Literature Review: Relationship of Environmental Risk Factors and the Incidence of Leptospirosis in Settlements (2018–2023)
Introduction: Leptospirosis is zoonotic disease that transmits via natural transmission from vertebrate animals to human beings and vice versa. This disease is caused by an infection of the Leptospira sp. bacterium. It is estimated that there are 1 million cases of Leptospirosis that attack humans worldwide with 60 thousand deaths per year. In Indonesia, such cases and death rates have fluctuated. In 2021, there was a decrease in cases, but the CFR rate increased from 9.1% to 11.4%. Leptospirosis cases become endemic in many countries, especially in tropical and subtropical areas with high rainfall, especially in settlements with poor environmental conditions. Based on previous research, there were differences in the results between several research variables with the incidence of Leptospirosis. This gap underlies the writing of this article to bring together the existing results. Discussion: This study used literature review method for research articles on biotic and abiotic environmental risk factors with Leptospirosis in settlements sourced from scientific publication websites. After going through these stages, 14 final full text articles were obtained. The data used were research studies conducted from January 2018 to April 2023. The articles found show that environmental factors are closely related to the incidence of Leptospirosis in settlements. Conclusion: The variable abiotic environment factors associated with the occurrence of Leptospirosis are temperature, pH, the presence of sewers and puddles. The presence of rats and the presence of animals or livestock are related to biotic environmental factors.
Ministry of Health of the Republic Indonesia. Indonesia Health Profile 2021. Jakarta: Ministry of Health of the Republic Indonesia; 2022.
Widjajanti W. Epidemiologi, Diagnosis, dan Pencegahan Leptospirosis. JHECDs (Journal of Health Epidemiology Communicable Disease). 2019;5(2):62–68. https://dx.doi.org/10.22435/jhecds.v5i2.174
Sari IZR. Tinjauan Literatur : Leptospirosis di Indonesia. Majalah Kesehatan. 2021;8(2):113–121. https://dx.doi.org/10.21776/ub.majalahkesehatan.2021.008.02.7
Ministry of Health of the Republic Indonesia. Guidebook for Investigation and Management of Outbreaks of Infectious Diseases and Food Poisoning (Guidelines for Disease Epidemiology) Revision III. Jakarta: Directorate General of Disease Prevention and Control; 2020.
Khariri K, Muna F, Khoirudin Z. Distribution of Leptospirosis in Indonesia at 2017. Journal Annals of Tropical Medicine & Public Health. 2020;23(8):1267–1270. http://doi.org/10.36295/ASRO.2020.23812
Prihantoro T, Siwiendrayanti A. Karakteristik dan Kondisi Lingkungan Rumah Penderita Leptospirosis di Wilayah Kerja Puskesmas Pegandan. JHE: Journal of Health Education. 2017;2(2):185–191. https://doi.org/10.15294/jhe.v2i2.17187
Ramadhan MM, Devi S, Ismail TCM, Mulyani Z, Tosepu R. Hubungan Iklim Dengan Kejadian Penyakit Leptospirosis di Indonesia: Literatur Review. Jurnal Kesehatan Lingkungan: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan. 2020;17(1):57–62. https://doi.org/10.31964/jkl.v17i1.207
Flores B, Sheleby-Elias J, Pérez-Sánchez T, Fischer R, Múzquiz J, Fuertes H, et al. Leptospira spp in Rodents from Peridomestic Sites in Endemic Regions of Nicaragua. Ecohealth. 2020;17(4):469–476. https://doi.org/10.1007/s10393-021-01520-4
Ministry of Health of the Republic Indonesia. Final Report: Special Research on Disease Vectors and Reservoirs for DKI Jakarta Province 2018. Jakarta: Health Research and Development Agency; 2018.
Ministry of Health of the Republic Indonesia. Technical Guidelines for Leptospirosis Control. Jakarta: Ministry of Health of the Republic of Indonesia; 2022.
