The evidence for the influence of musical compositions during pregnancy to the structure and functions of the offsprings' brain
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Objective: to compile studies in Surabaya on the effect of Mozart compositions during pregnancy on the number of the offsprings brain neuron, glia, BDNF, apoptotic neurons and, neuronal dendritic density. These series of studies aimed to develop environmental-enrichment model during pregnancy so we can have better brain for the next generation. Better brain means better capacity in processing information, solving the problems, and creating new solutions that depends on the number of neuron, glia, ratio glia/ neuron and synapses. We do believe in the motto of "From Neurons to Nation”
Overview: There were 38 studies, in animal models except two in human subjects, all of them with control, prospective, and randomized. The first group consist of analyze the frequency, sequence, time, duration, gestational age, distant, and intensity of Mozart composition. The second group: try to analyze the mechanism and compare with variety of other compositions including other western music(Chopin, Beethoven, Blues, Jazz, Rock) and Indonesian music(Gamelan Jawa, Sunda, Bali, Pop, Religious). The third group: combine with nutrition, reverse sequence, involving cerebrum and cerebellum, and right-left hemisphere. There were no growth restricted, dead, and malformed offsprings in both groups. The BDNF expression, synapsin I expression, the number of neuron, number of glia, and dendritic density of the exposed groups were higher than control. The neuronal apoptotic index were lower in the exposed groups
Conclusions: Mozart compositions during pregnancy increased the BDNF, synapsin I, number of neuron, number of glia, dendritic density and, also decreased the neuronal apoptosis in offsprings' brainHermanto TJ. Prostration Inside the Womb: Headstart in the Womb through Combination of 11-14 Mozart Compilations and Nutrition. 2012. Surabaya: Global Persada Press - in Bahasa Indonesia
Toni W, Hermanto TJ. Comparison of The Newborn Umbilical Brain-Derived Neurotrophic Factor Exposed and Nonexposed to Sequence of Mozart Compositions During Pregnancy. MOG 2013;21:109-114
Rozi A A, Widjiati, Hermanto TJ. The Influence of Sequence of Mozart Compositions during Pregnancy to the Expression of Brain-Derived Neurotrophic Factor, Number of Neuron and Glia cells at Cerebrum and Cerebellum Rattus norvegicus Offsprings. 2015. unpublished
Nareswari I.C.M, Budi W, Widjiati, Hermanto TJ. The Influence of Sequence of Mozart Compositions during Pregnancy to the Expression of Brain-Derived Neurotrophic Factor, MTORC1 and Dendritic Density at Cerebrum and Cerebellum Rattus norvegicus Offsprings. 2015. unpublished
Harya N, Widjiati, Hermanto TJ. The Influence of Sequence of Mozart Compositions during Pregnancy to the Expression of Brain-Derived Neurotrophic Factor and Protein kinase at Cerebrum and Cerebellum Rattus norvegicus Offsprings. 2015. unpublished
Permatasari, P., Hermanto, T.J., Widjiati. The Difference Influence Between Mozart, Beethoven, and Chopin Compositions Exposure During Pregnancy to the Cerebrum and Cerebellum Brain-Derived Neurotrophic Factor Expression of Rattus norvegicus Offspring'. 2018. Thesis - under prep for publishing in Sinta
Amishinta, A. A., Hermanto, T.J., Widjiati. The Difference Impact of Mozart, Beethoven, and Chopin Compositions During Pregnancy to Dendritic Density of Cerebrum and Cerebellum of Rattus norvegicus Newborn. 2018. Thesis - under prep for publishing in Sinta
Fajrin, H.D., Hermanto, T.J., Widjiati. Beethoven and Chopin Compositions Exposure During Pregnancy Gave Higher Cerebrum and Cerebellum Neuronal Apoptosis of Rattus norvegicus Offspring Compared with Mozart Compositions. 2018. Thesis under prep for publishing in Sinta
Ningsih, A.H., Hermanto, T.J., Widjiati. Mozart Composition During Pregnancy Gave Higher Number of Neuronal Cells in Cerebrum and Cerebellum of Newborn Rattus norvegicus Compared with Beethoven and Chopin Compositions. 2019. Thesis - under prep for publishing in Sinta
Syania MO, Hermanto TJ, Mudjiani B. Mozart Compositions During Pregnancy Gave Higher Number of Cerebral and Cerebellar Offsprings Neurons Compared to Jazz, Blues, and Rock Compositions. Global Journal of Medical Research: Gynecology and Obstetrics. 2019.vol 19 issue 4
Setiawati N.S., Hermanto T.J., Widjiati. Mozart Compositions During Pregnancy Gave Higher Number of Cerebral and Cerebellar Offsprings Glia Cells Compared to Jazz, Blues, and Rock Compositions. 2019, under prep for publishing in Sinta
