Article Sidebar

Submitted
2 September 2024
Accepted
10 December 2024
Published
11 December 2024
Download
PDF
Statistic
Read Counter : 57 Download : 6

Main Article Content

Abstract

Colorectal cancer patients generally undergo laparotomy as part of the management. The earliest complications of laparotomy are bleeding, surgical wound infection, and anastomotic dehiscence. Albumin-lymphocytes are indicators of nutritional status and inflammation combined in the Prognostic Nutritional Index (PNI). Evaluation of PNI related to the degree of post-laparotomy wounds in colorectal cancer has not been widely explained. Objective: to find out the correlation of PNI for laparotomy wound complications in colorectal cancer patients at Dr. Zainoel Abidin General Hospital Banda Aceh. Method: A cross-sectional study will assess the correlation of PNI to the degree of post-operative wounds with the South Hampton Wound Scale. PNI values were determined by albumin and lymphocytes. The subjects were colorectal cancer patients, aged 18 years and underwent laparotomy. The assessment was carried out on the 7th day after laparotomy. The Spearman test was performed to determine the correlation. Results: 30 colorectal cancer patients as samples, with an average age of 49.43 years old (±11.06), male (56.7%), moderately differentiated adenocarcinoma (46.7%), average albumin 3.08 (±0.47) and lymphocytes 13.93 (±8.22). After evaluation, we found that patients with normal PNI values ​​had South Hampton grade 1 (23.3%), while mild malnutrition was in grade 1 (6.7%) and 2 (6.7%), moderate malnutrition was in grade 3 (23.3%) and grade 4 (16.7%) and severe malnutrition were in grade 4 (16.7%) and grade 5 (13.3%). Conclusion: There was a very strong correlation between PNI and postoperative wound complications in colorectal cancer.

Keywords

Prognostic Nutritional Index South Hampton wound scale colorectal cancer laparotomy

Article Details

License

Copyright (c) 2024 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Amirul Hadi, Muhammad Yusuf, Iflan Naufal, Muslim, & Imam Hidayat. (2024). Prognostic Nutritional Index with Wound Complication After Laparotomy in Colorectal Cancer Patients at Dr. Zainoel Abidin General Hospital Banda Aceh. Folia Medica Indonesiana, 60(4), 288–297. https://doi.org/10.20473/fmi.v60i4.62693
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray, F. Global patterns and trends in colorectal cancer incidence and mortality. Gut 66, 683-691 (2017).
  2. Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians 71, 209-249 (2021).
  3. Chiu, H.-M., Hsu, W.-F., Chang, L.-C. & Wu, M.-H. Colorectal cancer screening in Asia. Current gastroenterology reports 19, 1-8 (2017).
  4. Ferlay, J. et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European journal of cancer 49, 1374-1403 (2013).
  5. Indonesia, P. D. S. B. D., Indonesia, P. D. S. O. R., Indonesia, I. A. P. A., Fisik, P. D. S. K. & Indonesia, R. Pedoman Nasional Pelayanan Kedokteran Kolorektal (2016).
  6. Debas, H. T. Small and large intestine. Gastrointestinal Surgery: Pathophysiology and Management, 239-310 (2011).
  7. Ge, X. et al. Early Postoperative Decrease of Serum Albumin Predicts Surgical Outcome in Patients Undergoing Colorectal Resection. Diseases of the Colon & Rectum 60, 326-334 (2017). https://doi.org:10.1097/dcr.0000000000000750
  8. Schmoll, H. et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision-making. Annals of oncology 23, 2479-2516 (2012).
  9. Keung, E. Z. & Raut, C. P. Management of gastrointestinal stromal tumors. Surgical Clinics 97, 437-452 (2017).
  10. Sastroasmoro, S. & Ismael, S. Studi cross-sectional. Dasar-dasar metodologi penelitian klinis (2008).
  11. Baidoun, F. et al. Colorectal cancer epidemiology: recent trends and impact on outcomes. Current drug targets 22, 998-1009 (2021).
  12. Venugopal, A. & Carethers, J. M. Epidemiology and biology of early onset colorectal cancer. EXCLI journal 21, 162 (2022).
  13. Truong, A., Hanna, M. H., Moghadamyeghaneh, Z. & Stamos, M. J. Implications of preoperative hypoalbuminemia in colorectal surgery. World J Gastrointest Surg 8, 353-362 (2016). https://doi.org:10.4240/wjgs.v8.i5.353
  14. Chiang, J. M. et al. Pre-operative serum albumin level substantially predicts post-operative morbidity and mortality among patients with colorectal cancer who undergo elective colectomy. European Journal of Cancer Care 26, e12403 (2017). https://doi.org:https://doi.org/10.1111/ecc.12403
  15. Wierdak, M. et al. Changes in plasma albumin levels in early detection of infectious complications after laparoscopic colorectal cancer surgery with ERAS protocol. Surgical Endoscopy 32, 3225-3233 (2018). https://doi.org:10.1007/s00464-018-6040-4
  16. Iseki, Y. et al. The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer. Surgery Today 47, 743-754 (2017). https://doi.org:10.1007/s00595-016-1433-2
  17. Yamamoto, M. et al. Combined Pre- and Postoperative Lymphocyte Count Accurately Predicts Outcomes of Patients with Colorectal Cancer. Digestive Surgery 36, 487-494 (2018). https://doi.org:10.1159/000492340
  18. Mohri, Y., Inoue, Y., Tanaka, K., Hiro, J., Uchida, K. & Kusunoki, M. Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer. World Journal of Surgery 37, 1 (2013). https://doi.org:https://doi.org/10.1007/s00268-013-2156-9
  19. Sun, G. et al. Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis. International journal of colorectal disease 34, 681-689 (2019).
  20. Bailon-Cuadrado, M. et al. Prognostic nutritional index predicts morbidity after curative surgery for colorectal cancer. Cirugía Española (English Edition) 97, 71-80 (2019).
  21. Mohri, Y., Inoue, Y., Tanaka, K., Hiro, J., Uchida, K. & Kusunoki, M. Prognostic nutritional index predicts postoperative outcome in colorectal cancer. World journal of surgery 37, 2688-2692 (2013).