Tunissea A. Faktor Lingkungan Abiotik Pada Kejadian Leptospirosis. BALABA. 2008;7(2):23. https://ejournal2.litbang.kemkes.go.id/index.php/blb/article/view/750
Tunissea A. Faktor Lingkungan Biotik Pada Kejadian Leptospirosis. BALABA. 2009;5(02):26–27. https://ejournal2.litbang.kemkes.go.id/index.php/blb/article/view/1209
Levett PN. Leptospirosis. Clinical Microbiology Reviews. 2001;14(2):296–326. https://doi.org/10.1128/CMR.14.2.296
Setyaningsih Y, Bahtiar N, Kartini A, Pradigdo SF, Saraswati LD. The Presence of Leptospira sp. and Leptospirosis Risk Factor Analysis in Boyolali District, Indonesia. Journal of Public Health Research. 2022;11(1):1–6. https://doi.org/10.4081/jphr.2022.2144
Nugroho A, Joharina AS, Susanti L. Karakteristik Lingkungan Abiotik dan Potensi Keberadaan Leptospira Patogenik Di Air Dalam Kejadian Luar Biasa Leptospirosis Di Kota Semarang. Vektora: Jurnal Vektor dan Reservoir Penyakit. 2017;9(1):37–42. https://dx.doi.org/10.22435/vk.v9i1.5317.37-42
Khairani-Bejo S, Bahaman AR, Zamri-Saad M, Mutalib AR. The Survival of Leptospirosis Interrogans Serovar Hardjo in the Malaysian Environment. Journal of Animal and Veterinary Advances. 2004;3(3):123–129. https://medwelljournals.com/abstract/?doi=javaa.2004.123.129
Arumsari W, Sutiningsih D, Hestiningsih R. Analisis Faktor Lingkungan Abiotik yang Mempengaruhi Keberadaan Leptospirosis pada Tikus di Kelurahan Sambiroto, Kecamatan Tembalang, Kota Semarang. Jurnal Kesehatan Masyarakat. 2012;1(2):514–524. https://www.neliti.com/id/publications/18732/analisis-faktor-lingkungan-abiotik-yang-mempengaruhi-keberadaan-leptospirosis-pa#id-section-conten
Tangkanakul W, Tharmaphornpil P, Plikaytis BD, Bragg S, Poonsuksombat D, Choomkasien P, et al. Risk Factors Associated With Leptospirosis In Northeastern Thailand, 1998. American Journal of Tropical Medicine and Hygiene. 2000;63(3-4):204–208. https://doi.org/10.4269/ajtmh.2000.63.204
Kusmiyati SMN, Supar. Animal and Human Leptospirosis in Indonesia. Wartazoa. 2005;15(4):213–220. https://doi.org/10.14334/wartazoa.v15i4.820
Tunissea A. Spatial Analysis of Environmental Risk Factors on Leptospirosis Occurrence in Semarang City (as Early Warning System. Thesis. Semarang: Universitas Diponegoro; 2008.
Nursitasari HA. Analisis Perilaku dan Kondisi Rumah Ratproofing terhadap Kejadian Leptospirosis Di Kabupaten Ponorogo. Jurnal Kesehatan Lingkungan. 2019;11(3):198–207. https://doi.org/10.20473/jkl.v11i3.2019.198-207
Yanagihara Y, Villanueva SYAM, Nomura N, Ohno M, Sekiya T, Handabile C, et al. Leptospira is an Environmental Bacterium that Grows in Waterlogged Soil. Microbiology Spectrum. 2022;10(2):1–9. https://doi.org/10.1128/spectrum.02157-21
Cahyati WH, Kumalasari LD. Analisis Spasial Faktor Lingkungan Leptospirosis di Kecamatan Bonang Kabupaten Demak tahun 2018. Visikes. 2020;19(1):196–211. https://doi.org/10.33633/visikes.v19i01.3773
Ginting GKRB, Indiarjo S. Lingkungan, Perilaku Personal Hygiene, dan Pemakaian APD Terhadap Kejadian Leptospirosis. HIGEIA. 2022;6(2):236–250. https://doi.org/10.15294/higeia.v6i2.53916
Ningsih I, Wahid M. Leptospirosis Ditinjau dari Aspek Mikrobiologi. EKOTONIA. 2022;7(1):31–34. https://doi.org/10.33019/ekotonia.v7i1.3141
Dewi HC, Yudhastuti R. Faktor Risiko Kejadian Leptospirosis di Wilayah Kabupaten Gresik (Tahun 2017-2018). Jurnal Keperawatan Muhammadiyah. 2019;4(1):48–57. http://dx.doi.org/10.30651/jkm.v4i1.2014
Naing C, Reid SA, Aye SN, Htet NH, Ambu S. Risk Factors for Human Leptospirosis Following Flooding: A Meta-Analysis of Observational Studies. PLoS One. 2019;14(5):1–15. https://doi.org/10.1371/journal.pone.0217643
Nurhandoko F, Siwiendrayanti A. Zona Kerentanan Kejadian Leptospirosis ditinjau dari Sisi Lingkungan. HIGEIA. 2018;2(3):498–509. https://doi.org/10.15294/higeia.v2i3.23624
