METHYLATION RELATED TO BENEFIT AND HARM IN RNAI APPLICATION: AN EPIGENETIC QUASI SYSTEMATIC REVIEW
Downloads
Background: Double stranded RNA (dsRNA), siRNA, miRNA, RNAi, induce DNA methylation in plants and in mammalian cells, including human. Methylation of CpG island and repeat CGG DNA is high prevalence cases in tropical rain forest, but had been neglected till now. Purpose: Aims are knowing the effect of gene silencing to the environment, whereas RNAi cause hypermethylation. Methods: The manuscript was Quasi Systematic Review with Bayesian Analysis. Results: The result used Science Direct search engine, 935 references are caught, plus 11 references from already recorded in Mendeley library and after screening the abstract or title, 920 are excluded with the not relevant either duplication analyzed with the newest Bayesian network to answer the hypothesis. Screening full text of the 18, plus 10 references from already recorded in Mendeley library, then 16 full text were chosen. The chasing 28 full text were check and recheck with meta-analysis of RNAi-methylation using Science Direct (12 references). Conclusion: All of the studies described above indicated that RNAi and CRISPR/Cas9- mediated editing in plant, fishery, mammals, human, based on methylation and demethylation technique set-up by siRNA, miRNA or CRISPR/Cas9.
Adlhiyati, Z. 2009. Produk Rekayasa Genetika
(GMO/GeneticallyModified Organism) Sebagai Subjek Perlindungan Patent dan Perlindungan Varietas Tanaman. Thesis, Universitas Diponegoro Semarang.
Ardian, F. 2018. Pertama di Jatim, Banyuwangi Bangun Kampung Sidat. DetikNews/Berita Jawa Timur.
Braga, L. da C. et al. 2014. Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cance. Biomedicine and Pharmacotherapy, 68(1), pp. 87–91. doi:10.1016/j.biopha.2013.12.004.
De Carvalho, D. et al. 2012. DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival. Cancer Cell, 21(5), pp. 655–67. doi: 10.1016/j.ccr.2012.03.045.
Choi, K. mi et al. 2014. Tumor-specific delivery of siRNA using supramolecular assembly of hyaluronic acid nanoparticles and 2b RNA-binding protein/siRNA complexes. Biomaterials, 35(25), pp. 7121–32. doi: 10.1016/j.biomaterials.2014.04.096.
Chuai, G. hui, Wang, Q. L. and Liu, Q. 2017. In Silico Meets In Vivo: Towards Computational CRISPR-Based sgRNA Design. Trends in Biotechnology. doi: 10.1016/j.tibtech.2016.06.008.
Desai, M. and Chauhan, J. 2016. In silico analysis of nsSNPs in human methyl CpG binding protein 2. Meta Gene. doi: 10.1016/j.mgene.2016.09.004.
Gabriel, A. F. et al. 2019. Si vis pacem para bellum: A prospective in silico analysis of miRNA-based plant defenses against fungal infections. Plant Science. doi: 10.1016/j.plantsci.2019.110241.
Gentile, E. et al. 2017. Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics. Oncotarget, 8(29), pp. 48222–39. doi: 10.18632/oncotarget.18421.
Holoch, D and Moazed, D. 2015. RNA-Mediated Epigenetic Regulation of Gene Expressi. Nat Rev Genet, 16(2), pp. 71–84.
Kistijani Samsuria Mutalib, P. et al. 2017. LGBTQ: The Molecular Mechanism and its Role in Elucidating Proportional for a Better Management. International Journal of Environmental and Agriculture Research, 3(9), pp. 23–29. doi: 10.25125/agriculture-journal-ijoear-sep-2017-6.
Kui, L. et al. 2017. Building a genetic manipulation tool box for orchid biology: Identification of constitutive promoters and application of CRISPR/Cas9 in the orchid, dendrobium officinale. Frontiers in Plant Science, 8(2036), pp. 1–13. doi: 10.3389/fpls.2016.02036.
Li, W. et al. 2011. Knockdown of SAMS genes encoding S-adenosyl-l- methionine synthetases causes methylation alterations of DNAs and histones and leads to late flowering in rice. Journal of Plant Physiology, 168(15), pp. 1837–43. doi: 10.1016/j.jplph.2011.05.020.