Putri, K.E., Hermanto, T.J., Widjiati. The Difference in the Number of Neuron In Cerebrum and Cerebellum Of Rattus Norvegicus Offsprings Which Exposed to Mozart, Javanese, Sundanese and Balinese Gamelan Music During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Ardiyani, F., Hermanto, T.J., Widjiati. The Different Influence of Mozart, Jawa, Sunda, and Bali Gamelan Compositions during Pregnancy to the Neuronal Apoptotic Index of Cerebrum and, Cerebellum the Offsprings' Rattus norvegicus. 2019. Thesis under prep for publishing in Sinta
Ramadhani, N., Hermanto, T.J., Widjiati. The Difference of Expression of Synapsin 1 In Cerebrum And Cerebellum Rattus norvegicus Offspring Between Exposed to Music Mozart with Traditional Gamelan Java, Sunda, and Bali During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Widoyanti, V., Hermanto, T.J., Widjiati. The Difference in Offsprings Rattus norvegicus Brain-Derived Neurotrophic Factor Cerebrum, and Cerebellum Expression Among Those Which Exposed to Mozart Music, Javanese, Sundanese, and Balinese Gamelan During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Khasanah, N.R., Hermanto, T.J., Widjiati. Differences in the Number of Glia in Cerebrum And Cerebellum Rattus norvegicus Between Mozart Music with Java, Sunda, and Traditional Gamelan Bali During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Muminah, U., Hermanto, T.J, Widjiati. The Difference Of Synapsin Expression In The Cerebrum And Cerebellum of the Rattus norvegicus Offsprings Exposed to Mozart, Pop, and Religious Music Compilations During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Estuning, P., Hermanto, T.J., Widjiati. Mozart, Pop, Religi Music Compilations During Pregnancy Cause Differences in the Number of Glial (Astrocytes, Oligodendrocytes, Microglia) Cerebrum and Cerebellum of Offsprings Rattus norvegicus. 2019. Thesis under prep for publishing in Sinta
Sholichah, A., Hermanto, T.J., Widjiati. Comparison of the Effect Of Mozart, Pop, and Religious Music Compilations During Pregnancy to the Number of Neurons in Cerebrum and Cerebellum Rattus norvegicus Offsprings. 2019. Thesis under prep for publishing in Sinta
Sukmawati, D., Hermanto, T.J., Widjiati. Differences in Rattus norvegicus Offsprings' Cerebrum And Cerebellum Neuronal Apoptotic Index Exposed to Mozart, Pop, and Religious Music Compilations During Pregnancy. 2019. Thesis under prep for publishing in Sinta
Habibie PH, Hermanto TJ, Widjiati. Comparison of Neuronal Cell Apoptotic Indices in the Cerebrum and Cerebellum of Newborn Rattus norvegicus Exposed to Mozart's Music In Default Sequence, Reversed Sequence, and Without Exposure In Utero. 2017. Thesis, unpublished.
Nova L, Hermanto TJ, Widjiati. The Sequence of Mozart Compositions in Utero Cause Difference in the Number of Neurons and Glia in Rattus norvegicus Offsprings's Cerebrum and Cerebellum. 2017. Thesis, unpublished
Panjaitan HMB, Hermanto TJ, Widjiati. Default Sequence Of Mozart's Compositions During Pregnancy Gave Higher Dendritic Density in the Cerebrum and Cerebellum of Rattus norvegicus Offsprings Compared With Reversed Sequence and Control. Majalah Obstetri Ginekologi. 2017. Vol 27, No 1 (2019). http://dx.doi.org/10.20473/ mog.V1I12019.5-11
Hidayati A, Hermanto TJ, Widjiati. Increased Brain-Derived Neurotrophic Factor in the Cerebrum and Cerebellum of Rattus norvegicus Newborn with Exposure To Mozart's Music in Default Sequence Compared with the Reversed Sequence and Without Exposure During Gestation. Published in Majalah Obstetri Ginekologi. 2017. Vol 26, No 2 (2018). http://dx.doi.org/10.20473/ mog.V26I22018.67-73
Khotimah FK, Hermanto TJ, Widjiati. The Increase of Dendritic Density in the Cerebrum and Cerebellum of Newborn Rattus norvegicus Due to Mozart Stimulation during Pregnancy with 50% Food Restriction. 2017. Thesis, unpublished
Permatasari YP, Hermanto TJ, Widjiati. Effect of Prenatal Mozart Composition on Brain-Derived Neurotrophic Factor Expression in Cerebrum and Cerebellum of Rattus norvegicus Offspring from Food Restriction 50 Model. MOG. 2017.Vol 26, No 1 (2018). http://dx.doi.org/10.20473/mog.V26I1 2018.1-6
Sjahruddin DD, Hermanto TJ, Widjiati. The Effect of Prenatal Mozart Music Exposure to the Number of Neuron and Glia Cells (Astrocyte, Oligodendrocyte, Microglia) in the Cerebrum and Cerebellum Of Newborn Rattus norvegicus from the Parent Food Restriction 50% Model Rattus norvegicus. 2017. Thesis, unpublished
Alfianto R, Hermanto TJ, Widjiati. Apoptosis in the 50% Food Restriction Model Rattus norvegicus Cerebrum and Cerebellum Neuron Cells Which Exposed to Mozart Music During Gestation. 2017. Thesis, unpublished
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