Main Article Content
Abstract
TNF-alpha and stabilize atherosclerotic plaques. This study aims to determine the effect of atorvastatin 20 mg/day for 30 days in reducing the lipid profile and TNF-alpha inflammatory markers in patients with diabetes dyslipidemia. Diabetes patient with dyslipidemia who included the inclusion criteria in this observational prospective cohorts studies treated with atorvastatin for 30 days (n = 19). The efficacy of statin therapy was measured by lipid profiles (LDL, TG, HDL, and total cholesterol) and TNF-alpha. The results of the study showed that atorvastatin decreased 40.55% of LDL levels, 15.34% of TG levels, and 30.70% oftotal cholesterol levels which statistically significant (P <0.05). As for HDL, there is an increase of 6.06% but statistically non-significant (P >0.05). TNF-alpha levels increased by 11.30% which statistically non-significant (P >0.05). The use of atorvastatin 20 mg for 30 days gave reduction in LDL, TG, and total cholesterol and increased in HDL. Atorvastatin does not have a reducing effect on TNF-alpha. There was no correlation between lipid profile changes with TNF-alpha changes.
Keywords
Article Details
Copyright (c) 2021 Folia Medica Indonesiana
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
-
Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:
Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial ” You may not use the material for commercial purposes.
ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
You are free to :
Share ” copy and redistribute the material in any medium or format.
Adapt ” remix, transform, and build upon the material.
References
- ADA. (2017). Standards of Medical Care in Diabetes, Diabetes Care Journal, volume 40, supplement 1, january 2017.
- AHFS. (2011). AHFS Drug Information . Bathesda : American Society of Health System Pharmacists.
- Belliaa, A., Rizzaa, S., Gallia, A., Fabianoa, R., Donadela, G., Lombardoa, M. F., et al. (2010). Early vascular and metabolic effects of rosuvastatin compared with simvastatin in patients with type 2 diabetes . Atherosclerosis , 210, 199-201.
- Chehade, J. M., Gladysz, M., & Mooradian, A. D. (2013). Dyslipidemia in Type 2 Diabetes: Prevalence, Pathophysiology, and Management . Drugs , 73, 327- 339.
- Davignon, J. (2004). Beneficial Cardiovascular Pleiotropic Effects of Statins . Circulation , 109, III39–43 .
- Deerochanawong, C., Buranakitjaroen, P., Piamsomboon, C. (2007). The Atorvastatin Goal Achievement Across Risk Levels: (ATGOAL) Study in Thailand . Journal of the Medical Association of Thailand , 90 (1), 72-81.
- Grossman, A., & Grossman, E. (2017). Blood pressure control in type 2 diabetic patients. Cardiovascular Diabetololy , 16, 1-15.
- Lacy, C., Armstrong, L., Goldman, M., & Lance, L. (Eds.). (2016). Drug Information Handbook (24th ed.). New York: Lexicomp. 174-177.
- Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F. (2013). Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Diabetes and vascular disease , 2436-2446.
- PERKENI. (2015). Pengelolaan dan Pencegahan Diabetes mellitus Tipe 2 di Indonesia. 1-79.
- Schachter, M. (2004). Chemical, pharmacokinetic and pharmacodinamic properties of statin : an update. Blackwell Publishing Fundamental & Clinical Pharmacology, Vol. 19, p.117-125.
- Shaw, J. E., Sicree, R. A., Zimmet, P.Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 20130. Diabetes Research and Clinical Practice, vol 87, p.4-14.
- Stancu, C. (2001). Statins: mechanism of action and effects . Journal of Cellular and Molecular Medicine , 5 (4), 378-387.
- Triplitt, C., & Reasner, C. (2011). Diabetes mellitus. In e. a. Dipiro JT, Pharmacotheraphy : A Pathophysiology Approach. 8th Ed. New York: McGraw-Hill.
- Tousoulis, D., Oikonomou, E., Economou, E. K., Crea, F., & Kaski, J. C. (2015). Inflammatory cytokines in atherosclerosis: current therapeutic approaches. European Heart Journal , 1-13.
- Wu, L., & Parhofer, K. G. (2014). Diabetic dyslipidemia. Metabolism Clinical and Experimental , 63, 1468-1479.
- Zhou, Q., & Liao, J. K. (2010). Pleiotropic effects of statins: basic research and clinical perspectives . Circulation , 818-826
References
ADA. (2017). Standards of Medical Care in Diabetes, Diabetes Care Journal, volume 40, supplement 1, january 2017.
AHFS. (2011). AHFS Drug Information . Bathesda : American Society of Health System Pharmacists.
Belliaa, A., Rizzaa, S., Gallia, A., Fabianoa, R., Donadela, G., Lombardoa, M. F., et al. (2010). Early vascular and metabolic effects of rosuvastatin compared with simvastatin in patients with type 2 diabetes . Atherosclerosis , 210, 199-201.
Chehade, J. M., Gladysz, M., & Mooradian, A. D. (2013). Dyslipidemia in Type 2 Diabetes: Prevalence, Pathophysiology, and Management . Drugs , 73, 327- 339.
Davignon, J. (2004). Beneficial Cardiovascular Pleiotropic Effects of Statins . Circulation , 109, III39–43 .
Deerochanawong, C., Buranakitjaroen, P., Piamsomboon, C. (2007). The Atorvastatin Goal Achievement Across Risk Levels: (ATGOAL) Study in Thailand . Journal of the Medical Association of Thailand , 90 (1), 72-81.
Grossman, A., & Grossman, E. (2017). Blood pressure control in type 2 diabetic patients. Cardiovascular Diabetololy , 16, 1-15.
Lacy, C., Armstrong, L., Goldman, M., & Lance, L. (Eds.). (2016). Drug Information Handbook (24th ed.). New York: Lexicomp. 174-177.
Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F. (2013). Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Diabetes and vascular disease , 2436-2446.
PERKENI. (2015). Pengelolaan dan Pencegahan Diabetes mellitus Tipe 2 di Indonesia. 1-79.
Schachter, M. (2004). Chemical, pharmacokinetic and pharmacodinamic properties of statin : an update. Blackwell Publishing Fundamental & Clinical Pharmacology, Vol. 19, p.117-125.
Shaw, J. E., Sicree, R. A., Zimmet, P.Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 20130. Diabetes Research and Clinical Practice, vol 87, p.4-14.
Stancu, C. (2001). Statins: mechanism of action and effects . Journal of Cellular and Molecular Medicine , 5 (4), 378-387.
Triplitt, C., & Reasner, C. (2011). Diabetes mellitus. In e. a. Dipiro JT, Pharmacotheraphy : A Pathophysiology Approach. 8th Ed. New York: McGraw-Hill.
Tousoulis, D., Oikonomou, E., Economou, E. K., Crea, F., & Kaski, J. C. (2015). Inflammatory cytokines in atherosclerosis: current therapeutic approaches. European Heart Journal , 1-13.
Wu, L., & Parhofer, K. G. (2014). Diabetic dyslipidemia. Metabolism Clinical and Experimental , 63, 1468-1479.
Zhou, Q., & Liao, J. K. (2010). Pleiotropic effects of statins: basic research and clinical perspectives . Circulation , 818-826