Hubungan Kadar Antioksidan Superoxide Dismutase (SOD) dengan Indeks Bakterial (IB) pada Pasien Kusta Baru Tipe Multibasiler (MB) tanpa Reaksi
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Latar Belakang: Kusta merupakan penyakit infeksi kronik yang disebabkan oleh kuman Mycobacterium leprae (M. leprae). Tubuh memiliki beberapa mekanisme pertahanan untuk menghadapi infeksi bakteri M. leprae, diantaranya melalui scavenging dari radikal bebas, antioksidan enzimatik merupakan garis pertahanan pertama melawan reactive oxygen species (ROS). Superoxide dismutase (SOD) adalah salah satu enzim antioksidan utama yang menangkal radikal bebas. Terdapat perburukan status antioksidan pada pasien kusta yang berkorelasi dengan indeks bakterial (IB) dan spektrum kusta. Tujuan: Mengevaluasi hubungan antara kadar SOD dengan IB pada pasien kusta baru tipe multibasiler (MB) tanpa reaksi. Metode: Penelitian ini merupakan rancangan penelitian analitik observasional potong lintang yang bertujuan untuk mengetahui hubungan kadar SOD dengan IB pada pasien kusta baru tipe MB tanpa reaksi. Hasil: Rerata kadar SOD pada semua pasien 86,02±17,89. Kadar SOD pada IB negatif lebih rendah dibandingkan kadar SOD pada IB +1 sampai +3. Kadar SOD tertinggi didapatkan pada IB +1, dengan median IB 0 = 82,20, IB +1 = 92,10, IB +2 = 85,75 dan IB +3 = 82,94. Hasil uji korelasi menunjukkan tingginya kadar SOD tidak disertai dengan rendahnya nilai IB sehingga tidak terdapat hubungan yang signifikan antara kadar SOD dengan berbagai nilai IB dengan p = 0,909 (p>0,05) r= -0,022. Simpulan: Hasil uji korelasi menunjukkan tingginya kadar SOD tidak disertai dengan rendahnya nilai IB dan penelitian ini tidak terdapat hubungan yang signifikan antara kadar SOD dengan nilai IB.
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