Bioanthropological and Biomechanical Perspectives on Skeletal Senescence Variation: A Literature Review
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Background: Senescence is the deterioration of the body's biological and physiological function throughout later life. Senescent populations are more prone to diseases, though other than osteoporosis, skeletal senescence is a less discussed topic in Indonesia. Furthermore, a global and national increase in the aging population showed that they will be a major group in society, thus raising the urgency to review this matter. This study aims to comprehend the physiological and biomechanical mechanisms of skeletal senescence, as well as senescent variations in a certain sex or population affinity.
Literature Review: Age-related skeletal cellular death and imbalance contribute to bone damage in elders. Senescence also affects skeletal biomechanics, expressed in increased bone porosity and brittleness. Stresses in aged bone risk straining above its elastic limit and causing fractures due to its inability to tolerate stresses. The loss of sex hormones is related to skeletal senescence, especially in females, though the effects of testosterone on skeletal senescence are underresearched. Dietary change, estrogen replacement therapy, and calcitonin consumption are effective measures in reducing the effects of osteoporosis. Variations were found in the bone aging process in different populations, especially regarding bone mineral density loss in white, African-American, Asian, and Hispanic populations.
Summary: Specific population-based healthcare services in geriatrics and gerontology are highly suggested to ensure inclusive healthcare for every aged individual. Due to the minimum data about bone aging in Indonesia (other than osteoporosis), the authors encourage data procurement on local populations to create more suitable medical guidelines for elders in Indonesia.
Chalise HN. Aging: Basic Concept. Am J Biomed Sci Res. 2019;1(1):8–10.
Nanzadsuren T, Myatav T, Dorjkhuu A, Ganbat M, Batbold C, Batsuuri B, et al. Skin aging risk factors: A nationwide population study in Mongolia risk factors of skin aging. PLoS One [Internet]. 2022;17(1 January). Available from: http://dx.doi.org/10.1371/journal.pone.0249506
Anwar SS, Smith SD, Pongprutthipan M, Kim JY, Yuan C, van Steensel M. Preageing of the skin among Asian populations. JEADV Clin Pract. 2022;1(1):1–8.
Nouveau-Richard S, Yang Z, Mac-Mary S, Li L, Bastien P, Tardy I, et al. Skin aging: A comparison between Chinese and European populations: A pilot study. J Dermatol Sci. 2005;40(3):187–93.
Guyuron B, Rowe DJ, Weinfeld AB, Eshraghi Y, Fathi A, Iamphongsai S. Factors contributing to the facial aging of identical twins. Plast Reconstr Surg. 2009;123(4):1321–31.
Keaney TC. Aging in the Male Face: Intrinsic and Extrinsic Factors. Dermatologic Surg. 2016;42(7):797–803.
McCallion R, Li A, Po W. Dry and photo-aged skin: manifestations and management. J Clin Pharm Ther. 1993;18(1):15–32.
Janovska J, Voicehovska J. Lifestyle and nutrition peculiarities as risk factors for precancerous skin lesions and premature skin aging in Latvian citizens. J Men's health [Internet]. 2011 Oct;8(3):233. Available from: http://online.liebertpub.com/doi/10.1016/j.jomh.2011.08.077
Bulpitt CJ, Markowe HLJ, Shipley MJ. Why do some people look older than they should? Postgrad Med J. 2001;77(911):578–81.
Wilmore JH. The aging of bone and muscle. Clin Sports Med. 1991;10(2):231–44.
Martin B. Aging and strength of bone as a structural material. Calcif Tissue Int. 1993;53(1 Supplement):34–40.
