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Abstract
Infection often occurs in children with malignant hematology and causes morbidity and mortality. Antibiotics should be given based on the results of culture and antibiotic susceptibility test. Ampicillin Sulbactam is a first-line drug in children with infection. The purpose of this study was to obtain an objective overview of Ampicillin Sulbactam resistance patterns of culture in patients hospitalized in pediatric Hemato-Oncology Ward, Dr Soetomo Hospital, Surabaya. This was a descriptive study. Data on culture and susceptibility test result to Ampicillin Sulbactam were taken from medical records of those patients between September 2012 - February 2013. There were 342 culture examinations in 88 patients (44 girls and 44 boys). Most of the children aged <5 years (58%). Growth of bacterial cultures was obtained in 83 namely Escherichia coli, Burkholderia cepacia, and Klebsiella oxytoca (Gram-negative) and coagulation negative Staphylococcus (CONS), Staphylococcus aureus, and Staphylococcus saprophyticus (Gram-positive) were found in blood culture. Staphylococcus aureus (Gram positive) and E. coli, Klebsiella pneumoniae, and B.cepacia (Gram-negatif) were found in urine. The result of antibiotic susceptibility test culture showed resistance to Ampicillin Sulbactam in E. coli (69%), Burkholderia cepacia (85%), CONS (50%), Staphylococcus aureus (25%), K. pneumoniae (85%), Klebsiella oxytoca (50%), and P. aeroginosa (67%). There was ampicillin sulbactam resistance in children hospitalized in pediatric Hemato-Oncology Ward, Dr Soetomo Hospital, Surabaya against E. coli (69%), Burkholderia cepacia (85%), CONS (50%), Staphylococcus aureus (25%), K.pneumoniae (85%), and Klebsiella oxytoca (50%), P. aeroginosa (67%).
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Copyright (c) 2016 Oka Putrawan, IGAA Putri Sri Rejeki
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References
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References
Danai PA, Moss M, Mannino DM, Martin GS (2006). The epidemiology of sepsis in patients with malignancy. Chest 129, 1432-1440
Del Favero A, Bucaneve G, Furno P (2004). Choice of empirical therapy and prophylaxis. Hematol J 5 Suppl 3, S53-58
Patrick CC (2001). Clinical Management of Infections in Immunocompromised Infants and Children, 1st ed., Philadelphia, Lippincott Williams & Wilkins, p 584-615
Ranuhardy D, Kurnianda J, Abdulmuthalib, Atma-kusuma D, Kar AS, Acang N, Mediarty, Fadjari H, Tobing ML, Ashariati A, Fakhruddin, Darmayuda TG, Darmawan B, Harryanto A (2006). Panduan Tatalaksana Febril Neutropeni/Demam Neutropeni pada Pasien Kanker, Jakarta, Balai Penerbit Fakultas Kedokteran Universitas Indonesia, p 1-14
Tiflah, Farida H (2006). Bakteremia pada Neonatus: Hubungan Pola Kuman dan Kepekaannya terhadap Antibiotik Inisial serta Faktor Risikonya di Bangsal Bayi Risiko Tinggi (BBRT) RS Dr Kariadi Semarang Tahun 2004. Thesis. Universitas Diponegoro, Indonesia
Toltzis P, Yamashita T, Vilt L, Blumer JL (1997). Colonization with antibiotic-resistant gram-negative organisms in a pediatric intensive care unit. Crit Care Med 25, 538-544
Waterer GW, Wunderink RG (2001). Increasing threat of Gram-negative bacteria. Crit Care Med 29, N75-81