Systematic Review: Impact of Bisphenol-A (BPA) Exposure on Human Health
Introduction: One chemical substance used in producing epoxy resins and polycarbonate (PC) is called bisphenol-A (BPA). Three million tons of the chemical compound bisphenol-A are still produced annually. The amount of BPA produced in 2015 was 7.7 million tons; by 2022, 10.8 million tons are anticipated to be made. This study aimed to ascertain the effects of bisphenol-A exposure on human health. Discussion: This study used a systematic review method by collecting articles through online databases with a publication range of 2018 - 2024. The article search used the PRISMA flow diagram. The findings of 30 articles all examined the impact of BPA exposure on health. The level of exposure to bisphenol-A can have an impact on health due to the nature of BPA EDC (Endocrine Disrupting Hormone) which can inhibit the activity of natural hormones in the body. Conclusion: The impact on human health due to exposure to bisphenol-A such as cancer, obesity, disruption of reproductive health, hypertension, disrupting child development, and also behavioral changes in children. Bisphenol-A enters the body not only through food packaging but also through air and dust contaminated with BPA. The length of exposure and concentration of BPA affect its effects on the human body.
Andyna C, Ritonga NS. Sosialisasi Arti Simbol Segitiga Pada Kemasan Plastik Bagi Ibu Ibu Rumah Tangga. J Pengabdi Kreat. 2023;2(2):18-22. https://doi.org/10.29103/jpek.v2i2.13194
Nugroho B, Pramudya Y, Widodo W. The Content Analysis of Bisphenol A (BPA) on Water in Plastic Glass with Varying Temperatures and Contact Times using UV-VIS Spectrophotometer. Indones Rev Phys. 2018;1(2):27-32. https://doi.org/10.12928/irip.v1i2.263
Vasiljevic T, Harner T. Bisphenol A and Its Analogues in Outdoor and Indoor Air: Properties, Sources and Global Levels. Sci Total Environ. 2021;789(1):1-16. https://doi.org/10.1016/j.scitotenv.2021.148013
Prueitt RL, Hixon ML, Fan T, Olgun NS, Piatos P, Zhou J, et al. Systematic Review Of The Potential Carcinogenicity Of Bisphenol A In Humans. Regul Toxicol Pharmacol. 2023;142(1):1-38. https://doi.org/10.1016/j.yrtph.2023.105414
Sun F, Huang Y, Chen H, Huang J, Zhang L, Wei S, et al. BPA and Its Alternatives BPF and BPAF Exaggerate Hepatic Lipid Metabolism Disorders In Male Mice Fed A High Fat Diet. Sci Total Environ. 2023;867(1):1-10. https://doi.org/10.1016/j.scitotenv.2023.161521
Wang X, Nag R, Brunton NP, Bakar A, Harrison SM, Monahan FJ, et al. Risk Assessment of Bisphenol A (BPA) in Irish Meat and Meat Products. Sci Total Environ. 2023;881(1):1-8. https://doi.org/10.1016/j.scitotenv.2023.163496
Park YJ, Rahman MS, Pang WK, Ryu DY, Kim B, Pang MG. Bisphenol A Affects The Maturation And Fertilization Competence Of Spermatozoa. Ecotoxicol Environ Saf. 2020;196(1):1-13. https://doi.org/10.1016/j.ecoenv.2020.110512
Moreno-Gómez-Toledano R. Relationship Between Emergent BPA-Substitutes and Renal And Cardiovascular Diseases In Adult Population. Environ Pollut. 2022;313(5):1-9. https://doi.org/10.1016/j.envpol.2022.120106