Wei Y, Sun Y. Aging of the Bone. In: Advances in Experimental Medicine and Biology [Internet]. 2018. p. 189–97. Available from: http://link.springer.com/10.1007/978-981-13-1117-8_12
Almeida M. Aging mechanisms in bone. Bonekey Rep [Internet]. 2012 Jul 4;1(7):1–7. Available from: http://dx.doi.org/10.1038/bonekey.2012.102
Trotter M, Gleser G. The effect of aging on stature. Am J Phys Anthropol [Internet]. 1951 Sep;9(3):311–24. Available from: https://onlinelibrary.wiley.com/doi/10.1002/ajpa.1330090307
Pignolo RJ, Law SF, Chandra A. Bone Aging, Cellular Senescence, and Osteoporosis. JBMR Plus. 2021;5(4):1–14.
Osterhoff G, Morgan EF, Shefelbine SJ, Karim L, McNamara LM, Augat P. Bone mechanical properties and changes with osteoporosis. Injury [Internet]. 2016;47:S11–20. Available from: http://dx.doi.org/10.1016/S0020-1383(16)47003-8
Zimmermann EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, et al. Correction for Zimmermann et al., Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci [Internet]. 2012 Jul 17;109(29):11890–11890. Available from: https://pnas.org/doi/full/10.1073/pnas.1209596109
Burr DB. Changes in bone matrix properties with aging. Bone [Internet]. 2019 Mar;120:85–93. Available from: https://linkinghub.elsevier.com/retrieve/pii/S875632821830382X
Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength. Osteoporos Int [Internet]. 2006 Mar 9;17(3):319–36. Available from: http://link.springer.com/10.1007/s00198-005-2035-9
Ramadani M. Faktor-Faktor Resiko Osteoporosis dan Upaya Pencegahannya. J Kesehat Masy Andalas [Internet]. 2010;4(2):111–5. Available from: http://jurnal.fkm.unand.ac.id/index.php/jkma/article/view/78#:~:text=Karena inilah osteoporosis sering disebut,%2C riwayat keluarga%2C menopause%2C penggunaan
Sihombing I, Wangko S, Kalangi SJR. Peran Estrogen Pada Remodeling Tulang. J Biomedik. 2013;4(3):S18–28.
Syam Y. Kesehatan Praktis Mengenal Mencegah Terjadinya Fraktur. e-CliniC. 2015;2(2).
Beck TJ, Ruff CB, Scott WW, Plato CC, Tobin JD, Quan CA. Sex differences in geometry of the femoral neck with aging: A structural analysis of bone mineral data. Calcif Tissue Int. 1992;50(1):24–9.
Brown M. Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Educ [Internet]. 2008 Jun;32(2):120–6. Available from: https://www.physiology.org/doi/10.1152/advan.90111.2008
Russo CR, Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Volpato S, et al. Aging bone in men and women: beyond changes in bone mineral density. Osteoporos Int [Internet]. 2003 Jul 24;14(7):531–8. Available from: http://link.springer.com/10.1007/s00198-002-1322-y
Seeman E. During aging, men lose less bone than women because they gain more periosteal bone, not because they resorb less endosteal bone. Calcif Tissue Int. 2001;69(4):205–8.
Mazess RB. On aging bone loss. Clin Orthop Relat Res. 1982;165(2):239–52.
Zengin A, Prentice A, Ward KA. Ethnic differences in bone health. Front Endocrinol (Lausanne) [Internet]. 2015 Mar 17;6(March):1–6. Available from: http://www.frontiersin.org/Bone_Research/10.3389/fendo.2015.00024/abstract
Tschachler E, Morizot F. Ethnic Differences in Skin Aging. In: Gilchrest BA, Krutmann J, editors. Skin Aging. Springer, Berlin, Heidelberg; 2006. p. 23–31.
