A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia
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HIGHLIGHTS
- This study aimed to identify the characteristics of Gestational Trophoblastic Neoplasia (GTN).
- GTN is chemosensitive, but without appropriate therapy and follow-up, GTN will develop into complications and fatalities.
ABSTRACT
Objective: Gestational Trophoblastic Neoplasia (GTN) is a pregnancy-related malignancy due to abnormal proliferation of trophoblastic tissue. This study aimed to identify the characteristics of patients with GTN to help diagnose cases of GTN earlier and provide better treatment.
Materials and Methods: This was a descriptive retrospective study on medical records of patients with GTN in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, during the period of January 2018 to December 2020 with a total sampling technique. There were 41 patients with GTN included as study subjects.
Results: Forty-one cases of GTN met the inclusion criteria out of the fifty medical records collected. The majority of patients aged 21 – 30 years old (34%) and had parity status without data (42%). Regarding the clinical profile based on prognostic factors, the predominant patients (71%) also had no data about the time interval between the end of the last pregnancy and the first time diagnosed by GTN, Those with more than 100,000 mIU/ml of beta-hCG levels were 32%, and those without metastases were 41.5%. Most patients belonged to the low-risk group (49%) and received chemotherapy (71%) with the MTX LD regimen (69%).
Conclusion: GTN occurred predominantly in reproductive women that belonged to the low-risk group. Furthermore, chemotherapy is one of the chosen therapy for those patients.
Kaur B. Pathology of gestational trophoblastic disease (GTD). Best Pract Res Clin Obstet Gynaecol. 2021;74:3-28. doi: 10.1016/j.bpobgyn. 2021.02.005. Epub 2021 Mar 31. PMID: 34219021.
Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531-9. doi: 10.1016/j.ajog. 2010.06.073. Epub 2010 Aug 21. PMID: 20728069.
Biscaro A, Braga A, Berkowitz RS. Diagnosis, classification and treatment of gestational trophoblastic neoplasia. Rev Bras Ginecol Obstet. 2015;37(1):42-51. doi: 10.1590/SO100-720320140 005198. PMID: 25607129.
Goldstein DP, Berkowitz RS. Current management of gestational trophoblastic neoplasia. Hematol Oncol Clin North Am. 2012;26(1):111-31. doi: 10.1016/j.hoc.2011.10.007. Epub 2011 Nov 21. PMID: 22244665.
Li J, Yang J, Liu P, et al. Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study. BMC Cancer. 2016;16:347. doi: 10.1186/s12885-016-2383-1. PMID: 27251425; PMCID: PMC4890243.
Raudina F, Hidayat YM, Rachmayati S. Response to chemotherapy in patients with gestational trophoblastic neoplasia in Dr. Hasan Sadikin General Hospital. 2020;7(3):128–35. doi: 10.15850/ amj.v7n3.1894.
Katke RD. Gestational trophoblastic disease and its complications: Review of patient profiles and management at a tertiary care centre: Southeast Asian J Case Rep Rev. 2016;5(4):2446–58.
Jagtap SV, Aher V, Gadhiya S, et al. Gestational trophoblastic disease - Clinicopathological study at tertiary care hospital. J Clin Diagn Res. 2017;11(8):EC27-EC30. doi: 10.7860/JCDR/2017/ 27232.10458. Epub 2017 Aug 1. PMID: 28969138; PMCID: PMC5620778.
Azizi AR, Mahendra INB, Widiyanti ES. Profil pasien penyakit trofoblastik gestasional di RSUP Sanglah Denpasar periode 1 Januari 2017 sampai 31 Desember 2017 [Profile of gestational trophoblastic disease patients in Sanglah Hospital, Denpasar]. J Med Udayana. 2019;8(7).
Hurteau JA. Gestational trophoblastic disease: management of hydatidiform mole. Clin Obstet Gynecol. 2003;46(3):557-69. doi: 10.1097/0000 3081-200309000-00007. PMID: 12972737.
Bhattacharya A, Panja TK, Bhattacharya A, et al. A prospective study of gestational trophoblastic disease profile with special reference to mortality and pregnancy outcome after successful management of the same. Int J Community Med Public Heal. 2019;6(10):4363. doi: 10.18203/2394-6040.ijcmph20194495.
Orr JW Jr, Austin JM, Hatch KD, et al. Acute pulmonary edema associated with molar pregnancies: a high-risk factor for development of persistent trophoblastic disease. Am J Obstet Gynecol. 1980;136(3):412-5. doi: 10.1016/0002-9378(80)90875-3. PMID: 6243445.
Ha MC, Cordier S, Bard D, et al. Agent orange and the risk of gestational trophoblastic disease in Vietnam. Arch Environ Health. 1996;51(5):368-74. doi: 10.1080/00039896.1996.9934424. PMID: 8896 386.
Banerjee D, Barsode SD, Basu P. Management of Gestational Trophoblastic Diseases-An Update. Rev Recent Clin Trials. 2015;10(4):255-62. doi: 10.2174/1574887110666150923111731. PMID: 26411957.
Angelina YA, Hartono P. Characteristics of gesta-tional thropoblast tumor in Dr. Soetomo Hospital, year 2015-2017. Maj Obstet Ginekol. 2019;27(2):79-83. doi: 10.20473/mog.V27I22019. 79-83.
Hemida R, Sauthier P, Toson E, et al. Prognosis of gestational trophoblastic neoplasia in women at 40 years old and above: A multicentre retrospective study. Clin Oncol Res. 2020;1–6. doi: 10.31487/ j.COR.2020.09.10.
Hemida RAE, Toson E, Shalaby H, et al. Chemo-resistant gestational trophoblastic neoplasia, 5-years experience of Mansoura University Hospital, Egypt. Open J Obstet Gynecol. 2011;1(3):153–7. doi: 10.4236/ojog.2011.13029.
Sinaga RJ, Tobing MDL, Harsono AB. Karakteristik pasien tumor trofoblas gestasional risiko rendah dengan karakteristik pasien tumor trofoblas gestasional risiko rendah dengan kemoresitensi terhadap metotreksat yang dirawat di RSUP Dr. Hasan Sadikin Bandung periode 2011 – 2015. Obgynia. 2018;1(2):147-54. doi: 10.24198/ obgynia.v1n2.47.
Sita-Lumsden A, Short D, Lindsay I, et al. Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000-2009. Br J Cancer. 2012;107(11):1810-4. doi: 10.1038/bjc.2012.462. Epub 2012 Oct 11. PMID: 23059744; PMCID: PMC3504950.
Hussain A, Shiekh AA, Bhat GM, et al. Gestational trophoblastic neoplasia, management as per risk stratification in a developing country. Indian J Med Paediatr Oncol. 2016;37(1):28-31. doi: 10.4103/ 0971-5851.177012. PMID: 27051154; PMCID: PMC4795371.
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