Salamanca-fernández E, Rodríguez-barranco M, Amiano P, Delfrade J, Chirlaque MD, Colorado S, et al. Bisphenol-A Exposure and Risk of Breast and Prostate Cancer In The Spanish European Prospective Investigation Into Cancer and Nutrition Study. Environ Heal. 2021;88(20):1–12. https://doi.org/10.1186/s12940-021-00779-y
Nunn J, Chang S. What are Systematic Reviews. WikiJournal Med. 2020;7(1):1–11. https://doi.org/10.15347/wjm/2020.005
Maleki RK, Kaviani A, Omranipour R, Gholami M. Bisphenol‑A In Biological Samples Of Breast Cancer Mastectomy And Mammoplasty Patients and Correlation With Levels Measured In Urine and Tissue. Sci Rep. 2021;11:1–8. https://doi.org/10.1038/s41598-021-97864-6
Marotta V, Russo G, Gambardella C, Grasso M, La D, Grazia M, et al. Human Exposure To Bisphenol AF and Diethylhexylphthalate Increases Susceptibility To Develop Differentiated Thyroid Cancer In Patients With Thyroid Nodules. Chemosphere. 2019;218(1):885-894. https://doi.org/10.1016/j.chemosphere.2018.11.084
Zhan W, Tang W, Shen X, Xu H, Zhang J. Exposure To Bisphenol A and Its Analogs and Polycystic Ovarian Syndrome In Women of Childbearing Age : A Multicenter Case-Control Study. Chemosphere. 2023;313(1):1-9. https://doi.org/10.1016/j.chemosphere.2022.137463
Deng Y, He H, Wan H, Shen N, Li J, Zhang S, et al. Bisphenol A Exposure, Interaction With Genetic Variants and Colorectal Cancer Via Mediating Oxidative Stress Biomarkers. Environ Pollut. 2021;287(3):1-6. https://doi.org/10.1016/j.envpol.2021.117630
López L, Ángel C, Ortega M, Gómez H, Lucia R, Garciadiego H. Exposure To Bisphenol A and Breast Cancer Risk In Northern Mexican Women. Int Arch Occup Environ Health. 2021;94(1):699–706. https://doi.org/10.1007/s00420-020-01590-x
Bao W, Liu B, Rong S, Dai SY, Trasande L, Lehmler H. Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults. Environ Heal. 2020;3(8):1–10. https://doi.org/10.1001/jamanetworkopen.2020.11620
Hong X, Wang G, Liu X, Wu M, Zhang X, Hua X, et al. Lipidomic Biomarkers : Potential Mediators of Associations Between Urinary Bisphenol A Exposure and Colorectal Cancer. J Hazard Mater. 2022;427(11):1-7. https://doi.org/10.1016/j.jhazmat.2021.127863
Heng H, Deng Y, Wan H, Shen N, Li J, Zeng Q, et al. Urinary Bisphenol A And Its Interaction With CYP17A1 Rs743572 Are Associated With Breast Cancer Risk. Chemosphere. 2022;286(3):131880. https://doi.org/10.1016/j.chemosphere.2021.131880
Aquino CI, Troisi J, Antonio AD, Giugliano L. Endometrial Carcinoma and Bisphenol A : A Pilot Case-Control Study. J Sci Tech Res. 2019;21(4):16073-16079. https://doi.org/10.26717/BJSTR.2019.21.003641
Li J, Ji Z, Luo X, Li Y, Yuan P, Long J, et al. Urinary Bisphenol A and Its Interaction With ESR1 Genetic Polymorphism Associated with Non-Small Cell Lung Cancer : Findings from A Case-Control Study In Chines Population. Chemosphere. 2020;254(4):1-8. https://doi.org/10.1016/j.chemosphere.2020.126835
Sarink D, Franke AA, White KK, Wu AH, Cheng I, Quon B, et al. BPA, Parabens, and Phthalates In Relation To Endometrial Cancer Risk : A Case–Control Study Nested In The Multiethnic Cohort. Environ Heal. 2021;129(5):1–4. https://doi.org/10.1289/EHP8998
Wu AH, Franke AA, Wilkens LR, Tseng C, Conroy SM, Li Y, et al. Risk of Breast Cancer and Prediagnostic Urinary Excretion Of Bisphenol A, Triclosan and Parabens: The Multiethnic Cohort Study. Cancer Epidemiol. 2021;149(7):1426–1434. https://doi.org/10.1002/ijc.33692
