Genotype of human papilloma virus in invasive cervical carcinoma at Dr. Soetomo Hospital Surabaya
Downloads
Objectives: To identify the variants of genotype HPV that most often found in ICC at Dr Soetomo Hospital Surabaya.
Materials and Methods: This was an explorative study with cross sectional approach. Specimens used were 30 formalin fix parrafin embedded from squamous cell carcinoma (SCC), adenocarcinoma (AD) dan adenosquamous carcinoma (AS) cervival cancer parients at Dr Soetomo Hospital Surabaya around Januari-Desember 2013, then used for DNA virus extraction and continued for PCR and HPV genotyping.
Result : The result of HPV genotyping showed 10 positives from SCC, 6 positives and 4 negatives from AD, and 9 positives and 1 negative from AS. HPV infections in SCC were single infection by HPV 16, 18, 45, 56, and multiple infection by HPV 16+45, in AD were single infection by HPV 16,18, anad multiple infection by HPVhr+hr 68b+72 and HPVlr+hr 6+18+45, and in AS were single infection by HPVhr 16, 18, 45 and mutiple infection by HPV lr+hr 6+59.
Conclusion : Infections HPV in ICC were single infection by HPV16, 18, 45, 56 and mutiple infection by HPV16+45, 68b+72, 6+18+45, 6+59. HPV 18 has highest prevalence in ICC patient from Dr Soetomo Hospital, followed by HPV16, 6, 45, 56, 59.Vet JNI, de Boer BEWM, Siregar B, Lisnawati, BS, et al. Prevalence of human papillomavirus in Indo-nesia: a population-based study in three re-gions. British Journal of Cancer. 2008;99:214–8.
Schellekens MC, Dijkman A, Aziz MF, et al. Pre-valence of single and multiple HPV types in cervical carcinomas in Jakarta, Indonesia. Gyneco-logic Oncology. 2004;93:49–53.
Sahiratmadja E, Tobing MDL, Dewayani BM, et al. Multiple human papilloma virus infections predo-minant in squamous cell cervical carcinoma in Bandung. Universa Medicina, 2014;33:58–64.
Tobing MDL, Edhyana S, Dinda M et al. Human papillomavirus genotypes profile in cervical cancer patients at dr. Hasan Sadikin general hospital, Bandung, Indonesia. Asian Pacific Journal of Can-cer Prevention. 2014;15(14):5781–85.
Stanley M, Pinto LA, Trimble C. Human papil-lomavirus vaccines - immune responses. Vaccine. 2012;30(SUPPL.5):F83–F87.
Stanley M. Immune responses to human papilloma-virus. Vaccine. 2006;1:16–22.
Hausen H. Papillomaviruses and cancer : from basic studies to clinical application. Nature Re-views Cancer. 2002;2:342–50.
IARC Press. WHO classification of tumours of the female reproductive organs. 2014. p. 207–52.
Kementerian Kesehatan RI, Pusat Data dan Informasi Kesehatan. Data dan Informasi Kesehat-an Situasi Penyakit Kanker. Igarss; 2015. 1, p. 1-5.
Achmadi, Brahmana AT, Suhatno. Karakteristik Penderita Kanker Serviks 2006-2010 di RSUD dr. Soetomo. Majalah Obstetri & Ginekologi. 2011;18 (3): 28–33.
de Sanjosé S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical HPV in women with normal cytology. Lancet Infect Dis. 2007;7(7):453-9.
Bosch FX and de Sanjose S. Cervical human papil-lomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological fin-dings. The Journal of infectious diseases. 2010;202 (12):1789–99.
Stanley M/ HPV-immune response to infection and vaccination. Infectious Agents and Cancer. 2010;5: 19.
Coutlee F, Ratnam S, Ramanakumar AV et al. A clinically relevant, syngeneic model of spontan-eous, highly metastatic B16 mouse melanoma. Anticancer Research. 2010;30(12): 4799–804.
Jancar N, Kocjan BJ, Poljak M et al. Distribution of human papillomavirus genotypes in women with cervical cancer in. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2016; 145:184–8.
Tobing MDL, Edhyana S, Dinda M, et al. Human papillomavirus genotypes profile in cervical cancer patients at dr. Hasan Sadikin general hospital, Bandung, Indonesia. Asian Pacific journal of cancer prevention. 2014;15(14):5781–5.
Clifford GM, Smith JS, Plummer M, Munoz NFS. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. British Journal of Cancer. 2003;88(1):63–73.
Bao YP, Li N, Smith J, Qiao YL. Human papillo-mavirus type distribution in women from Asia: A meta-analysis. International Journal of Gynecolo-gical Cancer. 2008;18(1):71–9.
Xu XX, Zhou JS, Yuan SH, Yu H. Distribution of HPV Genotype in Invasive Cervical Carcinoma and Cervical Intraepithelial Neoplasia in Zhejiang Pro-vince, Southeast China : Establishing the Baseline for Surveillance. Int. J. Environ. Res. Public Health. 2015:10794–805.
Li Y, Peng L, Seto E., 2015. Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway. Molecular and cellular biology, 35(20), pp.3547–65.
Hadzisejdic I, Simat M, Bosak A. Prevalence of human papillomavirus genotypes in cervical cancer and precursor lesions. Coll. Antropol. 2006; 30(11): 879–83.
Tornesello ML, Losito S, Benincasa G, et al. Human papillomavirus (HPV) genotypes and HPV16 variants and risk of adenocarcinoma and squamous cell carcinoma of the cervix. Gyneco-logic Oncology. 2001;121(1):32–42.
Odida M, de Sanjose S, Quint W et al. Human Papillomavirus type distribution in invasive cervic-al cancer in Uganda. BMC Infectious Diseases. 2008;7:1–7.
Pirog EC, Lloverans B, Molijn A et al. HPV preva-lence and genotypes in different histological subtypes of cervical adenocarcinoma , a worldwide analysis of 760 cases. Modern Pathology. 2014; (27):1559–67.
Pirog EC, Kleter B, Olgac S, et al. Prevalence of human papillomavirus DNA in different histologic-al subtypes of cervical adenocarcinoma. The Ame-rican Journal of Pathology. 2000;157(4):1055–62.
Sykes P, Gopala K, Tan AL, et al. Type distribution of human papillomavirus among adult women diagnosed with invasive cervical cancer (stage 1b or higher) in New Zealand. BMC Infectious Diseas-es, 2014:14(374);1–9.
Burk RD, Terai M, Gravitt PE, et al. Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix. Cancer Research. 2003:11(12):7215–20.
Yoshida T, Sano T, Oyama T, et al. Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. Virchows Archiv. 2009;455(3):253–9.
Cullen AP, Reid R, Campion M, Lorinz AT. Ana-lysis of the physical state of different human pa-pillomavirus DNAs in intraepithelial and invasive cervical neoplasm. Journal of Virology. 1991:65(2); 606–12.
McCluggage WG, Pirog EC, De Souza SC et al. Cervical glandular neoplasias : Results from a Eu-ropean multinational epidemiological study infec-tious causes of cancer. International Journal of Cancer. 1991;20(5):2858–68.
Smith JS, Lindsay L, Hoots B, et al. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: A meta-analysis update. International Journal of Cancer. 2007;121(3):621–32.
Chan PKS, Cheung TH, Tam AOY, et al. Biases in human papillomavirus genotype prevalence assess-ment associated with commonly used consensus primers. International Journal of Cancer. 2006;118 (1):243–45.
Bosch FX, Lorincz A, Munoz N et al. The causal relation between human papillomavirus and cervi-cal cancer. J Clin Pathol 2002;55(4):244–65.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