United Nations Department of Economic and Social Affairs Population Division. World Population Prospects 2022 [Internet]. 2022. Available from: https://population.un.org/wpp/Publications/Files/WPP2022_Data_Sources.pdf
Sari NR, Yulianto KT, Agustina R, Wilson H, Nugroho SW, Anggraeni G. Statistik Penduduk Lanjut Usia 2023 [Internet]. Jakarta; 2023. Available from: https://webapi.bps.go.id/download.php?f=ujNS4ev+vfiMEaan1TfkykQGKpKKa5FxxaklRT64LE2XLihP86hpMI94QbsxwmRgoMDdGoY66mDlPOs5axhsaNi6NdjbUVDXg5Y/nev3vui83vFxra7RRkiQ+Tq840EdpujkibysVkTfQn1aLTAAT42XQL6jY2PrqbrcjWYVeJcFYv2a56sSrp73WdUF5ux1jfp2lURq693fy4W0TQnxO+1wBH8e/8+D8mRTLi/VjD6vT5ex5nPEzFUDlmnQKyChNe/q0UErhIHgP2IMV83hUQ==
Tanaya ARR, Yasa IGWM. Kesejahteraan Lansia dan Beberapa Faktor yang Mempengaruhi di Desa Dangin Puri Kauh. Piramida [Internet]. 2015;11(1):8–12. Available from: https://jurnal.harianregional.com/piramida/full-18708
Cicih LHM, Agung DN. Lansia di era bonus demografi. J Kependud Indones [Internet]. 2022 Oct 18;17(1):1. Available from: https://ejurnal.kependudukan.lipi.go.id/index.php/jki/article/view/636
Rodan GA. Introduction to bone biology. Bone [Internet]. 1992;13:S3–6. Available from: http://dx.doi.org/10.1016/S8756-3282(09)80003-3
Manolagas SC, Parfitt AM. What old means to bone. Trends Endocrinol Metab [Internet]. 2010 Jun;21(6):369–74. Available from: https://linkinghub.elsevier.com/retrieve/pii/S104327601000024X
Owen R, Reilly GC. In vitro Models of Bone Remodelling and Associated Disorders. Front Bioeng Biotechnol [Internet]. 2018 Oct 11;6(OCT):1–22. Available from: https://www.frontiersin.org/article/10.3389/fbioe.2018.00134/full
Grzibovskis M, Pilmane M, Urtane I. Today's understanding about bone aging. Stomatol Balt Dent Maxillofac J. 2010;12(4):99–104.
Dominguez LJ, Bella G Di, Belvedere M, Barbagallo M. Physiology of the aging bone and mechanisms of action of bisphosphonates. Biogerontology. 2011;12(5):397–408.
Hoffman CM, Han J, Calvi LM. Impact of aging on bone, marrow and their interactions. Bone [Internet]. 2019;119(July):1–7. Available from: https://doi.org/10.1016/j.bone.2018.07.012
Kloss FR, Gassner R. Bone and aging: Effects on the maxillofacial skeleton. Exp Gerontol. 2006;41(2):123–9.
Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33(6):919–26.
Demontiero O, Vidal C, Duque G. Aging and bone loss: new insights for the clinician. Ther Adv Musculoskelet Dis [Internet]. 2012 Apr 14;4(2):61–76. Available from: http://journals.sagepub.com/doi/10.1177/1759720X11430858
Okuno E, Fratin L. Biomechanics of the Human Body [Internet]. Ashby N, Brantley W, Fowler M, Inglis M, Sassi E, Sherif H, editors. New York, NY: Springer New York; 2014. 176 p. (Undergraduate Lecture Notes in Physics). Available from: http://link.springer.com/10.1007/978-1-4614-8576-6
Gomez MA, Nahum AM. Biomechanics of Bone. In: Accidental Injury [Internet]. New York, NY: Springer New York; 2002. p. 206–27. Available from: http://link.springer.com/10.1007/978-0-387-21787-1_10
Bartlett R. Sports Biomechanics: Reducing Injury and Improving Performance. New York: Routledge; 1999.