Sun X, Li D, Liang H, Miao M, Song X, Wang Z. Maternal Exposure To Bisphenol A and Anogenital Distance Throughout Infancy : A Longitudinal Study From Shanghai , China. Environ Int. 2018;121(1):269–275. https://doi.org/10.1016/j.envint.2018.08.055
Caporossi L, Alteri A, Campo G, Paci E, Tranfo G, Capanna S, et al. Cross Sectional Study On Exposure To BPA and Phthalates and Semen Parameters In Men Attending A Fertility Center. Int J Environ Res Public Health. 2020;17(2):1-18. https://doi.org/10.3390/ijerph17020489
Benson TE, Gaml-sørensen A, Ernst A, Brix N, Hougaard KS, Hærvig KK, et al. Urinary Bisphenol A, F and S Levels and Semen Quality In Young Adult Danish Men. Int J Environ Res Public Health. 2021;18(4):1–12. https://doi.org/10.3390/ijerph18041742
Adoamnei E, Mendiola J, Vela-Soria F, Fernández MF, Olea N, Jørgensen N, et al. Urinary Bisphenol A Concentrations Are Associated With Reproductive Parameters In Young Men. Environ Res. 2018;161(1):122–128. https://doi.org/10.1016/j.envres.2017.11.002
Rodríguez-barranco M, Salamanca-fern E, Dolores M, Colorado-yohar S, Pedro J, Vela F. Bisphenol A Exposure and Risk of Ischemic Heart Disease In The Spanish European Prospective Investigation Into Cancer and Nutrition Study Nerea Larra. Chemosphere. 2020;261(7):1-10. https://doi.org/10.1016/j.chemosphere.2020.127697
Jiang S, Yang G, Zhou S, Zhang X, Peng C, Lu Q. Bisphenol A, S, and F Exposure, ESR1/2, CAT, and Enos Genetic Polymorphisms, and The Risk of Hypertension. Ecotoxicol Environ Saf. 2021;224(8):1-9. https://doi.org/10.1016/j.ecoenv.2021.112684
Kim JH, Cho YH, Hong YC. Microrna Expression In Response To Bisphenol A Is Associated with High Blood Pressure. Environ Int. 2020;141(5):1-8. https://doi.org/10.1016/j.envint.2020.105791
Jiang S, Liu H, Zhou S, Zhang X, Peng C, Zhou H, et al. Association Of Bisphenol A and Its Alternatives Bisphenol S and F Exposure With Hypertension and Blood Pressure: A Cross-Sectional Study in China. Environ Pollut. 2020;257(11):1-11. https://doi.org/10.1016/j.envpol.2019.113639
Mustieles V, Casas M, Ferrando-marco P, Ocón-hernández O, Reina-pérez I, Rodríguez-carrillo A, et al. Bisphenol A and Adiposity Measures In Peripubertal Boys From The Inma- Granada Cohort. Environ Res. 2019;173(3):443–451. https://doi.org/10.1016/j.envres.2019.03.045
Hong X, Zhou Y, Zhu Z, Li Y, Li Z, Zhang Y, et al. Environmental Endocrine Disruptor Bisphenol A Induces Metabolic Derailment and Obesity Via Upregulating IL-17A In Adipocytes. Environ Int. 2023;172(1):1-12 https://doi.org/10.1016/j.envint.2023.107759
Lee I, Joo Y, Joo M, Kim S, Choi S, Park J, et al. Associations Of Urinary Concentrations Of Phthalate Metabolites, Bisphenol A, and Parabens With Obesity And Diabetes Mellitus In A Korean Adult Population : Korean National Environmental Health Survey (KoNEHS ) 2015–2017. Environ Int. 2021;146(10):1-10. https://doi.org/10.1016/j.envint.2020.106227
Li Y, Zhang H, Kuang H, Fan R, Cha C, Li G, et al. Relationship Between Bisphenol A Exposure and Attention-Deficit/ Hyperactivity Disorder: A Case-Control Study For Primary School Children In Guangzhou, China. Environ Pollut. 2018;235(12):141–149. https://doi.org/10.1016/j.envpol.2017.12.056
