Gut-Brain Axis, Notch, and Brain Cancer: ‘The Rising Three’
Introduction:The gut-brain axis (GBA) enables reciprocal communication between the central nervous system and the enteric nervous system. A connection between the gut-brain axis, NOTCH, and brain cancer is an intricate subject that is worthy of learning more about. Brain cancer has a complex pathophysiology and structure in this context, thus getting from diagnosis to treatment is still difficult. The involvement of NOTCH in the signalling pathway may be relevant to both brain cancer and the gut-brain axis. Methods: This study is a systematic review conducted by using numerous search engines, including PubMed, ProQuest, and the Cambridge Core from July until August 2023. The collected materials were then filtered and investigated further. Result: The existence of the gut brain axis is a highly intriguing topic to explore extensively. The intricacy of NOTCH and the gut-brain axis may show a link behind brain cancer pathogenesis. The literature review conducted yielded a total of two publications, which were subsequently subjected to a more comprehensive analysis. Discussion: The gut-brain axis (GBA) refers to a bidirectional communication network that exists between the central nervous system and the enteric nervous system, which is responsible for regulating the functions of the gastrointestinal tract. The identification of the NOTCH signalling pathway is an indicative of its involvement in the development of brain tumours. Conclusion: All three of the excellent points on the gut-brain axis, NOTCH, and brain cancer are all linked. NOTCH's position as a signalling channel is linked to brain cancer, as is the gut-brain axis, which is also linked to brain cancer. Furthermore, this role relationship has the potential to generate something novel in terms of diagnosis and therapy, which can then be researched further.
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