BINAHONG [Anredera cordifolia (Tenore) Steenis] LEAF INFUSA FOR SUTURE WOUND INFECTION CONVALESCENCE
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Background: Postpartum infections are the top 4 main causes of the high maternal mortality rate in Indonesia at 2022 of 183 per 100,000 live births. Efforts to prevent complications due to infection of puerperal suture wounds with pharmacological therapy using antibiotics and antiseptics, as well as non-pharmacological ones using plant extracts. Binahong is believed to contain flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids, which are especially useful in healing wound infections. The aim of the study was to determine the effectiveness of infusion of binahong leaves (Anredera cordifolia (Tenore) Steenis) on the healing of suture wound infections in rats (Rattus norvegicus) experimental animals. Method: The research method was a true-experimental posttest only control group design, the study was conducted from June to August 2023 at the Microbiology and Pharmacology Laboratory of Muhammadiyah Sidoarjo University, the research variables were binahong leaf infusion and healing of suture infection, assessment and data collection using the REEDA scale instrument, statistical analysis with the one-way ANOVA, and post-hoc follow-up tests. Result: The results showed p <0.05, so there was a significant effect of giving binahong leaf infusion on the healing of suture wound infections. In terms of the difference in the mean value and the results of the post-hoc significant difference test, it appears that the 5% binahong leaf infusion group showed the most effective results in healing suture wound infections and was significantly different from the negative control group with less effective healing of suture infections. Conclusion : This is in line with research that states that the group given a 5% concentration of binahong extract was more effective than the group with a higher concentration. Thus, administration of a 5% concentration of binahong leaf infusion can be an alternative for healing suture wound infections due to the important content in it in the form of flavonoids, terpenoids, saponins, tannins, essential oils, and alkaloids. Further research is needed with lower concentrations of binahong leaf infusion to find out the minimum concentration that can have a good effect on the convalescence of suture wound infections.
Barku, V. Y. A., Boye, A., & Ayaba, and S. (2015). (PDF) Phytochemical screening and assessment of wound healing activity of the leaves of Anogeissus leiocarpus. https://www.researchgate.net/publication/256077800_Phytochemical_screening_and_assessment_of_wound_healing_activity_of_the_leaves_of_Anogeissus_leiocarpus
BPOM. (2016). Binahong binahong binahong. BPOM.
Dinas Kesehatan Provinsi Jawa Timur. (2021). Profil Kesehatan Dinas Kesehatan Provinsi Jawa Timur 2021. Dinas Kesehatan Provinsi Jawa Timur, tabel 53.
Dinkes Sidoarjo, Profil Kesehatan Kabupaten Sidoarjo Tahun 2021. (2022). DINKES SIDOARJO. http://dinkes.sidoarjokab.go.id/2022/06/03/profil-kesehatan-kabupaten-sidoarjo-tahun-2021/
Gurcharan Singh, G. K. a/p, Utami, N. V., & Usman, H. A. (2014). Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice. Althea Medical Journal, 1(1), 6–11. https://doi.org/10.15850/amj.v1n1.289
Gusnimar, R., Veri, N., & Mutiah, C. (2021). Pengaruh Air Rebusan Daun Binahong Dalam Mempercepat Penyembuhan Luka Perineum Masa Nifas. Sel Jurnal Penelitian Kesehatan, 8(1), 15–23. https://doi.org/10.22435/sel.v8i1.4521
Hamilton, S. M., Stevens, D. L., & Bryant, A. E. (2013). Pregnancy-related group a streptococcal infections: temporal relationships between bacterial acquisition, infection onset, clinical findings, and outcome. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 57(6), 870–876. https://doi.org/10.1093/CID/CIT282
Handajani, F. (2021). Metode Pemilihan dan pemnbuatan hewan model beberapa penyakit pada penelitian eksperimental.
Hasyim, M. F. (2020). Uji Efektivitas Anti Bakteri Infusa Umbi Binahong (Anredera cordifilia (Ten) steenis) Terhadap Pertumbuhan Escherichia coli. Jurnal Farmasi Sandi Karsa, 6(2), 69–72. https://doi.org/10.36060/jfs.v6i2.72
Kemenkes, R. (2021). Pedoman Penggunaan Antibiotik. Pedoman Penggunaan Antibiotik, 1–97.
Kurniawan, B. dan, & Aryana, W. (2017). Binahong (Cassia Alata L.) For Inhibiting The Growth of Bacteria Escherichia coli. J Majority, 4(4), 100–104.
