Original Research

Nutritional status, hemoglobin, and albumin levels in predicting platinum resistance in ovarian cancer at Dr. Saiful Anwar Hospital, Malang, Indonesia

Tatit Nurseta, Ayu Rizky Widowati
Department of Obstetrics and Gynaecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia

HIGHLIGHTS

1. Nutrition status, hemoglobin, and albumin levels are not predictors for platinum resistance.
2. Hemoglobin and albumin levels increased in both platinum-sensitive or platinum-resistant.

ABSTRACT

Objectives: To assess whether nutritional status, hemoglobin and albumin can be used as predictors of platinum resistance in ovarian cancer patients.
Materials and Methods: This cross-sectional study involved 80 patients who have been diagnosed with ovarian cancer who have undergone 6 series of platinum-based chemotherapy. Subsequently, these patients were categorized into two groups, platinum-resistant and platinum-sensitive, depending on their recurrence status after completing the chemotherapy regimen. A comparative analysis was conducted between the two groups, focusing on their nutritional status determined by body mass index (BMI), as well as hemoglobin and albumin levels.
Results: There was no significant difference in BMI score between platinum-sensitive and platinum-resistant (p=0.743). Hemoglobin levels also showed no significant difference in both groups, whether before chemotherapy (p=0.072) or after chemotherapy (p=0.055). However, there was significant increase in platinum-sensitive (p=0.002) and platinum-resistant (p=0.025). Pre-chemotherapy albumin levels showed no significant difference between the two groups (p=0.218), but a significant difference emerged post-chemotherapy (p=0.027). There was a significant increase from pre-chemotherapy to post-chemotherapy levels in both platinum-sensitive and platinum-resistant (p=0.000).
Conclusion: Nutritional status, hemoglobin, and albumin levels do not affect the incidence of platinum resistance.

Keywords: platinum resistance; ovarian cancer; nutritional status; hemoglobin; albumin; human and health