Main Article Content

Abstract

Premature labor is a cause of high rates of perinatal morbidity and mortality. The use of tocolytics is one of the efforts to handle the risk of preterm labor. Tocolytics which are widely used in Indonesia is isoxsuprine and nifedipine. The purpose of this study was to identify the difference of effectiveness and safety of isoxsuprine as tocolytics in the risk of preterm labor. This was an observational study in the form of a case study that was done in detail and depth to the patients who were diagnosed as imminent preterm labor. In conclusion, there were differences in the effectiveness and safety of isoxsuprine and nifedipine as tocolytics in the risk of preterm labor.

Keywords

The risk of preterm labor effectiveness safety tocolytics

Article Details

How to Cite
Oktavia, N., Yulistiani, Y., Markus, U. H., & Mamo, H. I. (2017). EFFECTIVENESS AND SAFETY DIFFERENCES OF ISOXSUPRINE AND NIFEDIPINE AS TOCOLYTICS IN THE RISK OF PRETERM LABOR. Folia Medica Indonesiana, 53(4), 242–246. https://doi.org/10.20473/fmi.v53i4.7153

References

  1. Agudelo AC, Romero R, Kusnovic JP (2011). Nifedipin in the management of preterm labor: a systematic review and metaanalysis. American Journal of Obste-trics & Gynecology 204, p134.e1-20
  2. Blencowe H, Cousens S, Chou D, et al (2013). Born too soon: the global epidemiology of 15 million preterm births. Reproductive Health 10, S2
  3. Haas DM, Caldwell DM, Kirkpatrick PR, McIntosh JJ, Welton NJ (2012). Tocolytic therapy for preterm deli-very: systematic review and network meta-analysis. British Medical Journal 345, e6226
  4. Jusuf J (2008). Efektivitas dan efek samping ketorolac sebagai tokolitik pada ancaman persalinan prematur, tinjauan perbandingan dengan nifedipin. Semarang, Universitas Dipenogoro
  5. POGI (2011). Panduan pengelolaan persalinan preterm nasional. Bandung, Himpunan Kedokteran Fetoma-ternal POGI
  6. Pradyuman V, Mekhla G (2014). a comparative study of two tocolytic agents for inhibition of preterm labour. Gujarat Medical Jurnal 69
  7. Simhan HN, Caritis SN (2007). Prevention of preterm delivery. The New England Journal of Medicine 357, 477-87
  8. Sudoyo AW (2009). Buku ajar penyakit ilmu dalam. 5th ed. Jakarta, Interna Publishing
  9. Suspimantari C (2014). Faktor-faktor resiko prema-turitas yang berpengaruh terhadap luaran maternal dan perinatal berdasarkan usia kehamilan. Semarang, Universitas Dipenogoro
  10. RCOG (2011). Tocolysis for women in preterm labour. Green-top Guidline No. 1b. Royal College of Obste-tricians and Gynaecologist. February
  11. van Geijn HP, Lenglet JE, Bolte AC (2005). Nifedipine trials: effectiveness and safety aspects. BJOG: an In-ternational Journal of Obstetrics & Gynaecology 112, 79-83
  12. Yamasato K, Burlingame J, Kaneshiro Bliss (2015). Hemodynamic effects of nifedipin tocolysis. The Jour-nal of Obstetrics and Gynaecology Research 41, 17-22
  13. Yogol NS, Shakya R, Thapa P (2009). Ritodrine and isoxsuprine in management of preterm labor. Journal of Nepal Medical Association 48, 265-8