Comparison of Acute Level of CK After Five Weeks Eccentric vs Concentric High Intensity Strength Exercise in Healthy Subject

Hasni Hasni, Hening Laswati Putra, Nuniek Nugraheni

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Background: Musculoskeletal injuries both in sport and recreational activities, at each age level, can lead to immobilization. Injury and immobilization can lead to muscle strength decrease and deconditioning. These conditions can be addressed by provision of strength training therapy especially for people with low exercise tolerance such as the elderly and patients with chronic disease. Existing studies stated eccentric exercise can increase muscle strength with less energy expenditure compared to concentric exercise. However eccentric exercise can lead to muscle damage indicated with an acute CK level increase, and eccentric exercise has not been carried out regularly for post muscle injuries and deconditioned patients. The American College of Sport Medicine (ACSM) stated strength increase and muscle hypertrophy require high intensity load strengthening exercise with a minimum load of 70% 1 Maximum Repetition. The recommended load was given to the subjects in this research. Our pleriminary study intervention was well tolerated by healthy subjects.

Aim: Comparing acute CK level alteration in high intensity eccentric and concentric muscle strengthening exercise on untrained healthy subjects.

Methods: Randomized pre test and post test group design. Subjects of the study (n = 16) were untrained healthy males. CK level was evaluated by laboratory test.

Results: Our study showed decline of acute CK level in both groups with p value 0.65 and 0.76, respectively. No significant differences found on both groups.

Conclusion: The increase of acute CK level after five weeks of eccentric strengthening exercise is not higher than that in concentric strengthening exercise.


strengthening; eccentric; concentric; high intensity; creatin kinase

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Evetovich T, Ebersole K. (2006). Adaptations to Resistance Training. In: ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription 5thedn. Philadelphia: Lippincott Williams & Wilkins, pp. 325-335.

Yasuda. (2011). Combined effects of low-intensity blood flow restriction training and high-intensity resistance training on muscle strength and size. Arbeitphysiologie, pp.2525-33.

Hedayatpour N, Falla D. (2015). Physiological and Neural Adaptations to Eccentric Exercise: Mechanisms and Consideration for Training. Biomed Research International.

Panicker TJ, Muthukumaran J. (2017). Concentric versus eccentric strength training in elbow flexor strengthening. Int j Pharm Bio Sci, pp. 470-475.

Roig M, O’Brien K, Kirk G, Murray R. (2009). The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med;43, pp. 556–568.

Izquierdo M, Ibanez J, Calbet JA, Amezqueta IN, Izal MG, Idoate F, Hakkinen K, Kraemer WJ, Sarrasqueta MP, Almar, Gorostiaga EM. (2009). Cytokine and Hormone Responses to Resistance Training. Eur J Appl Physiol 107(4), pp. 397-409.

Clarkson PM, Hubal MJ. (2002). Exercise Induced Muscle Damage in Humans. Am. J. Phys. Med. Rehabil, 81 ( Suppl ), pp.52-69.

Baird MF, Graham SM, Baker JS, Bickerstaff GF. (2012). Creatine Kinase and Exercise Related Muscle Damage Implications for Muscle Performance and Recovery. Journal of Nutrition and Metabolic article ID 960363.

Koch AJ. Pereira R, Machado M. (2014). The Creatine Kinase Response to Resistance Exercise. J Musculoskelet Neurnal Interact 144(1), pp. 68-77.

Nosaka K, Clarkson PM. (1992). Relationship between post exercise plasma CK elevation and muscle mass involved in the exercise. Int J Sports Med; 13 (6): 471-5.

Scalco RS,Snoeck M. (2018). Exertional rhabdomyolysis: physiological response or manifestation of an underlying myopathy?. BMJ of Sport. Vol2, p.4.

Proske U, Morgan DL. (2001). Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications. Journal of Physiology, 537.2, pp.333–345.

Thiebaud RS. (2012). Exercise Induced Muscle Damage : Is It Detrimental or Beneficial?. Journal of Trainology 1: 36-44.

Brancaccion P, Maffulli N, Limongelli FM. (2007). Creatine Kinase Monitoring in Sport Medicine. British Medical Bulletin 81 and 82, pp. 209-230.

Machado M, Williardson JM. (2010). Short recovery augments magnitude of muscle damage in high responders. Medicine & science in sports & exercise, pp. 1370-1373.


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