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Submitted
21 August 2021
Accepted
28 June 2022
Published
5 December 2022
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Abstract

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  1. Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015.

  2. Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria.


 


Abstract:


Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosis (MDR-TB), while 1,860 people were confirmed patients with MDR-TB. There is a need for innovation to develop the latest treatments using natural ingredients, one of which is castor plant (Ricinus communis L.) that contains antibacterial compounds against Mycobacterium tuberculosis. This study aimed to understand the antimicrobial potential of castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis. This scientific paper was a quantitative systematic review study. Literature in the form of journal articles and books were obtained through search engines, i.e. ebook database, Google Scholar, Cochrane, Wiley, and PubMed. The results of the literature source search were 19 journal articles and 4 ebooks, as well as 4 journal articles that were in accordance with the title of this literature review and discussed the effects of castor plants on the growth of Mycobacterium tuberculosis. The results of the analysis showed that castor plant (Ricinus communis L.) leaf extract has the potential in the antibacterial activity against the growth of Mycobacterium tuberculosis because it contains phytochemicals in the form of flavonoids, saponins, alkaloids, tannins, and fatty acid amides derived from ricinoleic acid as the main constituent of castor plants (Ricinus communis L.). There is antimicrobial potential for castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis.

Keywords

Castor plant leaf minimal inhibitory levels Ricinus communis L. lung health Mycobacterium tuberculosis tuberculosis

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How to Cite
Istaufa, F. S., Subagio, Y., Suswati, I., & Isbandiyah. (2022). Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis. Folia Medica Indonesiana, 58(4), 371–376. https://doi.org/10.20473/fmi.v58i4.29307
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References