Ariani N, Wahyono TYM. Faktor - Faktor yang mempengaruhi Kejadian Leptospirosis di 2 Kabupaten Lokasi Surveilans Sentinel Leptospirosis Provinsi Banten Tahun 2017–2019. Jurnal Epidemiology Kesehatan Indonesia. 2020;4(2):57–64. http://dx.doi.org/10.7454/epidkes.v4i2.4063
Putri CPA, Saraswati LD, Adi MS, Hestiningsih R. Analisis Karakteristik Air, Bakteri Leptospira, dan Faktor Lingkungan pada Kasus Leptospirosis di Kabupaten Boyolali. Jurnal Kesehatan Masyarakat. 2019;7(4):195–202. https://doi.org/10.14710/jkm.v7i4.24366
Andriani R, Sukendra DM. Faktor Lingkungan dan Perilaku Pencegahan dengan Kejadian Leptospirosis di Daerah Endemis. HIGEIA. 2020;4(3):471–482. https://doi.org/10.15294/higeia.v4i3.33710
Kurniawati RD, Nuryati S. The Correlation Between Physical Environmental Factors and the Occurrence of Leptospirosis. KEMAS. 2018;14(2):223–230. https://doi.org/10.15294/kemas.v14i2.13527
Samekto M, Hadisaputro S, Adi MS, Suhartono, Widjanarko B. Faktor-Faktor yang berpengaruh terhadap Kejadian Leptospirosis (Studi Kasus Kontrol di Kabupaten Pati). JEKK. 2019;4(1):27–34. https://doi.org/10.14710/jekk.v4i1.4427
Zukhruf IA, Sukendra DM. Analisis Spasial Kasus Leptospirosis Berdasar Faktor Epidemiologi dan Faktor Risiko Lingkungan. HIGEIA. 2020;1(3):625–634. https://doi.org/10.15294/higeia.v4i4.36324
Nugroho A, Trapsilowati W, Yuliadi B, Indriyani S. Faktor Lingkungan Biotik dalam Kejadian Luar Biasa Leptospirosis di Kabupaten Tangerang, Banten. Vektora. 2018;10(2):89–94. https://doi.org/10.22435/vk.v10i2.1040
Febrian F, Solikhah. Analisis Spasial Kejadian Penyakit Leptospirosis di Kabupaten Sleman Propinsi Daerah Istimewa Yogyakarta Tahun 2011. KesMas. 2013;7(1):7–13. https://doi.org/10.12928/kesmas.v7i1.1012
Nordmeier TAKH. Estimating Population Density and Habitat Selection of Rats (Rattus Spp.) and Abundance of Birds on The Otago Peninsula. Thesis. New Zealand: University of Otago; 2020. https://ourarchive.otago.ac.nz/handle/10523/10384
Husni SH, Raharjo M. Faktor Lingkungan Yang Berpengaruh Terhadap Keberadaan Tikus Serta Identifikasi Bakteri Leptospira sp. di Pemukiman Sekitar Pasar Kota Semarang Tahun 2022. JKLI. 2023;22(2):134–141. https://doi.org/https://doi.org/10.14710/jkli.22.2.134-141
Priyanto D, Raharjo J, Rahmawati. Domestikasi Tikus: Kajian Perilaku Tikus dalam Mencari Sumber Pangan dan Membuat Sarang. BALABA. 2020;16(1):67–78. http://dx.doi.org/10.22435/blb.v16i1.2601
Siregar HM, Priyambodo S, Hindayana D. Analysis of the Movement of Rice Field Rats (Rattus argentiventer) Using the Linear Trap Barrier System. Gontor AGROTECH Science Journal. 2021;7(2):215–230. https://doi.org/http://dx.doi.org/10.21111/agrotech.v7i2.6208
Nur AYZ. Hubungan antara Penyimpanan Makanan dan Pembuangan Sisa Makanan dengan Keberadaan Tikus. JIIP. 2022;5(2):4008–4014. https://doi.org/10.54371/jiip.v5i10.933
Arrasit F, Wahyuni D. S Higiene Sanitasi terhadap Keberadaan Vektor Tikus di RT. 02 RW.03 Kecamatan Bantan Kabupaten Bengkalis Tahun 2021. Photon. 2022;12(2):133–140. https://doi.org/10.37859/jp.v12i2.3618
Arianti DW, Ramlan D, Utomo B. Hubungan Kebersihan Dapur dan Konstruksi Rumah dengan Keberadaan Tikus di Rumah Warga Dusun Majapahit Kelurahan Kalierang Kecamatan Bumiayu Kabupaten Brebes Tahun 2018. Buletin Keslingmas. 2019;38(2):226–233. https://doi.org/10.31983/keslingmas.v38i2.4881
Listianti DE, Suryono, Wartini. Faktor-Faktor yang Berhubungan dengan Kejadian Leptospirosis di Kabupaten Boyolali Jawa Tengah. JIKeMB. 2019;1(1):23–33. https://doi.org/10.32585/jikemb.v1i1.694
Notobroto HB, Mirasa YA, Rahman FS. Sociodemographic, Behavioral, and Environmental Factors Associated with The Incidence of Leptospirosis in Highlands of Ponorogo Regency, Province of East Java, Indonesia. Clinical Epidemiology and Global Health. 2021;12(100911):1–5. https://doi.org/10.1016/j.cegh.2021.100911
Ministry of Health of the Republic Indonesia. Technical Instructions for Leptospirosis Control - 3rd Printing. Jakarta: Directorate General of Disease Prevention and Control; 2017.
