Efficacy and Side Effects of Fractional Carbon Dioxide Laser for Acne Scars, Keloids, and Striae Albae in the Dermatovenereology Clinic of Tertiary Hospital: A Retrospective Study
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Background: Fractional Carbon Dioxide (CO2) LASER has better efficacy compared to conventional LASER in treating scar tissue such as acne scars, keloids, and striae albae. However, a population with darker skin has a higher risk of side effects, especially in post-inflammatory hyperpigmentation. Purpose: To evaluate the efficacy and side effects of fractional CO2 LASER in new patients with acne scars, keloids, and striae albae in the Dermatovenereology outpatient clinic. Methods: Retrospective analysis was done on 42 medical records of patients who met the inclusion criterion, which was those who have undergone fractional CO2 LASER treatments. The efficacy and side effects of the therapy were identified and analyzed using the Statistical Package for Social Sciences (SPSS) version 17 program. Result: A total of 42.9% of patients underwent fractional CO2 LASER treatments for acne scars, while 31% and 26.1% of patients received treatments for keloids and striae albae, respectively. There was a statistically significant decrease in the degree of acne scar (2.72 ± 0.83), keloid height (2.2 ± 0.405), and striae width (0.39 ± 0.02). The statistically significant side effects were hyperpigmentation (59.5%), crustae (26.2%), erythema ≥ for 4 days (19%), and new acne (19%). Conclusion: Fractional CO2 LASER was effective for treating scar tissue (acne scars, keloids, and striae albae) with a higher incidence of side effects in population with darker skin and post-inflammatory hyperpigmentation.
Saedi N, Jalian HR, Petelin A, and Zachary C. Fractionation: Past, Present, Future. In: Seminars in Cutaneous Medicine and Surgery. Chicago: Elsevier 2012; p.138-60.
Patil UA, Dhami LD. Overview of LASERs. Indian J Plast Surg 2012; 41(3): S101-13.
Busse B. Introduction to wound healing. In: Busse B. Editor Wound management in urgent care. Philadelphia: Springer International Publishing 2016; p. 1-5.
Falanga V, Imamoto S. Mechanisms of wound repair, wound healing, and wound dressing. In: Goldsmith LA, Katz SI, Gilchrist BA, Paller AS, Leffel DJ, Wolff K, editor-editor. Fitzpatrick’s Dermatology in general medicine. 8th edition. New York: Mc Graw Hill Companies 2012; p. 2984-96.
Alves RO, Boin MFC, Crocco EI. Striae after topical orticosteroid: treatment with nonablative fractional LASER 1540nm. J Cosmet Ther 2015; 93(2):1-5.
Clementoni MT, Lavagno R. A novel 1565 nm non-ablative fractional device for stretch marks: a preliminary report. J Cosmet LASER Ther 2015; 89:1–8.
Chapas AM, Brightman L, Sukal S. Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med 2011; 40(06):381–6.
Harumi O, Tan L, Tan WP, GOH CL. Treatment of facial acne scarring with fractional carbon dioxide laser in Asians, a retrospective analysis of efficacy and complications. Dermatol Surg 2017; 0: 1-7.
Lee SM, Kim MS, Kim YJ, Won CH, Lee MW, Choi JH et al. Adverse Event of Non Ablative Fractional Photothermolysis: A Retrospective of Study 856 Treatment in 362 Patient. Int Jl of Dermatol 2014; 25(4):304-7.
Naeini FF, Nikyar Z, Mokhtari F, Bahrami A. Comparison of the fractional CO2 laser and the combined use of a pulsed dye laser with fractional CO2 laser in striae alba treatment. Adv Biomed Res 2014; 3: 184-6.
Kaur J, Sharma S, Kaur T, Bassi R. Complications of fractional ablative carbon dioxide laser in various aesthetic procedures: a retrospective study. Int J Res Dermatol 2019; 5(4): 664-7.
Lee SM, Kim MS, Kim YJ, Won CH, Lee MW, Choi JH et al. Adverse Event of Non Ablative Fractional Photothermolysis: A Retrospective of Study 856 Treatment in 362 Patient. Int Jl of Dermatol 2014; 25(4):304-7.
Huang L. A new modality for fractional CO2 laser resurfacing for acne scars in Asians. Lasers Med Sci 2013; 28(02): 627–32.
Magnani LR, Schweiger ES. Fractional CO2 lasers for the treatment of atrophic acne scars: a review of the literature. J Cosmet Laser Ther 2014; 16(02): 48–56.
Fabbrocini G, Annunziata MC, Arco VD, Vita VD, Lodi G, Mauriello MC et al. Review article: Acne scars: pathogenesis, classification and treatment. Dermatol research 2010; 129(9): 2136-41.
Gonzales DFM, Navalta JTP. The efficacy and safety of fractional ablative resurfacing using 10,600nm CO2 pulse wave in the treatment of striae distensae among filipino women with skin types III-V, a preliminary investigation and initial results. Am J Clin Dermatol 2012; 19(3): 405-23.
Crocco EI, Mantovani PA, Volpini BMF. In search of treatments for striae rubra and striae alba: a dermatologists’ challenge. Surg Cosmet Dermatol 2012; 4(4): 332-7.
Al-Himdani S, Ud-Din S, Gilmore S, Bayat A. Striae distensae: A comprehensive review and evidencebased evaluation of prophylaxis and treatment. Br J Dermatol 2014; 170(3): 527-47.
Reinke MJ, Sorg H. Wound repair and regeneration. European Surg Reasearch 2012; 35-43.
Scrimali L, Lomeo G, Nolfo C, Pompii G, Tamburino S, Catalani A. Treatment of hyperthrophic scar and keloids with fractional CO2 laser: a personal experience. J Cosmet Laser Ther 2010; 12:218-21.
Emmy MG, Tanzi EL, Alster TS. Side effects and complications of fractional laser photothermolysis: Experience with 961 treatment. Dermatol surg 2011; 34: 301-7.
Ryu HW, Kim SA, Jung HR, Ryoo YW, Lee KS, Cho JW. Clinical improvement of striae distensae in korean patients using a combination of fractionated microneedle radiofrequency and fractional carbon dioxide LASER. Dermatol Surg 2013; 11(12): 12108-17.
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