PENGARUH EXERCISE INTENSITAS TINGGI TERHADAP KETEBALAN ENDOMETRIUM MENCIT (MUS MUSCULUS)
Downloads
Abstrak
Latar Belakang : Exercise dapat menyebabkan terbentuknya reactive oxygen species (ROS). Ketidakseimbangan antara antioksidan endogen dan ROS dapat menyebabkan stres oksidatif. Stres oksidatif dapat menyebabkan infertilitas pada wanita melalui berbagai mekanisme. Endometrium yang tidak sempurna karena ROS tidak dapat mendukung embrio dan perkembangannya. Penelitian ini bertujuan untuk menganalisa perbedaan ketebalan endometrium pada mencit yang exercise intensitas tinggi. Metode : Penelitian ini true experimental dengan rancangan randomized posttest only design. Besar sampel adalah 7 ekor tiap kelompok, yang terdiri dari 2 kelompok. Kelompok kontrol dan kelompok exercise intensitas tinggi. Data yang didapatkan adalah ketebalan endometrium mencit. Hasil : hasil uji mann-whitney menunjukkan hasil yang signifikan dengan P=0,006. Kesimpulan : exercise intensitas tinggi dapat mempengaruhi ketebalan endometrium..
Abstract
Background: Reactive Oxygen Species (ROS) is formed by exercise. Oxidative stress is caused by an imbalance between endogenous antioxidants and ROS. Oxidative stress causes infertility in women through mechanisms. Because of ROS, endometrium can not support the embryo and its development. This research aim to analyze different of endometrial thickness mice with high intensity exercise. Methods: This research is true experimental researh with randomized posttest only design. The sample size is 7 female mice each group, devided into 2 groups. The control group, and the high-intensity exercise group. Data obtained from mice endometrial thickness Results: mann-whitney gave significant result at level p=0.006. Conclusion: high intensity exercise can effect the thickness of the endometrium.
Agarwal, A. et al. (2005) Role of oxidative stress in female reproduction, Reproductive Biology and Endocrinology, 3(1), p. 28. Diperoleh dari: http://rbej.biomedcentral.com/articles/10.1186/1477-7827-3-28 (diakses pada 28 Oktober 2018)
Ahrens, K. A. et al. (2014) The effect of physical activity across the menstrual cycle on reproductive function, Annals of Epidemiology. Elsevier Inc, 24(2), pp. 127–134. Diperoleh dari : doi: 10.1016/j.annepidem.2013.11.002.
Fawcett, Don (2002) Buku Ajar Histologi. Jakarta : EGC, pp. 60-71
Function, S. et al. (2005) Review Oxidative stress and its implications in female infertility – a clinician ' s perspective, 11(5), pp. 641–650.
Gupta, S. et al. (2008) The Impact of Oxidative Stress on Female Reproduction and ART: An Evidence-Based Review, in Rizk, B. R. M. B. et al. (eds) Infertility and Assisted Reproduction. Cambridge: Cambridge University Press, pp. 629–642.Diperoleh dari: doi: 10.1017/CBO9780511547287.067.
Holsgaard, A. and Roos, E. M. (2012) Effects of physical exercise on female reproductive system, 48(4), pp. 577–585.
Meczekalski, B. et al. (2014) Functional hypothalamic amenorrhea and its influence on women's health, Journal of Endocrinological Investigation, 37(11), pp. 1049–1056. Diperoleh dari: doi: 10.1007/s40618-014-0169-3.
Speroff, L. and Fritz, M. (2011) Clinical Endocrinology and Infertility, Lippincott Williams & Wilkins. Diperoleh dari: doi: 10.4183/aeb.2005.240.
Sylviana, N. et al. (2017) The Effect of Astaxanthin and Regular Training on Dynamic Pattern of Oxidative Stress on Male under Strenuous Exercise, IOP Conference Series: Materials Science and Engineering, 180(1), p. 012173. Diperoleh dari : doi: 10.1088/1757-899X/180/1/012173.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The formal legal aspect of journal publication accessibility refers to Creative Commons Atribution-Share Alike 4.0 (CC BY-SA).
This Journal (e-ISSN 2656-7806) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