Morgan EF, Bouxsein ML. Biomechanics of Bone and Age-Related Fractures. In: Principles of Bone Biology [Internet]. Elsevier; 2008. p. 29–51. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780123738844000240
Özkaya N, Nordin M, Goldsheyder D, Leger D. Fundamentals of Biomechanics [Internet]. 3rd ed. York N, editor. New York, NY: Springer New York; 2012. 1–449 p. Available from: http://link.springer.com/10.1007/978-1-4614-1150-5
Keaveny TM, Hayes WC. A 20-Year Perspective on the Mechanical Properties of Trabecular Bone. J Biomech Eng [Internet]. 1993 Nov 1;115(4B):534–42. Available from: https://asmedigitalcollection.asme.org/biomechanical/article/115/4B/534/399577/A-20Year-Perspective-on-the-Mechanical-Properties
Schaffler MB, Burr DB. Stiffness of compact bone: Effects of porosity and density. J Biomech [Internet]. 1988 Jan;21(1):13–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/0021929088901868
Ur R W. Effect of Age on the Elastic Modulus of Bone. J Bioeng Biomed Sci [Internet]. 2017;07(01):1–4. Available from: https://www.omicsonline.org/open-access/effect-of-age-on-the-elastic-modulus-of-bone-2155-9538-1000219.php?aid=86918
Hart NH, Nimphius S, Rantalainen T, Ireland A, Siafarikas A, Newton RU. Mechanical basis of bone strength: Influence of bone material, bone structure and muscle action. J Musculoskelet Neuronal Interact [Internet]. 2017;17(3):114–39. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601257/pdf/JMNI-17-114.pdf
Granke M, Makowski AJ, Uppuganti S, Nyman JS. Prevalent role of porosity and osteonal area over mineralization heterogeneity in the fracture toughness of human cortical bone. J Biomech [Internet]. 2016;49(13):2748–55. Available from: http://dx.doi.org/10.1016/j.jbiomech.2016.06.009
Zioupos P. Ageing Human Bone: Factors Affecting its Biomechanical Properties and the Role of Collagen. J Biomater Appl [Internet]. 2001 Jan 27;15(3):187–229. Available from: http://journals.sagepub.com/doi/10.1106/5JUJ-TFJ3-JVVA-3RJ0
Wang D, Wang H. Cellular Senescence in Bone. In: Heshmati HM, Brzozowski T, editors. Mechanisms and Management of Senescence [Internet]. IntechOpen; 2022. p. 1–18. Available from: https://www.intechopen.com/chapters/79828
Porrelli D, Abrami M, Pelizzo P, Formentin C, Ratti C, Turco G, et al. Trabecular bone porosity and pore size distribution in osteoporotic patients – A low field nuclear magnetic resonance and microcomputed tomography investigation. J Mech Behav Biomed Mater [Internet]. 2022 Jan;125(104933). Available from: https://linkinghub.elsevier.com/retrieve/pii/S1751616121005646
Cooper DML, Kawalilak CE, Harrison K, Johnston BD, Johnston JD. Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It? Curr Osteoporos Rep [Internet]. 2016 Oct 13;14(5):187–98. Available from: http://link.springer.com/10.1007/s11914-016-0319-y
Sharir A, Barak MM, Shahar R. Whole bone mechanics and mechanical testing. Vet J [Internet]. 2008 Jul;177(1):8–17. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1090023307003292
KováÄik J. Correlation between Young's modulus and porosity in porous materials. J Mater Sci Lett. 1999;18(13):1007–10.
Callister WD. Fundamentals of Materials Science and Engineering: An Interactive e-Text. 5th ed. New York, NY: John Wiley and Sons, Inc.; 2015. 324–346 p.
WHO Scientific Group on the Prevention and Management of Osteoporosis. Prevention and Management of Osteoporosis: Report of a WHO Scientific Group [Internet]. Vol. 921, WHO Technical Report Series. Geneva; 2003. Available from: https://apps.who.int/iris/bitstream/handle/10665/42841/WHO_TRS_921.pdf;jsessionid=F3E82E08F14075113F731C81E5866CEA?sequence=1
Tucker K. Dietary Intake and Bone Status with Aging. Curr Pharm Des. 2005;9(32):2687–704.
