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Caesarean section is the delivery through a surgical incision in the abdomen and uterus with various risks, such as Surgical Site Infection (SSI) which either occurs rapidly (24-48 hours postoperatively) or delayed. To reduce the risk of various post-cesarean section infections, prophylactic antibiotics are given. The administration of prophylactic antibiotics with recommended regimens, such as in developed countries as in the United States and Europe, with first generation of cephalosporins has not been applied in Dr. Iskak Hospital, Tulungagung. This hospital still used other types of antibiotics, such as cefotaxime or ceftriaxone. In addition, for several reasons, prophylactic antibiotics were continued with other antibiotics to reduce the risk of delayed infection. This study was designed to analyze the effectiveness of prophylactic antibiotics as recommended in cesarean section. This was a prospective observational study with consecutive sampling type, examined 41 mothers with cesarean section at the Department of Obstretics and Gynecology, Dr. Iskak Hospital, Tulungagung, Indonesia. This study was conducted from May to July, 2017. The results of the study showed that the effectiveness of prophylactic antibiotic use was 98% based on the clinical parameters and maternal laboratory outcome, which showed that SIRS was in normal category. Whereas, there was one mother (2%) who had SSI on day 10 postoperatively.


Prophylactic antibiotics cesarean section SIRS SSI

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How to Cite
Muzayyanah, B., Yulistiani, Y., Hasmono, D., & Wisudani, N. (2018). Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery. Folia Medica Indonesiana, 54(3), 161–166.


  1. Anderson DJ, Sexton DJ (2017). Antimicrobial prophylaxis for prevention of surgical site infection in adults. Available from Accessed on February 10, 2017, 1-37
  2. APhA (2013). Drug information handbook a comprehensive resource for all clinicians and health-care prefessionals 22th editions. Ohio, Lexi-comp
  3. Berghella V (2016). Cesarean delivery: Preoperative issues. Available at: Accessed on February 10, 2017, 1-25
  4. Bratzler DW, Dellinger EP, Olsen KM, et al (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. American Journal of Health-System Pharmacy 70, 195-283
  5. Chileshe E (2014). Determination of C-reactive protein levels in blood of post caesarean section mothers at the University Teaching Hospital, Lusaka. Dissertation University of Zambia, 1-35
  6. Clifford V, Daley A (2012). Antibiotic prophylaxis in obstetric and gynaecological procedures: A review. Australian and New Zealand Journal of Obstetrics and Gynaecology 52, 412-419
  7. Cunningham FG, Leveno KJ, Bloom SL, et al (2010). Williams Obstetrics, Twenty-Third Edition. The United States of America, The McGraw-Hill Companies, Inc, p 587-608
  8. Levison ME, Levison JH (2009). Pharmacokinetics and pharmacodynamics of antibacterial agents. Infectious Disease Clinics of North America 791-815
  9. Nightingale CH, Ambrose PG, Drusano GL, et al (2007). Antimicrobial pharmacodynamics in theory and clinical practice, second edition. New York, Informa Healthcare, p 129-146
  10. Schalkwyk JV, Eyk NV (2010). Antibiotic prophylaxis in obstetric procedures. SOGC Clinical Practice Guideline. Juornal of Obstetrics and Gynecology Canada, 878-884
  11. Smaill FM, Gyte GML (2010). Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database of Systematic Reviews, 1-176
  12. Ullman MA, Rotschafer JC (2016). Antimicrobial prophylaxis in surgery. In Chisholm-Burns MA. Schwinghammer TL, Wells BG, et al. Pharmacotherapy Principles & Practice Fourth Edition. New York, McGraw-Hill Education, p 1247-125

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