  1. Aljanaby AAJ, Al-Faham QMH, Aljanaby IAJ, et al (2022). Epidemiological study of Mycobacterium tuberculosis in Baghdad Governorate, Iraq. Gene Reports 26, 101467.
  2. Arya V (2011). A review on anti-tubercular plants. Int J PharmTech Res 3, 872–80.
  3. Azmy N (2020). Ricinus communis L. leaf extract as natural antimicrobial: Development of new antimicrobial against MDR microbes. Med Prof J Lampung 10, 443–7.
  4. Barbier M, Wirth T (2016). The evolutionary history, demography, and spread of the Mycobacterium tuberculosis complex ed. Jacobs Jr. WR, McShane H, Mizrahi V & Orme IM. Microbiol Spectr; DOI: 10.1128/microbiolspec.TBTB2-0008-2016.
  5. Collins L, Franzblau SG (1997). Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob Agents Chemother 41, 1004–9.
  6. Copp BR (2003). Antimycobacterial natural products. Nat Prod Rep 20, 535.
  7. D’Oca CDRM, Coelho T, Marinho TG, et al (2010). Synthesis and antituberculosis activity of new fatty acid amides. Bioorg Med Chem Lett 20, 5255–7.
  8. Drapal M, Fraser PD (2019). Metabolite profiling: A tool for the biochemical characterisation of Mycobacterium sp. Microorganisms 7, 148.
  9. Ekawati E (2018). Bacteriology: Microorganisms cause infection. Deepublish, Yogyakarta.
  10. Esteban J, García-Coca M (2018). Mycobacterium biofilms. Front Microbiol.
  11. García MT, Carreño D, Tirado-Vélez JM, et al (2018). Boldine-derived alkaloids inhibit the activity of DNA topoisomerase I and the growth of Mycobacterium tuberculosis. Front Microbiol.
  12. Ghramh HA, Khan KA, Ibrahim EH, et al (2019). Synthesis of gold nanoparticles (AuNPs) using Ricinus communis leaf ethanol extract, their characterization, and biological applications. Nanomaterials 9, 765.
  13. Gopalaswamy R, Shanmugam S, Mondal R, et al (2020). Of tuberculosis and non-tuberculous mycobacterial infections – A comparative analysis of epidemiology, diagnosis and treatment. J Biomed Sci 27, 74.
  14. Górniak I, Bartoszewski R, Króliczewski J (2019). Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem Rev 18, 241–72.
  15. Gupta RS, Lo B, Son J (2018). Phylogenomics and comparative genomic studies robustly support division of the genus Mycobacterium into an emended genus Mycobacterium and four novel genera. Front Microbiol.
  16. Houben RMGJ, Dodd PJ (2016). The global burden of latent tuberculosis infection: A re-estimation using mathematical modelling ed. Metcalfe JZ. PLOS Med 13, e1002152.
  17. Indonesian Ministry of Health (2016). Tuberkulosis, Temukan, Obati sampai Sembuh.
  18. Indonesian Ministry of Health (2018). Info Datin: Tuberculosis. Data Inf Cent.
  19. Kesumasar N, Napitupulu M, Jura M (2018). Analysis of flavonoid levels in Jatropha curcas L., Jatropha gossypifolia L., and Ricinus communis L. stems. J Acad Chem 7, 28–31.
  20. Kumar M (2017). A review on phytochemical constituents and pharmacological activities of Ricinus communis L. plant. Int J Pharmacogn Phytochem Res 9, 466–72.
  21. Ladda P, Magdum C (2012). Evaluation of anti-tubercular activity of Ricinus communis Linn. by proportion, NRA and bact/alert methods. Int J Pharm Pharm Sci 4, 474–8.
  22. Ladda P, Magdum C, Naikwade N (2018). Isolation, Characterization of Bioactive Compounds and Evaluation of Anti-Tubercular Activity of Ricinus communis Linn. Int J Pharm Sci Rev Res 51, 41–7.
  23. Lyon SM, Rossman MD (2017). Pulmonary tuberculosis ed. Schlossberg D. Microbiol Spectr.
  24. MacNeil A, Glaziou P, Sismanidis C, et al (2020). Global epidemiology of tuberculosis and progress toward meeting global targets — Worldwide, 2018. MMWR Morb Mortal Wkly Rep 69, 281–5.
  25. Maisetta G, Batoni G, Caboni P, et al (2019). Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus. BMC Complement Altern Med 19, 82.
  26. Manson AL, Cohen KA, Abeel T, et al (2017). Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. Nat Genet 49, 395–402.
  27. Mertaniasih N (2019). Microbiological diagnostic tuberculosis textbook. Airlangga University Press, Surabaya.
  28. Okunade AL, Elvin-Lewis MP, Lewis WH (2004). Natural antimycobacterial metabolites: Current status. Phytochemistry 65, 1017–32.
  29. Pfyffer GE (2015). Mycobacterium: General characteristics, laboratory detection, and staining procedures. In Manual of Clinical Microbiology, pp. 536–69. ASM Press, Washington, DC, USA.
  30. Rabahi MF, Silva Júnior JLR da, Ferreira ACG, et al (2017). Tuberculosis treatment. J Bras Pneumol 43, 472–86.
  31. Rashid S, Ahmad M, Zafar M, et al (2015). Ethnobotanical survey of medicinally important shrubs and trees of Himalayan region of Azad Jammu and Kashmir, Pakistan. J Ethnopharmacol 166, 340–51.
  32. Suurbaar J, Mosobil R, Donkor A-M (2017). Antibacterial and antifungal activities and phytochemical profile of leaf extract from different extractants of Ricinus communis against selected pathogens. BMC Res Notes 10, 660.
  33. Suvarna CM, Sriya P, Arshad M, et al (2018). A review on phytochemical and pharmacological properties of Ricinus communis. Int J Pharma Res Heal Sci 6, 2651–5.
  34. Ullah S, Hussain S, Khan SN, et al (2017). The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan. Int J Mycobacteriology 6, 102.
  35. Usmani SS, Kumar R, Kumar V, et al (2018). AntiTbPdb: A knowledgebase of anti-tubercular peptides. Database.
  36. Velayati AA, Farnia P (2016). Atlas of Mycobacterium tuberculosis. Academic Press Elsevier, Iran.
  37. World Health Organization (2015). Global tuberculosis report 2015, 20th ed.