TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION
TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION
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Maxillofacial bone defects due to tumor resection, trauma or infections should be reconstructed to
maintain the bone continuity in order to preserve its masticatory, speech and esthetic functions.
Autogenous bone graft have been the gold standard for mandibular defects reconstruction, however, it is
associated with limitation in volume and availability as well as the donor site morbidities. Tissue
engineering approach has been proved to be a good alternative to overcome the limitation of autogenous
bone graft. Tissue engineering studies have been conducted combining various sources of mesenchymal
stem cell, scaffolds, and or signaling molecules. The paper aims to provide information on the
development of bone tissue engineering researches to reconstruct bone defects through results of
numerous studies obtained in the English literature. As the conclusion, bone tissue engineering is a
potential approach to reconstruct maxillofacial bone defects.
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