The Potential of Acetylfuran and Furfural from Tamarindus indica as Lipoxygenase Inhibitor: In Silico Study
Downloads
Background: Tamarindus indica is a type of plant sub-family Caesalpinioideae, which is predicted to have anti-inflammatory properties. When inflammation occurs, arachidonic acid will undergo metabolism, the LOX pathway will release 5-lipoxygenase (5-LOX). Objective: This study aimed to analyze the potential of acetylfuran and furfural compounds on LOX action. Methods: The compound Acetylfuran (CID 14505), Furfural (CID 7362) were downloaded from the PubChem database. The 5-LOX protein was obtained from PDB (6N2W), preparation by removing ligands and molecules that bind to Discovery Studio V19.1.0.18287. Compound and protein interactions have interacted with the Vina autodock software integrated into the PyRX software and analyzed by Discovery Studio V19.1.0.18287. Results: The results showed that the content of Acetylfuran and Furfural compounds in Tamarindus indica is predicted to have the potential as an inhibitor of the LOX gene on different amino acid residues, namely 3 amino acid residues and 4 amino acid residues, respectively and produce binding energy. In addition, van der Waals forces, hydrogen and hydrophobic bonds were found, giving the strength of the bonds formed. Conclusion: Bioactive acetylfuran and furfural have the potential as a drug to curve inflammation in the human body.
Abdulkhaleq, L. A., Assi, M. A., Abdullah, R., Zamri-Saad, M., Taufiq-Yap, Y. H. & Hezmee, M. N. M. (2018). The Crucial Roles of Inflammatory Mediators in Inflammation: a Review. Veterinary World; 11; 627–635.
Adeola, A. A., Adeola, O. O. & Dosumu, O. O. (2010). Comparative Analyses of Phytochemicals and Antimicrobial Properties of Extracts of Wild Tamarindus indica Pulps. African Journal of Microbiology Research; 4; 2769–2779.
Al-u'datt, D., Allen, B. G. & Nattel, S. (2019). Role of the Lysyl Oxidase Enzyme Family in Cardiac Function and Disease. Cardiovascular Research; 115; 1820–1837.
Andriyono, R. I. (2019). Kaempferia galanga L. sebagai Anti-Inflamasi dan Analgetik. Jurnal Kesehatan; 10; 495-503.
Bare, Y., Kuki, A. D., Rophi, A. H. & Candrakirana, G. (2019). Prediksi Asam Kuinat Sebagai Anti-Inflamasi Terhadap COX-2 Secara Virtual Virtual Prediction of Quinic Acid As Anti-Inflammation of COX-2. Biota: Jurnal Ilmu-Ilmu Hayati; 4; 124–129. https://doi.org/10.24002/biota.v4i3.2516
Bare, Y., Marhendra, A., Sasase, T. & Fatchiyah, F. (2018). Differential Expression of IL-10 Gene and Protein in Target Tissues of Rattus Norvegicus Strain Wistar Model Type 2 Diabetes Mellitus (T2DM). Acta Informatica Medica; 26; 87–92.
Bare, Y., Sari, D. R. T., Rachmad, Y. T., Krisnamurti, G. C. & Elizabeth, A. (2019). In Silico Insight the Prediction of Chlorogenic Acid in Coffee through Cyclooxygenase-2 (COX2) Interaction. Biogenesis: Jurnal Ilmiah Biologi; 7; 100–105.
Bhadoriya, S. S., Ganeshpurkar, A., Narwaria, J., Rai, G. & Jain, A. P. (2011). Tamarindus indica: Extent of Explored Potential. Pharmacognosy Review; 5; 73–81.
Bhadoriya, S. S. (2012). Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves. Scientia Pharmaceutica; 80; 685–700.
Borquaye, L. S., Doetse, M. S., Baah, S. O. & Mensah, J. A. (2020). Anti-Inflammatory and Anti-Oxidant Activities of Ethanolic Extracts of Tamarindus indica L. (Fabaceae). Cogent Chemistry; 6; 1-11.
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X. & Zhao, L. (2018). Inflammatory Responses and Inflammation-Associated Diseases in Organs. Oncotarget; 9; 7204–7218.
Komakech, R., Kim, Y., Matsabisa, G. M. & Kang, Y. (2019). Anti-Inflammatory and Analgesic Potential of Tamarindus indica Linn. (Fabaceae): a Narrative Review. Integrative Medicine Research; 8; 181–186.
Mayorca-Guiliani, A. & Erler, J. T. (2013). The Potential for Targeting Extracellular LOX Proteins in Human Malignancy. OncoTargets and Therapy; 6; 1729–1735.
Mueller, M., Hobiger, S. & Jungbauer, A. (2010). Anti-Inflammatory Activity of Extracts from Fruits, Herbs and Spices. Food Chemistry; 122; 987–996.
Putri, C. R. H. (2017). The Potency and Use of Tamarindus indica on Various Therapies. Jurnal Ilmiah Kedokteran Wijaya Kusuma; 3; 40-54.
Sari, D. R. T., Cairns, J. K., Safitri, A. & Fatchiyah, F. (2019). Virtual Prediction of the Delphinidin-3-O-Glucoside and Peonidin-3-O-glucoside as Anti-inflammatory of TNF-α Signaling. Acta Informatica Medica; 27; 152-157.
Tiring, S. S. N. D., Bare, Y., Maulidi, A., S, M. & Nugraha, F. A. D. (2019). Studi In Silico: Prediksi Potensi 6-shogaol dalam Zingiber Officinale sebagai Inhibitor JNK. Al-Kimia; 7; 147–153.
1. The copyright of this journal belongs to the Editorial Board and Journal Manager with the author's knowledge, while the moral right of the publication belong to the author.
2. The formal legal aspect of journal publication accessibility refers to the Creative Commons Attribution-Non-Commercial-Share Alike (CC BY-NC-SA), which implies that the publication can be used for non-commercial purposes in its original form.
3. Every publication (print/electronic) is open access for educational, research, and library purposes. In addition to the objectives mentioned above, the editorial board is not responsible for copyright infringement
.jpg)