Liu, Z, Hui, Y, Shi, L, Chen, Z, Xu, X, Chi, L. 2016. Efficient CRISPR/Cas9-Mediated Versatile, Predictable, and Donor-Free Gene Knockout in Human Pluripotent Stem Cells. Stem Cell Reports, 7(3), pp. 496–507.
Movahedi, A. et al. 2015. RNA- directed DNA methylation in plants. Plant Cell Reports, 34(11), pp. 1857–62. doi: 10.1007/s00299-015-1839-0.
Muthusamy, V., Bosenberg, M. and Wajapeyee, N. 2010. Redefining regulation of DNA methylation by RNA interference. Genomics, 96(4), pp. 191–198. doi: 10.1016/j.ygeno.2010.07.001.
Nakayasu, M. et al. 2018. Generation of α-solanine-free hairy roots of potato by CRISPR/Cas9 mediated genome editing of the St16DOX gene. Plant Physiology and Biochemistry. doi:
1016/j.plaphy.2018.04.026.
Nechaev, S. et al. 2013. Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape. Journal of Controlled Release, 170(3), pp. 307–315. doi: 10.1016/j.jconrel.2013.06.007.
Reautschnig, P., Vogel, P. and Stafforst, T. 2017. The notorious R.N.A. in the spotlight - drug or target for the treatment of disease. RNA Biology, 14(5), pp. 651–668. doi: 10.1080/15476286.2016.1208323.
Reinhard, S. and Wagner, E. 2017. How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides. Macromolecular Bioscience, 17(1). doi: 10.1002/mabi.201600152.
Song, L. et al. 2019. MiR-362-3p is downregulated by promoter methylation and independently predicts shorter OS of cervical squamous cell carcinoma. Biomedicine and Pharmacotherapy. doi: 10.1016/j.biopha.2019.108944.
Swanton, C., Nicke, B. and Downward, J. 2004. RNA interference, DNA methylation, and gene silencing: A bright future for cancer therapy? [1]. Lancet Oncology, 5(11), pp. 653–654. doi: 10.1016/S1470- 2045(04)01604-3.
Ting, A. H. et al. 2004. CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nature Genetics, 36(6), pp. 582–4. doi: 10.1038/ng1365.
Titze-de-Almeida, R., David, C. and Titze-deAlmeida, S. S. 2017.
The Race of 10 Synthetic RNAi-Based Drugs to the
Vinutha, T. et al. 2018. Tomato geminivirus encoded RNAi suppressor protein, AC4 interacts with host AGO4 and precludes viral DNA methylation. Gene, 678, pp. 184–95. doi: 10.1016/j.gene.2018.08.009.
Wang, X. et al. 2018. DNA methylation on N6adenine in lepidopteran Bombyx mori. Biochimica et Biophysica Acta – GeneRegulatory Mechanisms, 1861(9), pp. 815– 25. doi: 10.1016/j.bbagrm.2018.07.013.
Xie, M and Yu, B. 2015. siRNA-Directed DNA Methylation in Plants. Curent Genomics, 16, pp. 23–31. Pharmaceutical Market. Pharmaceutical Research, 34(7), pp. 1339–1363. doi: 10.1007/s11095-017-2134-2
Yu, R., Wang, X. and Moazed, D. 2018. Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
Nature, 558(7711), pp. 615–9. doi: 10.1038/s41586-018-0239-3.
Zhu, X. et al. 2018. Whole-genome RNAi screen identifies methylation-related genes influencing lipid metabolism in Caenorhabditis elegans. Journal of Genetics and Genomics, 45(5), pp. 259–272. doi: 10.1016/j.jgg.2018.03.005
Copyright (c) 2020 Journal of Public Health Research and Community Health Development
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author. In order to be accepted and published by JPH RECODE, author(s) submitting the article manuscript should complete all the review stages. By submitting the manuscript, the author(s) agreed to these following terms:
The copyright of accepted articles shall be assigned to JPH RECODE as the publisher of the journal. The intended copyright includes the rights to publish articles in various forms (including reprints). JPH RECODE maintain the publishing rights to the published articles.
Authors are permitted to disseminate published article by sharing the link/DOI of the article at JPH RECODE. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission form JPH RECODE with an acknowledgement of initial publication to this journal.
The Copyright Transfer Agreement Form can be downloaded ON THIS FORM.
