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Abstract

Highlight:

  1. Ethanol extract of Garcinia mangostana L. peel reduce malondialdehyde.
  2. Garcinia mangostana L. peel extract can increase non-radical products which impact in decreasing LDL cholesterol and increasing HDL cholesterol.
 

Abstract:

Atherosclerosis contributes to coronary heart disease which may lead to fatality. High cholesterol consumption, stress, and smoking can increase LDL cholesterol in the blood. Consumption of unsaturated fats, high fiber foods, exercise, quitting smoking, losing weight, and giving hypolipidemic drugs, especially herbs, can increase HDL cholesterol and decrease LDL cholesterol. Garcinia mangostana L. peel  extract can decrease LDL cholesterol by increasing reverse HDL cholesterol transport to the liver. The study used post test control group design. This study was experimental laboratory research with population of hypercholesterolemic male white mice aged 3-4 weeks with 100-200 grams weight. The HDL and LDL cholesterol data were collected through an enzymatic method by spectrophotometer. This study used analysis of variance (Anova) with significance level of α <0.05. The experiment divided the subjects into positive and negative control groups with dosage variations of 50, 150, 250, and 350 mg/kgBW.  Examination of hypercholesterolemia in white mice was conducted on the 8th day. The examination of HDL and LDL cholesterol given peel extract of Garcinia mangostana L. was conducted on the 22nd day. The analysis showed that giving Garcinia mangostana L. peel extract for various dosages could significantly decrease LDL cholesterol and increase HDL cholesterol (p <0.05). Peel extract of Garcinia mangostana L. that contained mangosteen could increase non-radical products that could prevent the transfer of ester cholesterol from HDL to VLDL which impact in increasing HDL cholesterol and decreasing LDL cholesterol.

Keywords

Garcinia mangostana L peel extract LDL cholesterol HDL cholesterol hypercholesterolemia health risk

Article Details

How to Cite
As’ari, H. (2021). Decrease of LDL Cholesterol Through The Increase of HDL Cholesterol by Administering Garcinia mangostana L. Peel Extract in White Mice. Folia Medica Indonesiana, 57(4), 298–302. https://doi.org/10.20473/fmi.v57i4.23728

References

  1. Ahn N, Kim K (2016). High-density lipoprotein cholesterol (HDL-C) in cardiovascular disease: effect of exercise training. Integrative Medicine Research 5, 212-215.
  2. Akbari A, Jelodar G, Nazifi S, et al (2016). An overview of the characteristics and function of vitamin C in various tissues: Relying on its antioxidant function. Zahedan Journal of Research in Medical Sciences 18, 1-9.
  3. Arozal W, Louisa M, Soetikno V (2020). Selected Indonesian medicinal plants for the management of metabolic syndrome: Molecular basis and recent studies. Front. Cardiovasc. Med 7, 1-16.
  4. Browns MS, Goldstein JL (2001). Drugs in the treatment of hypreproteinemias in good mean. Mc.Grraw-Hill Medical Publishing Division, New York.
  5. Carson JAS, Lichtenstein AH, Anderson CAM, et al (2019). Dietary cholesterol and cardiovascular risk: A science advisory from the American Heart Association. Circulation 141, e39-e53.
  6. Ghani L, Susilawati MD, Novriani H (2016). Faktor risiko dominan penyakit jantung koroner di Indonesia. Buletin Penelitian Kesehatan 44, 153-164.
  7. Hussain MA, Al Mamun A, Peters SAE, et al (2016). The burden of cardiovascular disease attributable to major modifiable risk factors in Indonesia. Journal of Epidemiology 26, 515-521.
  8. Liu AG, Ford NA, Hu FB, et al (2017). A healthy approach to dietary fats: Understanding the science and taking action to reduce consumer confusion. Nutrition Journal 16, 1-15.
  9. Macho-González A, Garcimartin A, Lopez-Oliva ME, et al (2019). Can carob-fruit-extract-enriched meat improve the lipoprotein profile, VLDL-oxidation, and LDL receptor levels induced by an atherogenic diet in STZ-NAD-diabetic Rats?. Nutrients 11, 1-16.
  10. Maisaroh S, Zahro C, Puspitosari DR, et al (2020). Effective consumption of garlic (allium sativum linn) on decreasing blood cholesterol levels. International Conference Earth Science & Energy 519, 1-9.
  11. Murray RK, Granner DK, Mayes PA, et al (2009). Harper's illustrated biochemistry-Twenty-six edition. Lange Medical Books/McGraw-Hill, United States of America.
  12. Polumbryk M, Ivanov S, Polumbryk O (2013). Antioxidants in food systems. Mechanism of action. Food Technology 1, 15-40.
  13. Pratiwi L, Fudholi A, Martien R, et al (2016). Ethanol extract, ethyl acetate extract, ethyl acetate fraction, and n-heksan fraction mangosteen peels (garcinia mangostana L.) as source of bioactive substance free-radical scavengers. Journal of Pharmaceutical Science and Clinical Research 1, 71-82.
  14. Raharjo LH, Monica M (2015). Pengaruh ekstrak kulit buah manggis terhadap total kolesterol, LDL, dan HDL serum pada tikus yang diberi minyak jelantah. Jurnal Ilmiah Kedokteran 4, 45-53.
  15. Sagar NM, McFarlane M, Nwokolo C, et al (2016). Mechanisms of triglyceride metabolism in patients with bile acid diarrhea. World Journal of Gastroenterology 22, 6757-6763.
  16. Sinulingga S, Putri HOV, Haryadi K, et al (2019). The effect of pindang patin intake on serum cholesterol and LDL levels of male mice (Mus Musculus L.). Sriwijaya International Conference on Medical Sciences 1246, 1-8.
  17. Snaebjornsson MT, Janaki-Raman S, Schulze A (2020). Greasing the wheels of the cancer machine: The role of lipid metabolism in cancer. Cell Metabolism 31, 62-76.
  18. Stephen JMP, William F (2012). Patofisiologi penyakit: Pengantar menuju kedokteran klinis - Edisi 5. EGC, Jakarta.
  19. Trajovska KT, Topuzovska S (2017). High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol. Anatol J Cardiol 18, 149-154.
  20. Viglianisi C, Menichetti S (2019). Chain breaking antioxidant activity of heavy (S, Se, Te) chalcogens substituted polyphenols 8, 1-22.
  21. Williams P, Ongsakul M, Proudfoot J, et al (1995). Mangostin inhibitits the oxidative modification of human low-density lipoprotein. Harwood Academic Publishers, United Kingdom.
  22. Wirasuta IMAG, Danuswari AAF, Larasanty LPF (2014). Kesesuaian informasi kontraindikasi obat gastrointestinal untuk pasien geriatri pada berbagai sumber informasi tersier. Acta Pharmaceutica Indonesia 39, 84-88.