The Efficacy of Topical Vitamin C and Microneedling for Photoaging
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Background: Photoaging is premature skin aging caused by exposure to ultraviolet (UV) radiation. Vitamin C is an antioxidant that inhibits the tyrosinase enzyme that can reduce pigmentation. Microneedling procedure can improve the penetration of topical vitamin C, and it has skin rejuvenating effects to reduce wrinkles and minimize pore size. Purpose: The main purpose of this study was to evaluate the efficacy of topical vitamin C application after microneedling intervention for the clinical improvement of photoaging. Methods: Twenty-four women with photoaged skin participated in this randomization study, and they were divided into control and intervention groups. Solution of 0.9% NaCl and microneedling were performed to control group, and topical vitamin C and microneedling were performed to intervention group. Three intervention sessions were repeated at a 2 week interval. Signs of photoaging such as pigmentation, wrinkles, and pores were evaluated using Metis DBQ3-1, and the data were obtained numerically. Result: The data analysis revealed a significant improvement in pigmentation in the intervention group compared to control group (p<0.05). Wrinkles and pores evaluation revealed no significant difference between the control and intervention groups. Conclusion: Topical vitamin C after microneedling procedure has provided a significant improvement in pigmentation compared to NaCl 0.9% after microneedling.
Helfrich YR, Sachs DL, Voorhees JJ. Overview of skin aging and photoaging. Dermatol Nurs 2008; 20(3): p. 177-83.
Masaki, H. Role of antioxidants in the skin: Anti-aging effects. J Derm Sci 2008; 1: p. 85-90.
Baumann. Sodium Ascorbyl Phosphate. 2005. Accessed 2019 October 21 from http://www.dr-baumann-international.co.uk/science/BASF%20 Vitamin %20C.pdf
Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol 2003; 48(6): p. 866–74.
Nair PA, Arora TH. Microneedling using dermaroller a means of collagen induction therapy. Gujarat Medical Journal 2014; 69: p. 24-7.
Loesch MM, Somani AK, Kingsley MM, Travers JB, Spandau F. Skin resurfacing procedures: new and emerging options. Clin Cosm Invest Dermatol 2014; 7: p. 231-41.
Makino ET, Jiang LI, Priscilla Tan BA, Cheng, Tsing, Mehta, Rahul. Áddressing male facial skin concerns: clinical efficacy of a topical skincare treatment product for men. J Drugs Dermatol 2018; 17(3): p. 301-6.
Pratiwi, Murtiastutik, Prakoeswa. Efek pemberian topikal produk metabolit amniotic membrane stem cell (PM-AMSC) pada penuaan kulit. Berkala Ilmu Kesehatan Kulit dan Kelamin 2018; 30(2): p. 96-101.
El-Domyati M, Attia S, Saleh F, Brown D. Intrinsic aging vs photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol 2018; 11: p. 398-405.
Chien AL, Qi J, Grandhi R. Photoaging in african-american skin: a reliable photonumeric scale reveals age, male gender, and sun exposure as contributory factors. J Invest Dermatol 2015; 135: p. 28.
Taylor SC. Photoaging and pigmentary changes
of the skin. In: Buergess (ed.). Cosmetic Dermatology. Berlin: Springer 2005; p. 29-49.
Shimada. Effects of Ascorbic Acid on Gingival Melanin Pigmentation. J Periodontol 2009; 80(2): p. 317-23
Tobin DJ. Introduction to skin aging. J Tissue Viability 2017; 26(1): p. 37–46.
Knaggs H. Skin aging in the Asian population. In: Dayan, N (ed.). Skin Aging Handbook. New York: William Andrew Publishing. 2009: p. 177-201.
Effendy ZF. Efikasi pemberian topikal campuran produk metabolic amniotic membrane stem cell (AMSC) dan vitamin C setelah microneedling pada photoaging. Surabaya: Universitas Airlangga. 2017: p. 25-37.
Vasconcelos EM, Takano D. Microneedling: experimental study and classification of the resulting injury. Surg Cosmet Dermatol 2013; 5(2): p. 1104.
Farris. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 2006; 31: p. 814–818.
Liebl H, Kloth LC. Skin cell proliferation stimulated by microneedles. J Amer College Clin Wound Specialists 2012; 4(1), p. 2–6.
Ichihashi M, Ando H, Yoshida M, Niki Y, Matsui M. Photoaging of the skin. Anti-Aging Medicine 2009; 6(6): p. 46–59.
Zheng Q, Chen S, Chen Y, Lyga J, Wyborksi R, Santhanam U. Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study. Clin Cosmet Investig Dermatol 2013; 3: p. 317-25.
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