Unusual Skin Metastasis from Gastric Cancer: A Case Report
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Background: Skin metastasis from gastric cancer are relatively rare, but they have important clinical significance because they usually indicate a worse prognosis. Skin metastasis from gastric cancer may spread through lymphatic ducts, blood vessels in the ligamentum teres, contiguous extension, or embryologic remnants of the umbilicus. Purpose: To report an unusual skin metastasis from gastric cancer that clinically resembles as a benign lesion of skin papules. Case: A rare metastasis from gastric cancer origin in a 61-year-old male in the abdominal skin. Gastric cancer metastasis in an unusual site such as the abdominal skin often resembles as dermatitis, especially in the early course of metastatic spreading, which looked like common papules on the skin. Discussion: In the beginning, the skin papules were not suspected to be a metastatic process because there was no palpable or no tenderness in the subcutan or fascia underneath. The appearance resembled common dermatitis. However, as papules rapidly spread to the surrounding skin, the malignancy was then suspected. The incisional biopsy from the papules was performed and showed that it was metastatic diffuse-type gastric adenocarcinoma. Conclusion: The skin metastasis was different from general nodules, but rather as skin papules of general dermatitis in initial appearance. The surgeon and dermatologist should be alert if they find any benign appearance of a skin lesion on the abdominal wall in a patient with a history of gastric cancer surgery.
Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. Metastatic spread in patients with gastric cancer. Oncotarget 2016; 7(32): 52307-16.
Raka M, Bazzi N, Haidar A, El Safadi A, Chahine G. Metachronous Skin Metastasis of Gastric Cancer: Case Report. JOJ Case Stud 2019; 10(4): 555793.
Avgerinou G, Flessas I, Hatziolou E, et al. Cutaneous metastasis of signet-ring gastric adenocarcinoma to the breast with unusual clinicopathological features. Anticancer Res 2011; 31(6): 2373–78.
Abbasi F, Abbas A, Mahmodlou R, Mehdipour E. Cutaneous metastasis of gastric carcinoma: A rare case with unusual presentation site. Indian J Dermatopathol Diagn Dermatol 2018; 5:54-6.
Liu F, Yan WL, Liu H, Zhang M, Sang H. Cutaneous metastasisfrom gastric adenocarcinoma 15 years after curative gastrectomy. An Bras Dermatol 2015; 90(3 Suppl 1): 46–50.
Piura B. Umbilical metastasis: Sister Mary Joseph's nodule. Harefuah 2006; 145(7): 505–550.
Al Ani AH, Totah E, Al Ani A. Sister Joseph Nodule the Durable Sign. General Med 2015; 3(2): 178.
Rita V, Rahul K. Kota N, Diwan, Nidhi B. Jivani, and Shailee S. Skin: A mirror of internal malignancy Indian J Med Paediatr Oncol. 2019; 37(4): 214–22.
Manuela C, Michele M, Valeria B, Chiara B, Roberta S, Gabriele D, Andrea W, Corrado C, Franco D. Cutaneous Metastasis From Primary Gastric Cancer: A Case Report and Review of the Literature. Cutis 2014; 93: E9-E13.
Lookingbill DP, Spangler N, Helm KF. Cutaneous metastasisin patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993; 29(2 Pt 1): 228–36.
Kim D, Park Y, Joo J, Ryu S, Kim Y, Kim S and Lee J. Clinicopathological characteristics of signet ring cell carcinoma of the stomach. ANZ J Surg 2004; 74: 1060-64.
Sánchez-Muñoz A, Gravalos Castro C, Colomer Ryota K, Yoshiaki M, Nozomi M, Toshiki S, Tomonori H. Late Cutaneous Metastasis Originating from Gastric Cancer with Synchronous Metastasis. Case Rep Gastroenterol 2019; 13: 95–101.
Luo W, Fedda F, Lynch P, Tan D. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment. Front Pharmacol 2018; 9: 1421.
Ryota K, Yoshiaki M, Nozomi M, Toshiki S, Tomonori H. Late Cutaneous Metastasis Originating from Gastric Cancer with Synchronous Metastasis. Case Rep Gastroenterol 2019; 13: 95–101.
Luo W, Fedda F, Lynch P, Tan D. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment. Front Pharmacol 2018; 9: 1421.
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