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Submitted
25 October 2024
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3 June 2025
Published
3 June 2025
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Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin's potential as a therapeutic agent for UV-B-induced skin damage.

Keywords

astaxanthin UV-B TNF-α IL-10

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Author Biography

Nur Lailatul Fadhilah, Gynaecologic Obstetric Staff, Semen Gresik Hospital, Gresik

Gynaecologic Obstetric Staff, Semen Gresik Hospital, Gresik 61122, Indonesia

How to Cite
Akhmad Setyo Rahman, Theresia Indah Budhy, Jusak Nugraha, & Nur Lailatul Fadhilah. (2025). THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-α) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL. Folia Medica Indonesiana, 61(1). Retrieved from https://e-journal.unair.ac.id/FMI/article/view/64529
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