Emulgel Formulation of Purified Extract of Moringa (Moringa oleifera L.) Leaf

Tutik Wuryandari, Nining Sugihartini, Kintoko Kintoko

= http://dx.doi.org/10.20473/fmi.v55i1.24329
Abstract views = 387 times | downloads = 332 times

Abstract


Moringa oleifera, known as moringa, is reported to have a high source of natural antioxidants, especially vitamin E. The formulation of purified Moringa leaf extract is needed so that the vitamin E content in it is more maximal. This study aimed to determine the levels of vitamin E in extracts after purification, physical property test of emulgel with variations in extract concentration and vitamin E levels in emulsions. The study was started from the extraction using maceration method with petroleum ether solvent, followed by extract purification using column chromatography with n-hexane solvent. The results of the purified extract were then formulated into emulgel with three concentrations of 3% (F1), 6% (F2) and 9% (F3). Emulgel was then evaluated for physical characteristics (pH, viscosity, adhesion, dispersion and stability). Determination of vitamin E levels was carried out on purified extract samples and on each formula. The results of non-specific standardization of extracts included ash content, acidic insoluble ash content were higher than those of Indonesian Herbal Pharmacopoeia literature and drying losses were lower compared to literature. Specific standardization of extracts was the content of vitamin E in 1.40% PE extract and 8.02% purified extract. In the test of emulgel physical characteristics, an increase in the concentration of the extract caused an increase in viscosity and decreased emulgel dispersion power. Whereas, tthe pH and sticky power remained the same. Storage hds an effect on decreasing the physical characteristics of emulsions especially on adhesion. Increased extracts also caused an increase in the levels of vitamin E in the purified extract of moringa leaf emulgel.

Keywords


Emulgel; Moringa oleifera; standardize extract; vitamin E

Full Text:

PDF

References


Anwar F, Latif S, Ashraf M, Gilani AH (2007). Moringa oleifera: A Food Plant with Multiple Medicinal Uses, Phytotherapy Research. Wiley InterScience 21, 17-25

Azizah B, Salamah N (2013). Standarisasi parameter non spesifik dan perbandingan kadar kurkumin ekstrak etanol dan ekstrak terpurifikasi rimpang kunyit. Jurnal Ilmiah Kefarmasian 3, 21-30

Dewi R, Anwar E, Yunita KS (2014). Uji stabilitas fisik formula krim yang mengandung ekstrak kacang kedelai (Glycine max). Pharm Sci Res 1, 194-208

Gaikwad, Kale (2011). Formulation and in vitro evaluation for sun protection factor of Moringa oleifera Lamarck (Family Moringaceae) oil sunscreen cream. International Journal of Pharmacy and Pharmaceutical Sciences, 3

Moyo B, Masika PJ, Hugo A, Muchenje, V (2011). Nutritional characterization of Moringa(Moringa oleifera Lam.) leaves. African Journal of Biotechnology 10, 12925-12933

Naibaho DH, Yamkan VY, Weni Wiyono (2013). Pengaruh basis salep terhadap formulasi sediaan salep ekstrak daun kemangi (Ocinum sanchum L.) pada kulit punggung kelinci yang dibuat infeksi Staphylococcus aureus. Jurnal ilmiah Farmasi – UNSRAT 2

Panwar AS, Upadhyay N, Bairagi M, Gujar S, Darwhekar GN, Jain DK (2011). Emulgel:a review. Asian Journal of Pharmacy and Life Science 1

Priani SE, Darusman F, Humanisya H (2014). Formulasi sediaan emulgel antioksidan mengandung ekstrak etanol kulit batang kayu manis (Cinnamomum burmanni Nees ex. BL.). Prosiding Seminar Nasional Penelitian dan PKM Sains, Teknologi, dan Kesehatan 4, 103-110

Sari DK, Sugihartini N, Yuwono T (2015). Evaluasi uji iritasi dan uji sifat fisik sediaan emulgel minyak atsiri bunga cengkeh (Syzigium aromatikum). Pharmaciana 5, 115-120

Smaoui S, Hilma HB, Chobba IB, Kadri A (2013) Development and stability studies of sunscreen cream formulations containing three photo-protective filters. Arabian Journal of Chemistry 10, 1216–1222

Winarsi H (2007) Antioksidan alami dan radikal bebas. Yogyakarta, Kanisius, p 11-19


Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Tutik Wuryandari, Nining Sugihartini, Kintoko Kintoko

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Indexed By

View My Stats

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.