Lestari, D., Sukandar, E. Y., & Fidrianny, I. (2016). Anredera cordifolia leaves fraction as an antihyperlipidemia. Asian Journal of Pharmaceutical and Clinical Research, 9(6), 82–84. https://doi.org/10.22159/ajpcr.2016.v9i6.13628
Lubis, D. H. (2016). View of PENGETAHUAN IBU HAMIL TENTANG INFEKSI MASA NIFAS DI DESA TANDAM HILIR II KECAMATAN HAMPARAN PERAK KABUPATEN DELI SERDANG. Jurnal Kebidanan Flora. https://www.jurnal.stikesflora-medan.ac.id/index.php/jkbf/article/view/207/204
Miladiyah, I., & Prabowo, B. R. (2012). Ethanolic extract of Anredera cordifolia (Ten.) Steenis leaves improved wound healing in guinea pigs. Universa Medicina, 31(1), 4–11. https://univmed.org/ejurnal/index.php/medicina/article/view/107
Misaco Yuniarti, W., & Sektiari Lukiswanto, B. (2017). Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats. https://doi.org/10.14202/vetworld.2017.808-813
Nurhidayanti. (2019). View of PEMANFAATAN DARAH SISA TRANSFUSI DALAM PEMBUATAN MEDIA BAP UNTUK PERTUMBUHAN BAKTERI Streptococcus pyogenes. https://jurnal.univpgri-palembang.ac.id/index.php/biosains/article/view/3189/3001
Phillips, C., & Walsh, E. (2020). Group A Streptococcal Infection During Pregnancy and the Postpartum Period. Nursing for Women's Health, 24(1), 13–23. https://doi.org/10.1016/j.nwh.2019.11.006
Postol, E., Alencar, R., Higa, F. T., Freschi de Barros, S., Demarchi, L. M. F., Kalil, J., & Guilherme, L. (2013). StreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred Mice. PLoS ONE, 8(4), 60969. https://doi.org/10.1371/JOURNAL.PONE.0060969
Rejeki, P. S., Putri, E. A. C., & Prasetya, R. E. (2018). Ovariektomi Pada Tikus Dan Mencit. In Airlangga University Press.
Rosmania, R., & Yanti, F. (2020). Perhitungan jumlah bakteri di Laboratorium Mikrobiologi menggunakan pengembangan metode Spektrofotometri. Jurnal Penelitian Sains, 22(2), 76–86. https://doi.org/10.56064/jps.v22i2.564
Royal College of Obstetrician & Gynecologist. (2012). Bacterial Sepsis following Pregnancy. Green-to Guideline No 64B, 1, 1–21. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_64b.pdf
Sasidharan, S., Nilawatyi, R., Xavier, R., Latha, L. Y., & Amala, R. (2010). Wound healing potential of Elaeis guineensis Jacq leaves in an infected albino rat model. Molecules (Basel, Switzerland), 15(5), 3186–3199. https://doi.org/10.3390/MOLECULES15053186
Setyawan, R. (2015). Kadar Asam Urat pada Model Tikus Hiperurisemia Setelah Pemberian Infusa Daun Sirsak (Anona muricata L.). 1–13. https://repository.unej.ac.id/handle/123456789/68473
Shinar, S., Fouks, Y., Amit, S., Pauzner, D., Tarabeia, J., Schechner, V., & Many, A. (2016). Clinical Characteristics of and Preventative Strategies for Peripartum Group A Streptococcal Infections. Obstetrics and Gynecology, 127(2), 227–232. https://doi.org/10.1097/AOG.0000000000001238
Sukandar, E. Y., Kurniati, N. F., & Fitria, V. I. A. (2014). Innovare Academic Sciences EVALUATION OF TERATOGENICITY EFFECTS OF ETHANOLIC EXTRACTS OF BINAHONG LEAVES ( ANREDERA CORDIFOLIA ( TEN ) STEENIS ) IN WISTAR RAT. 6(11), 2–6. https://www.researchgate.net/profile/Elin-Sukandar/publication/271854663_Evaluation_of_teratogenicity_effects_of_ethanolic_extracts_of_binahong_leaves_anredera_cordifolia_ten_steenis_in_wistar_rat/links/54d5a9aa0cf2970e4e6550d7/Evaluation-of-teratogenicit
Violante, I. M. P., Carollo, C. A., Silva, L. I., Oliveira, A. Q. C., Pardinho, F. C., Garcez, W. S., Garcez, F. R., Oliveira, R. G. de, Arunachalam, K., & de Oliveira Martins, D. T. (2021). Cytotoxicity and antibacterial activity of scutellarein and carajurone-enriched fraction obtained from the hydroethanolic extract of the leaves of Fridericia chica (Bonpl.) L.G. Lohmann. Natural Product Research, 35(23), 5287–5293. https://doi.org/10.1080/14786419.2020.1753050
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