Formulation and Physical Evaluation of Kratom (Mitragyna speciosa Korth.) Leaf Extract Emulgel as an Analgesic in Mice (Mus musculus)
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Background: Kratom leaves contain major alkaloid compounds, particularly mitragynine and 7-hydroxymitragynine which have demonstrated anti-pain or analgesic properties. Objective: This study aims to evaluate the effectiveness of kratom leaf extract emulgel in reducing pain when applied topically in mice. Methods: This study was conducted on male mice that had been induced with acetan acid intraperitoneally. Following induction, emulgel formulations were applied topically and pain responses were recorded every five minutes over 30 minutes period. Group 1 (emulgel base without active ingredient), Group 2 (voltaren emulgel), Group 3 (emulgel with 5.6% extract concentration), Group 4 (emulgel with 11.6% extract concentration) and Group 5 (emulgel with 17.6% extract concentration). Results: The results of physical evaluations of emulgel formulations met the applicable standards. Observations of pain responses indicated optimal analgesic effect in the emulgels containing 11.6% and 17.6% extract concentration with analgesic values of 51.52% and 63.06% respectively. An active substance is considered to have analgesic activity whent it demonstrates ≥50% effectiveness. Conclusion: This study concluded that emulgels formulated with kratom leaf extract exhibited analgesic activity as evidenced by the decreased in the writhing response of mice every five minutes.
Anindita, P.R., Setyawati, H., Wahyuni, K.I., Putri, D.O. & Ambari. (2023). Uji Sediaan Krim Ekstrak Daun Kratom (Mitragyna Speciosa Korth.) yang Berpotensi sebagai Antinosiseptif pada Mencit Jantan Galur DDY. Jurnal Pharmascience; 10; 1-13. doi: org/10.20527/jps.v10i1.12146.
Bagiana, I.K. & Kresnawati, Y. (2020). Pengaruh Konsentrasi Campuran DMSO dan Olive Oil pada Jalur Transfor Natrium Diklofenak Melewati Kulit Secara In Vitro Menggunakan Pemodelan WimSAM. Laporan Kemajuan Penelitian. Sekolah Tinggi Ilmu Farmasi,Semarang.
Chandra, D. & Rahmah, R.. (2022). Uji Fisikokimia Sediaan Emulsi, Gel, Emulgel Ekstrak Etanol Goji Berry (Lycium barbarum L.). MEDFARM: Jurnal Farmasi dan Kesehatan; 11; 219–228. doi: org/10.48191/medfarm.v11i2.142.
Firmansyah., Temarwut, F.F., Topile, N.K. & Sudirman. (2023). Formulasi Dan Uji Efek Analgetik Emulgel Minyak Kayu Putih (Oleum melaleuca cajeputi) dengan Gelling Agent Carbopol 940. PAPS JOURNALS; 2; 75–84. doi: 10.51577/papsjournals.v2i2.467.
Kruegel, A. C., Uprety, R., Grinnell, S. G., Langreck, C., Pekarskaya, E. A., Le Rouzic, V., Ansonoff, M., Gassaway, M. M., Pintar, J. E., Pasternak, G. W., Javitch, J. A., Majumdar, S. & Sames, D. (2019). 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Central Science; 5; 992–1001. doi; 10.1021/acscentsci.9b00141.
Lara, A.D., Elisma. E. & Kusnadi, .F.S., (2021). Uji Aktivitas Analgesik Infusa Daun jeruju (Acanthus ilicifolius L.) Pada Mencit Putih Jantan (Mus musculus). Indonesian Journal of Pharma Science; 3; 71–80. doi: 10.22437/ijps.v3i2.15383.
Mutiara, S.N.I., Masriani., Muharini, R., Sapar, A. & Rasmawan, R. (2023). Comparison of Extraction Variations on Mitragynine Level of Three Variants of Kratom leaves (Mitragyna speciosa Korth). EduChemia (Jurnal Kimia dan Pendidikan); 8; 113–129. doi: 10.30870/educhemia.v8i1.21184.
Nugraha, W.I., Robiyanto, R. & Luliana, S. (2018). Aktivitas Antinosiseptif Fraksi Air Daun Kratom (Mitragyna speciosa Korth.) pada Mencit Jantan Swiss. Traditional Medicine Journal; 23; 91–96. doi: 10.24198/jf.v17i1.18839.
Patel, N., Chaudhary, S. & Chaudhary, A. (2022). Emulgel –Emerging as a Smarter Value-Added Product Line Extension for Topical Preparation. Indo Global Journal of Pharmaceutical Sciences; 12; 92–103. doi: 10.35652/IGJPS.2022.12008.
Rybarczyk, K.S. (2019). Quantitative Analysis of Mitragynine in Consumer Products Labeled as Kratom. Thesis. University of Illionis, Chicago.
Sofia, N., Yuniarti, Y. & Rosidah, R. (2022). Uji Fitokimia Terhadap Tanaman Obat Kratom (Mitragyna speciosa) di KHDTK ULM. Jurnal Sylva Scienteae; 5; 218–224. doi: 10.20527/jss.v5i2.5356.
Tamimi, A.A.., De Queljoe, E. & Siampa, J.P. (2020). Uji Efek Analgesik Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Pharmacon; 9; 325. h doi: 10.35799/pha.9.2020.30015.
Tiaravista, A.G., Robiyanto, R. & Luliana, S. (2019). Aktivitas Antinosiseptif Fraksi N-Heksan Daun Kratom (Mitragyna speciosa Korth.) Melalui Rute Oral pada Mencit Jantan Swiss. Farmaka; 17; 40–51. doi: 10.24198/jf.v17i1.18839.
Vanpariya, F., Shiroya, M. & Malaviya, M. (2021). Emulgel: A Review. International Journal of Science and Research (IJSR); 10; 847. doi: 10.21275/SR21311095015.
Voigt, R. (1994). Buku Pelajaran Teknologi Farmasi (Edisi V). Penerjemah : Soendari Noerono. Yogyakarta : Gajah Mada University Press.
Wahyono, S., Widowati, L., Handayani, L., Sampurno, O. D., Haryanti, S., Fauzi, F., Ratnawati, G. & Budiarti, M. (2019). Kratom: Prospek Kesehatan dan Sosial Ekonomi, Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehata (LBP).
Wang, K., LaBeff, L., Thomas, A. & Rouf, M. (2018). Topical Analgesics for Chronic Pain Conditions. Pract Pain Manag; 18; 5.
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