Minatoya M, Araki A, Miyashita C, Ait Bamai Y, Itoh S, Yamamoto J, et al. Association Between Prenatal Bisphenol A And Phthalate Exposures And Fetal Metabolic Related Biomarkers: The Hokkaido study on Environment and Children’s Health. Environ Res. 2018;161(8):505–511. https://doi.org/10.1016/j.envres.2017.11.052
Shu X, Tang S, Peng C, Gao R, Yang S, Luo T, et al. Bisphenol A Is Not Associated With A 5-Year Incidence Of Type 2 Diabetes: A Prospective Nested Case–Control Study. Acta Diabetol. 2018;55(4):369–375. https://doi.org/10.1007/s00592-018-1104-4
Liang J, Pang L, Yang C, Long J, Liao Q, Tang P, et al. Effects Of Prenatal Single and Mixed Bisphenol Exposure On Bone Mineral Density In Preschool Children: A Population-Based Prospective Cohort Study. Ecotoxicol Environ Saf. 2023;267(8):1-11. https://doi.org/10.1016/j.ecoenv.2023.115665
Jiang Y, Li J, Xu S, Zhou Y, Zhao H, Li Y, et al. Prenatal Exposure To Bisphenol A and Its Alternatives and Child Neurodevelopment At 2 Years. J Hazard Mater. 2020;388(1):1-7. https://doi.org/10.1016/j.jhazmat.2019.121774
Wang G, Hong X, Yu J, Zhang Y, Li Y, Li Z, et al. Enhancing De Novo Ceramide Synthesis Induced By Bisphenol A Exposure Aggravates Metabolic Derangement During Obesity. Mol Metab. 2023;73(5):1-14. https://doi.org/10.1016/j.molmet.2023.101741
Moura HSRP, Rocha PRS, Amato AA, Sodré FF. Quantification Of Bisphenol A In Urine Samples From Children Studying In Public Schools From The Brazilian Capital. Microchem J. 2020;152(8):1-6. https://doi.org/10.1016/j.microc.2019.104347
Kannan K, Vimalkumar K. A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens. Front Endocrinol (Lausanne). 2021;12(1):1–19. https://doi.org/10.3389/fendo.2021.724989
Engin AB, Engin A. The Effect Of Environmental Bisphenol A Exposure On Breast Cancer Associated With Obesity. Environ Toxicol Pharmacol. 2021;81(1):1-12. https://doi.org/10.1016/j.etap.2020.103544
Engin AB, Engin A. The Effect Of Environmental Bisphenol A Exposure On Breast Cancer Associated With Obesity. Environ Toxicol Pharmacol. 2021;81(1):1-14. https://doi.org/10.1016/j.etap.2020.103544
Yaguchi T. The Endocrine Disruptor Bisphenol A Promotes Nuclear Errγ Translocation, Facilitating Cell Proliferation Of Grade I Endometrial Cancer Cells Via EGF-Dependent And EGF-Independent Pathways. Mol Cell Biochem. 2019;452(1):41–50. http://dx.doi.org/10.1007/s11010-018-3410-0
Ren F, Weng W, Zhang Q, Tan C, Xu M, Zhang M, et al. Clinicopathological Features And Prognosis Of AFP-Producing Colorectal Cancer: A Single-Center Analysis Of 20 Cases. Cancer Manag Res. 2019;11(1):4557–4567. https://doi.org/10.2147/CMAR.S196919
Huang Y, Sun F, Tan H, Deng Y, Sun Z, Chen H, et al. DEHP and DINP Induce Tissue- and Gender-Specific Disturbances in Fatty Acid and Lipidomic Profiles in Neonatal Mice: A Comparative Study. Environ Sci Technol. 2019;53(21):12812–12822. https://doi.org/10.1021/acs.est.9b04369
Zhang L, Zhang J, Fan S, Zhong Y, Li J, Zhao Y, et al. A Case-Control Study Of Urinary Concentrations Of Bisphenol A, Bisphenol F, And Bisphenol S and The Risk Of Papillary Thyroid Cancer. Chemosphere. 2023;312(1):1-7. https://doi.org/10.1016/j.chemosphere.2022.137162
Liang N, Song W, Li J. BPA Promotes Lung Fibrosis In Mice By Regulating Autophagy-Dependent Ferroptosis In Alveolar Epithelial Cells. Ecotoxicol Environ Saf. 2024;278(1):1-10. https://doi.org/10.1016/j.ecoenv.2024.116412
