The Association between The Degree of Liver Cirrhosis Severity and Zinc Serum Level
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Background: Impaired liver function in LC (Liver Cirrhosis) can cause Zinc deficiency (Zn). One of the causes of Zn deficiency in LC is decreased albumin synthesis, whereas albumin is required as the main Zn binding protein in plasma. However, some studies of the severity of LC with Zn serum levels still provide controversial results.
Objective: To determine the association between the degree of LC severity and Zn serum level.
Methods: The subjects of this study were LC patients in Gastroentero-Hepatology Unit and Internal medicine wards in of Dr. Soetomo General Hospital Surabaya for three months. Diagnosis of LC was based on clinical examination according to Soehardjno-Soebandiri criteria and other findings (ultrasound or endoscopy). The degree of LC severity was determined based on the CTP score (Child-Turcotte-Pugh). Serum Zn concentration was measured by atomic absorption spectrophotometry method. The research design used the cross-sectional method. The statistical test used was Spearman correlation.
Results: Forty-three patients fulfilled the study criteria. The subjects consisted of 27 males (62.8%) and 16 females (37.2%) with the mean age of 53.81 ± 8.67 years. Based on the CTP scores, we obtained CTP A of 4 patients (9.3%), CTP B of 19 patients (44.2%) and CTP C of 20 patients (46.5%). The mean of Zn serum level in CTP A, CTP B, and CTP C score was 58.3 ± 19.6 μg/dl, 43.4 ± 14.5 μg/dl and 31.6 ± 10 μg/dl respectively. The result of the statistical test showed a significant correlation between LC severity and Zn serum level (p <0.05 and r = -0.583).
Conclusion: The heavier the severity of LC, the lower Zn serum levels.
Bacon BR, 2008. Cirrhosis and its complications. In (Longo DL,Fauci AS). Harrison's Gastroentrology and Hepatology, 17th edition,The United States, McGraw-Hill Companies,419-434.
Blachier M, Leleu H, Radosavljevic J,2013. The burden of liver disease in europe a review of available epidemiological data. European Association for the Study of the Liver Journal; 8-12.
Durand F and Valla D, 2005. Assessment of the prognosis of cirrhosis: Child–Pugh Versus MELD. Journal of Hepatology; 42 : 100–107.
a. Evans G, 2006. Zinc and its deficiency diseases. Clincal Physiology Biochem; 4:94-8.
Heidelbaugh JJ and Sherbondy M, 2006. Cirrhosis and chronic liver failure. Part II: Complications and treatment. American Family Physician, 74:765-779.
Iwata K, Enomoto H, Nishiguchi S, Sato N and Aiwa N, 2014. Serum zinc value in patients with Hepatitisvirusrelated chronic liver disease: associationwith the histologicaldegree of liver fibrosis andwith the severity of varices in compensated cirrhosis. Journal Clinical Biochem Nutrition, 2 : 147–152.
Kusumobroto HO, 2012. Sirosis hati. Editor : Sulaiman HA, Akbar HN, Lesmana LA. Buku Ajar Ilmu Penyakit Hati. Edisi ke-1 revisi, JakartaCV Sagung Seto,347-356.
Maher M, Tarek M, Yosef A , Alkady H, 2013. Hyponatremia and zinc deficiency as a risk factor for hepatic encephalopathy in cirrhotic patients. Life Science Journal, 10 : 3-10.
Nurdjanah S, 2009. Sirosis hati. Editor: Sudoyo WA, Setiyohadi B, Alwi I, Simadibrata M, Setiati S. Buku Ajar Ilmu Penyakit Dalam, Edisi ke-3, Jakarta Pusat Penerbitan Departemen Ilmu Penyakit Dalam FK – UI, 668-676.
Somi MH, Rahimi AO, Moshrefi B, Rezaeifar P, 2007. Nutritional Status and Blood Trace Elements in Cirrhotic Patients. Hepatitis Mouthly, 7: 27-32.
Soomro AA, Devrajani BR, Shaikh K , 2009. Serum zinc level in patient with liver cirrhosis. Pakistan Journal Medicine Science, 5: 16-26.
Triwikatmani C, Bayupurnama P, Maduseno S, 2009. Serum zinc level and urinary zinc excretion in patient with liver cirrhosis. TheIndonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 4: 305-311.
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