Kusdhanil L, Mulyono G, Baskara ES, Oemardir M, Rahardjo TBW. Kualitas Tulang Mandibula pada Wanita Pasca Menopause. J Kedokt Gigi Univ Indones. 2000;7(Edisi Khusus):673–8.
Curtis E, Litwic A, Cooper C, Dennison E. Determinants of Muscle and Bone Aging. J Cell Physiol. 2015;230(11):2618–25.
Thadius TGL, Lengkong AC, Wagiu AMJ. Gambaran Waktu Tunggu Operasi Hip Replacement pada Pasien Manula dengan Patah Tulang Pinggul Periode November 2017-Desember 2018 di RSUP Prof. Dr. R. D. Kandou Manado. e-CliniC. 2019;8(1):67–72.
Schulman RC, Weiss AJ, Mechanick JI. Nutrition, bone, and aging: An integrative physiology approach. Curr Osteoporos Rep. 2011;9(4):184–95.
Boskey AL, Imbert L. Bone quality changes associated with aging and disease: a review. Ann N Y Acad Sci [Internet]. 2017 Dec;1410(1):93–106. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774017/pdf/nihms920779.pdf
Boskey AL, Coleman R. Critical reviews in oral biology & medicine: Aging and bone. J Dent Res. 2010;89(12):1333–48.
Nam H-S, Shin M-H, Zmuda JM, Leung PC, Barrett-Connor E, Orwoll ES, et al. Race/ethnic differences in bone mineral densities in older men. Osteoporos Int [Internet]. 2010 Dec 4;21(12):2115–23. Available from: http://link.springer.com/10.1007/s00198-010-1188-3
Baker PT, Angel JL. Old Age Changes in Bone Density: Sex, and Race Factors in the United States. Hum Biol [Internet]. 1965 May;37(2):104–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14325444
Windhager S, Mitteroecker P, Rupić I, Lauc T, PolaÅ¡ek O, Schaefer K. Facial aging trajectories: A common shape pattern in male and female faces is disrupted after menopause. Am J Phys Anthropol. 2019;169(4):678–88.
Seeman E. Growth in Bone Mass and Size”Are Racial and Gender Differences in Bone Mineral Density More Apparent than Real? J Clin Endocrinol Metab [Internet]. 1998 May;83(5):1414–9. Available from: https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.83.5.4844
Schwartz A V, Sellmeyer DE, Strotmeyer ES, Tylavsky FA, Feingold KR, Resnick HE, et al. Diabetes and Bone Loss at the Hip in Older Black and White Adults. J Bone Miner Res [Internet]. 2005 Apr 4;20(4):596–603. Available from: https://asbmr.onlinelibrary.wiley.com/doi/10.1359/JBMR.041219
Cohn SH, Abesamis C, Yasumura S, Aloia JF, Zanzi I, Ellis KJ. Comparative skeletal mass and radial bone mineral content in black and white women. Metabolism [Internet]. 1977 Feb;26(2):171–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/002604957790052X
Luckey MM, Wallenstein S, Lapinski R, Meier DE. A prospective study of bone loss in African-American and white women--a clinical research center study. J Clin Endocrinol Metab [Internet]. 1996 Aug;81(8):2948–56. Available from: https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.81.8.8768857
Looker AC, Melton LJ, Harris TB, Borrud LG, Shepherd JA. Prevalence and trends in low femur bone density among older US adults: NHANES 2005–2006 compared with NHANES III. J Bone Miner Res. 2010 Jan;25(1):64–71.
Melton LJ. The Prevalence of Osteoporosis: Gender and Racial Comparison. Calcif Tissue Int [Internet]. 2001 Oct 27;69(4):179–81. Available from: http://link.springer.com/10.1007/s00223-001-1043-9
Taaffe DR, Villa ML, Holloway L, Marcus R. Bone mineral density in older non-Hispanic Caucasian and Mexican-American women: relationship to lean and fat mass. Ann Hum Biol [Internet]. 2000 Jan 9;27(4):331–44. Available from: http://www.tandfonline.com/doi/full/10.1080/03014460050044829
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