Hisa Faadhilah, Ami Tiitraresm. Review: Pencemaran Bisphenol A (BPA) dalam Kemasan Galon dan Dampaknya Bagi Kesehatan. Farmaka. 2023;21(2):223–229. https://doi.org/10.24198/farmaka.v21i2.46546.g20651
Li X, Mo J, Zhu Q, Ni C, Wang Y, Li H, et al. The Structure–Activity Relationship (SAR) for Phthalate-Mediated Developmental and Reproductive Toxicity In Males. Chemosphere. 2019;223(1):504–513. https://doi.org/10.1016/j.chemosphere.2019.02.090
Rudnicka E, Suchta K, Grymowicz M, Calik‐ksepka A, Smolarczyk K, Duszewska AM, et al. Chronic Low Grade Inflammation In Pathogenesis Of Pcos. Int J Mol Sci. 2021;22(7):1–12. https://doi.org/10.3390/ijms22073789
Leader J, Mínguez-Alarcón L, Williams PL, Ford JB, Dadd R, Chagnon O, et al. Paternal and Maternal Preconception and Maternal Pregnancy Urinary Phthalate Metabolite and BPA Concentrations In Relation To Child Behavior. Environ Int. 2024;183(1):1-10. https://doi.org/10.1016/j.envint.2023.108337
Yao J, Wang J, Wu L, Lu H, Wang Z, Yu P, et al. Perinatal Exposure To Bisphenol A Causes A Disturbance Of Neurotransmitter Metabolic Pathways In Female Mouse Offspring: A Focus On The Tryptophan and Dopamine Pathways. Chemosphere. 2020;254(1):1-11. https://doi.org/10.1016/j.chemosphere.2020.126715
Perez-Bermejo M, Mas-Perez I, Murillo-llorente MT. The Role of Bisphenol A in Diabetes and Obesity. Biomedicines. 2021;9(6):1–17. https://doi.org/10.3390/biomedicines9060666
Hägglöf T, Vanz C, Kumagai A, Dudley E, Ortega V, Siller M, et al. T-Bet+ B Cells Accumulate In Adipose Tissue and Exacerbate Metabolic Disorder During Obesity. Cell Metab. 2022;34(8):1121-1136 https://doi.org/10.1016/j.cmet.2022.07.002
Lu X, Li M, Wu C, Zhou C, Zhang J, Zhu Q, et al. Bisphenol A Promotes Macrophage Proinflammatory Subtype Polarization Via Upregulation Of IRF5 Expression In Vitro. Toxicol Vitr. 2019;60(1):97–106. https://doi.org/10.1016/j.tiv.2019.05.013
Díaz Santana M V, Hankinson SE, Bigelow C, Sturgeon SR, Zoeller RT, Tinker L, et al. Urinary Concentrations Of Phthalate Biomarkers and Weight Change Among Postmenopausal Women: A Prospective Cohort Study. Environ Heal A Glob Access Sci Source. 2019;18(1):1–12. https://doi.org/10.1186/s12940-019-0458-6
Jiang W, Ding K, Huang W, Xu F, Lei M, Yue R. Potential Effects Of Bisphenol A On Diabetes Mellitus and Its Chronic Complications : A Narrative Review. Heliyon. 2023;9(5):1-11. https://doi.org/10.1016/j.heliyon.2023.e16340
García-Recio E, Costela-Ruiz VJ, Melguizo-Rodriguez L, Ramos-Torrecillas J, García-Martínez O, Ruiz C, et al. Repercussions of Bisphenol A on the Physiology of Huma Osteoblasts. Int J Mol Sci. 2022;23(10):1-11. https://doi.org/10.3390/ijms23105349
Atay E, Ertekin T, Yılmaz H, Güler HS, Al Ö, Nisari M, et al. Impact Of Prenatal Exposure To Bisphenol A On Pregnant Rats: Fetal Bone Development and Immunohistochemistry Implications. Toxicol Ind Health. 2019;35(2):119–135. https://doi.org/10.1177/0748233718823146
Irene Putri S, Sani Fajriah A, Arradini D, Widiyanto A, Tri Atmojo J. Pengaruh Bisphenol a Terhadap Perilaku Anak. Avicenna J Heal Res. 2021;4(1):57–68. https://doi.org/10.36419/avicenna.v4i1.459
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