Suprayoga T, Kurniasih K, Widayanti R. Detection of Cattle Leptospirosis in Yogyakarta Based on Serology, Molecular, and Histopathological Tests. Advances in Animal and Veterinary Sciences. 2021;9(2):274–279. https://doi.org/10.17582/JOURNAL.AAVS/2021/9.2.274.279
Ruhiat E, Farhani NR, Kumorowati E, Dewi AP, Zunarto S. Identifikasi Kasus Leptospirosis pada Domba dan Kambing di Kabupaten Demak Tahun 2018. In: Penyakit Hewan Penyidikan Penyakit Hewan Rapat Teknis dan Pertemuan Ilmiah (RATEKPIL) dan Surveilans Kesehatan Hewan Tahun 2020. Jakarta: Direktorat Kesehatan Hewan; 2020. https://repository.pertanian.go.id/items/799c1458-95e2-44ea-9074-6bb88b27375d
Libonati HA, Santos GB, Souza GN, Brandí£o FZ, Lilenbaum W. Leptospirosis is Strongly Associated to Estrus Repetition on Cattle. Tropical Animal Health and Production. 2018;50(7):1625–1629. https://doi.org/10.1007/s11250-018-1604-9
Mulyani GT, Hartati S, Wuryastuty H, Tjahajati I, Yuriadi Y, Widiyono I, et al. Identifikasi Serovar Penyebab Leptospirosis pada Anjing di Yogyakarta. Jurnal Sain Veteriner. 2019;37(2):227-231. https://doi.org/10.22146/jsv.39201
Paz LN, Dias CS, Carvalho VMP de, Muramoto C, Estrela-Lima A, Pinna MH. Unusual Case of Polyarthritis and Hepatorenal Syndrome Associated with Leptospira Interrogans Infection in A Dog: A Case Report. Research in Veterinary Science. 2021;134:186–190. https://doi.org/10.1016/j.rvsc.2020.12.006
Mulyani GT, Raharjo S, Purnomo AB, Santoso Y, Kurnia, Wirapratiwi DK, et al. Leptospirosis pada Kucing di Yogyakarta dan Sekitarnya. Veteriner. 2018;19(36):1–5. https://doi.org/10.19087/jveteriner.2018.19.4
Ricardo T, Previtali MA, Signorini M. Meta-Analysis of Risk Factors for Canine Leptospirosis. Preventive Veterinary Medicine. 2020;181(105037):1–8. https://doi.org/10.1016/j.prevetmed.2020.105037
Daud A, Fuzi NMHM, Arshad MM, Kamarudin S, Mohammad WMZW, Amran F, et al. Leptospirosis Seropositivity and its Serovars among Cattle in Northeastern Malaysia. Veterinary World. 2018;11(6):840–844. https://doi.org/10.14202/vetworld.2018.840-844
Munawaroh SM, Widiyanto A, Atmojo JT, Duarsa ABS, Handayani RT, Rokhmayanti R, et al. Pengaruh Kondisi Selokan terhadap Kejadian Leptospirosis. Jurnal Keperawatan. 2022;14(S1):73–78. https://doi.org/10.32583/keperawatan.v14iS1.22
Tolistiawaty I, Hidayah N, Widayati AN. Faktor Lingkungan Abiotik dan Kejadian Leptospirosis pada Tikus di Desa Lalombi Kabupaten Donggala Sulawesi Tengah. In: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Ke-5. Surakarta: Universitas Muhammadiyah Surakarta; 2020. http://hdl.handle.net/11617/12249
Ahmadi H, Mufida DC, Syafriadi M. Determinan Aspek Lingkungan yang Berisiko Terjadinya Penularan Bakteri Leptospira sp dari Tikus Terkonfirmasi di Kabupaten Bondowoso. JKLI. 2023;22(1):1–12. https://doi.org/10.14710/jkli.22.1.1-12
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
1. Copyright of all journal manuscripts is held by the Jurnal Kesehatan Lingkungan.2. Formal legal provisions to access digital articles of electronic journal are subject to the provision of the Creative Commons Attribution-ShareAlike license (CC BY-NC-SA), which means that Jurnal Kesehatan Lingkungan is rightful to keep, transfer media/format, manage in the form of databases, maintain, and publish articles.
3. Published manuscripts both printed and electronic are open access for educational, research, and library purposes. Additionally, the editorial board is not responsible for any violations of copyright law.
JKESLING by UNAIR is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.