil, P.A.,eds. 2009. Harper's Illustrated Biochemistry. 28thedition. New York: The McGraw-Hill Companies, hal.593-602.
Nassar, S. et al., 1998. Molecular Defects of Red Blood Cell Membrane Proteins Among Egyptian Children with Hereditary Spherocytosis. Laboratory Hematology, 4, hal.269-275.
Zhang, R. & Brown, F.L.H., 2008. Cytoskeleton Mediated Effective Elastic Properties of Model Red Blood Cell Membranes. arXiv, 1, hal.1-38.
Copyright (c) 2019 Majalah Biomorfologi
This work is licensed under a Creative Commons Attribution 4.0 International License.
1. The journal allows the author(s) to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions.
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution 4.0 International License (CC-BY).
