Pudji Lestari, Ivan Rahmatullah, Dwi Susanti

Abstract views = 635 times | downloads = 758 times


Tuberculosis developed differently in each individual. The role of HIV in the disease development is widely known unlike the role of Hepatitis B and Hepatitis C infection. Therefore, this study is aimed at to describe the role of those co-infections in the TB development. The study employed observational – case control design with two groups, case and control group. Data collection include TB condition, whether latent or manifest, and history of Hepatitis B and Hepatitis C co-infection. The study successfully recruited the total of 32 respondents in each group. At the case group, the number of male and respondent is 19 and 13. Meanwhile, at the control group the number male respondent is 10 and the female respondent is 22. The study found that 20 and 12 respondents were positive Hepatitis B at the case and the control group. Chi-square test resulted significant different between two groups (P=0.0455 and a =0.05) with odd ratio p=0.479. Meanwhile, the study only tested one respondent with positive Hepatitis C at case group and one at control group. Comparison analysis found no significant different between groups (P=1 and a =0.05). This study reveals that TB patients are more likely to have history of Hepatitis B 2.7 times than those at the control group with the same infection but without TB development. Therefore, the possibility of Hepatitis B co-infection has role in the TB manifestation, but not for Hepatitis C co-infection.


hepatitis B, hepatitis C, coinfection, tuberculosis

Full Text:



Graubard SYH, Chen F, Barrett CJ, Qiao YL, Forman MR (2011). Tuberculosis and oncogenic HPV: potential co-infections in women at high-risk of cervical cancer in rural China. Asian Pacific Journal of Cancer Prevention 12, 1409-1415

Lestari P, Sustini F, Endaryanto A, Asih R (2011). Home humidity increased risk of tuberculosis in children living with adult active tuberculosis cases. Universa medicina 30, 138-145

Ministry of Health Republic of Indonesia (2010). Report on Result of National Basic Health Research (RISKESDAS 2010), Jakarta, Departemen Kesehatan Republik Indonesia

Mo P, Zhu Q, Teter C, Yang R, Den L, Yan Y, Chen J, Zeng J, ui XE (2014). Prevalence, drug-induced hepatotoxicity, and mortality among patients multi-infected with HIV, tuberculosis, and hepatitis virus. Int J Infect Dis 28, 95-100

Nagelkerke N (2012). Courtesans and consumption, how sexually transmitted infection drive tuberkulosis epidemics. Eburon, Delft Netherlands.

Pustylnikov S, Sagar D, Jain P, Khan Z (2014). Targeting the C-type lectins-mediated host-pathogen interaction with dextran. J Pharm Pharm Sci 17, 371-392

Setiawati L, Endaryanto A, Kusumadewi A, Lestari P (2011). Effect of BCG vaccination and non-tuberculous mycrobacterium infection on interferon gamma specific assay and a tuberculin ski test amonf children with a tuberculosis contact in Surabaya, Indonesia. Southeast Asian J Trop Med Public Health 42, 1460-1468

Soemantri S, Senewe FP, Tjandrarini DH, Day R, Basri C, Manissero D, Mehta F, Dye C (2007). Three-fold reduction in the prevalence of tuberculosis over 25 years in Indonesia. The International Journal of Tuberculosis and Lung Disease 11, 398-404

WHO (2013). TB country profile 2013. Available from Accessed November 2, 2013

Zhang L, Zhang D, Chen W, Zou X, Ling L (2013). High prevalence of HIV, HCV and tuberkulosis and associated risk behaviours among new entrants of methadone maintenance treatment clinics in Guangdong Province, China. PLoS One 8, e76931


  • There are currently no refbacks.

Copyright (c) 2017 Pudji Lestari, Ivan Rahmatullah, Dwi Susanti

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Indexed By

View My Stats

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.