The Burden of Leprosy Reaction in the Post-Elimination Era: A Study from Gresik City, Indonesia
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Background: The attention of leprosy management has shifted to reduce the burden of leprosy complications, including leprosy reactions. Leprosy reaction is the predominant cause of nerve impairment that leads to disability and lowers the quality of life of the affected. Purpose: The aim of this study was to provide primary data about leprosy reaction epidemiology, risk factor, and outcomes in the post-elimination era. Methods: A cross-sectional study was held in a general hospital in Gresik City, Indonesia, to give clinical demography, risk factors, and outcomes of leprosy reaction. Result: New leprosy reaction cases remain detected each year. There were 57 (58.8%) out of 97 leprosy patients who had a reactional episode. The incidence of leprosy reactions has been increasing in the last three years. The multibacillary (MB) group and type 2 reactions dominated leprosy reactions, which mostly occurred in the young adult population. Some of the leprosy reaction patients had developed a complication due to prolonged steroid usage. Conclusion: Leprosy cases in a young population with a high risk of developing reaction episodes need collaboration in the management to prevent deformity in youth.
Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy reaction in Thai population : a 20-year retrospective study. Dermatology Research and Practice 2015; 2015.
Putri AI, Sabbata K De, Agusni RI, Alinda MD, Darlong J, Barros B De, et al. Understanding leprosy reactions and the impact on the lives of people affected : An exploration in two leprosy endemic countries. PLoS Neglcted Tropical Disease 2022;16(6):1–20.
Wibawa T, Satoto TBT. Magnitude of neglected tropical diseases in indonesia at postmillennium development goals era. Journal of Tropical Medicine 2016; 2016.
Alinda MD, Geani S, Agusni RI, Kusumaputra BH, Reza NR, Prakoeswa CRS, et al. Diagnosis and management of leprosy. Berkala Ilmu Kesehatan Kulit dan Kelamin 2020;32(2):149.
Samsudin DD, Karyanti MR. Atypical clinical manifestations of leprosy in indonesian male adolescent: A case report. Paediatrica Indonesiana(Paediatrica Indonesiana) 2021;61(3):175–8.
Menaldi SL, Harini M, Nelfidayani N, Irawati Y, Setiono S, Wahyuni LK, et al. Functional activity limitation of leprosy cases in an endemic area in Indonesia and recommendations for integrated participation program in society. PLoS Neglected Tropical Disease 2022;16(8).
Ramadhona A, Supriyanto S, Martini S. Prevention effort of leprosy reactions based on risk factor analysis at sumberglagah leprosy hospital mojokerto. KnE Life Sciences 2018;4(9):161.
Flora RSP, Sutrisna E. Leprosy: An overview of epidemiology and risk factor in indonesia. Journal of Bio Innovation 2017;6(6):991–5.
Rosdiana B, Astari L, Astindari A, Prakoeswa CRS, Zulkarnain I, Damayanti D, et al. Risk factors of type 1 leprosy reaction in leprosy patients attending leprosy division of dermatology and venereology outpatient clinic of dr soetomo general hospital in 2017–2019: A retrospective study. Open Access Maced J Med Sci 2021;9:1359–63.
Chen X, Liu HB, Shui TJ, Zha S. Risk factors for physical disability in patients with leprosy disease in yunnan, china: Evidence from a retrospective observational study. PLoS Negl Trop Dis 2021;15(11):1–14.
Quyum F, Hasan M, Chowdhury WK, Wahab MA. Leprosy Reactions: Frequency and risk factors. Journal of Clinical Dermatology & Therapy 2016;3(1):1–3.
Mowla MR, Ara S, Mizanur Rahman AFM, Tripura SP, Paul S. Leprosy reactions in postelimination stage: the Bangladesh experience. Journal of the European Academy of Dermatology and Venereology 2017;31(4):705–11.
Raffe SF, Thapa M, Khadge S, Tamang K, Hagge D, Lockwood DNJ. Diagnosis and treatment of leprosy reactions in integrated services - The patients' perspective in nepal. PLoS Negl Trop Dis 2013;7(3):1–6.
Scollard DM, Martelli CMT, Stefani MMA, Maroja MDF, Villahermosa L, Pardillo F, et al. Risk factors for leprosy reactions in three endemic countries. The American Journal of Tropical Medicine and Hygiene 2015;92(1):108–14.
Voorend CGN, Post EB. A systematic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction. PLoS Negl Trop Dis 2013;7(10).
Motta ACF, Pereira KJ, Tarquı DC, Vieira MB, Foss NT. Leprosy reactions : coinfections as a possible risk factor 2012;67(10):1145–8.
Geani S, Rahmadewi, Astindari, Prakoeswa CRS, Sawitri, Ervianti E, et al. Risk factors for disability in leprosy patients: a cross-sectional study. Bali Medical Journal 2022;11(1):197–201.
Shah UH, Jadwani MM, Raju SP, Ladani PH, Bhuptani N V. Clinical and histopathological features in lepra reaction: a study of 50 cases. International Journal of Research in Dermatology 2019;5(2):382.
Pandhi D, Chhabra N. New insights in the pathogenesis of type 1 and type 2 lepra reaction. Indian J Dermatol Venereol Leprol 2013;79(6):739–49.
Khatu SS, Palaskar NM, Balpande GL, Chaudhari ND. Resurgence of leprosy in post elimination era. International Journal of Research in Dermatology 2019;5(4):743.
Rao TVN, Talluri A. Clinico-epidemiological study of childhood leprosy in post elimination period at a tertiary care hospital. International Journal of Contemporary Medical Research [IJCMR] 2019;6(12):51–5.
Hambridge T, Chandran SLN, Geluk A, Saunderson P, Richardus JH. Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review. Vol. 15, PLoS Neglected Tropical Diseases 2021. 1–32 p.
Earlia N, Budini SS, Ramadana DS, Bulqiah M, Tasrif AY, R RR, et al. The profile of leprosy patients in aceh: Retrospective study. Berkala Ilmu Kesehatan Kulit dan Kelamin 2022;34(1):46–51.
Antunes DE, Santos DF, Lima MIS, Caixeta LP, Correa MBC, Moraes EC dos S, et al. Clinical, epidemiological, and laboratory prognostic factors in patients with leprosy reactions: A 10-year retrospective cohort study. Front Med (Lausanne) 2022;9.
Bath RM, Vaidya TP. What is new in the pathogenesis and management of erythema nodosum leprosum. Indian Dermatol Online J 2020;11(4):482–92.
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