TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION
TISSUE ENGINEERING IN MAXILLOFACIAL BONE RECONSTRUCTION
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Maxillofacial bone defects due to tumor resection, trauma or infections should be reconstructed to
maintain the bone continuity in order to preserve its masticatory, speech and esthetic functions.
Autogenous bone graft have been the gold standard for mandibular defects reconstruction, however, it is
associated with limitation in volume and availability as well as the donor site morbidities. Tissue
engineering approach has been proved to be a good alternative to overcome the limitation of autogenous
bone graft. Tissue engineering studies have been conducted combining various sources of mesenchymal
stem cell, scaffolds, and or signaling molecules. The paper aims to provide information on the
development of bone tissue engineering researches to reconstruct bone defects through results of
numerous studies obtained in the English literature. As the conclusion, bone tissue engineering is a
potential approach to reconstruct maxillofacial bone defects.
Arrington, E.D., Smith, W.J., Chambers, H.G., Bucknell, A.L. and Davino, N.A. complications of Iliac CrestBone Graft Harvesting. Clinical Orthopaedics and Related Research, 1996, 329: 300-09.http://dx.doi.org/10.1097/00003086-199608000-00037
Conrad C, Huss R. Adult stem cell lines in regenerative medicine and reconstructive surgery. J Surg Res 2005;124(2):201-8.
Eslaminejad MB, Bagheri F. Tissue Engineering Approach for Reconstructing Bone Defects Using Mesenchymal Stem Cells. Yakhteh Med J., 2009, 11(3): 263-272.
Fassina L, Saino E, De Angelis MG, Magenes G, Benazzo F, Visai L. (2010). Low-Power Ultrasounds as a Tool to Culture Human Osteoblasts inside Cancellous Hydroxyapatite. BioinorgChem Appl. 2010:456240.
He Y, Zhang ZY, Zhu HG, Qiu WL, Jiang XQ, Wei Guo.Experimental study on reconstruction of segmental mandible defects using tissue engineered bone combined bone marrow stromal cells with three-dimensional tricalcium phosphate. The J Craniofac Surg.2007, 18(4):800-5
Heary, R.F., Schlenk, R.P., Sacchieri, T.A., Barone, D. and Brotea, C. Persistent Iliac Crest Donor Site Pain:Independent Outcome Assessment. Neurosurgery, 2002,50: 510-516.
Jafarian M, Eslaminejad MB, Khojasteh A, Mashhadi Abbas F, Dehghan MM, Hassanizadeh R Marrow-derived mesenchymal stem cells directed bone regeneration in the dog mandible: a comparison between biphasic calcium phosphate and natural bone mineral. Oral Surg Oral Med Oral Pathol Oral RadIolEndod.2008. 105: e14-e24.
Kamadjaja, DB, Purwati, Ferdiansyah, Rantam FA. Healing Mechanism and Osteogenic Capacity of Bovine Bone Mineral— Human Amniotic Mesenchymal Stem Celland Autogenous Bone Graft in Critical Size Mandibular Defect. J. Biomedical Science and Engineering, 2015, 8: 733-746. http://dx.doi.org/10.4236/jbise.2015.810070
Kuznetsov SA, Huang KE, Marshall GW, Robey PG, Mankani MH. Long-term stable canine mandibular augmentation using autologous bone marrow stromal cells and hydroxyapatite/tricalcium phosphate. Biomaterials 29 (2008): 4211–4216
Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-6.
Li Z, Li B. Repair of mandible defect with tissue engineering in rabbits. ANZ J. Surg. 2008. 75: 1017-1021
Patil AS, Merchant Y, Nagarajan P. Tissue engineering of craniofacial tissues – A review. J Regen Med Tissue Eng 2013;2:6.
Purwati A, Ferdiansyah, M. Nasronudin, FA Rantam. Stem cell exploration. Methods of isolation and culture. Airlangga University Press, 2009
Quarto R, Kutepov SM, Kon E (2001). Repair of large bone defects with the use of autologous bone marrow stromal cells. N Eng J Med; 344:385-386
Rai R, Raval R, Khandeparker RVS, Chidrawar SK, Khan AA,Ganpat MS. Tissue Engineering: Step Ahead in Maxillofacial Reconstructiion. Journal of International Oral Health 2015;7(9):138-142
Roberts R, Gallagher J, Spooncer E, Allen TD, Bloomfield F, Dexter TM. Heparansulphate bound growth factors: A mechanism for stromal cell mediated haemopoiesis. Nature 1988;332(6162):376-8.
Schnaper HW, Kleinman HK. Regulation of cell function by extracellular matrix. PediatrNephrol 1993;7(1):96-104.
Srisuwan T, Tilkorn DJ, Wilson JL, Morrison WA, Messer HM, Thompson EW, et al. Molecular aspects of tissue engineering in the dental field. Periodontol 2000;41:88-108.
Susarla SM, Swanson E, Gordon CR. Craniomaxillofacial reconstruction using allotransplantation and tissue engineering: Challenges, opportunities, and potential synergy. Ann PlastSurg 2011;67(6):655-61.
Ward BB, Brown SE, Krebsbach PH. Bioengineering strategies for regeneration of craniofacial bone: A review of emerging technologies. Oral Dis 2010;16(8):709-16.
Yuan J, Cui L, Zhang WJ, Liu W, Cao YL. (2007). Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta tricalcium phosphate. Biomaterials. 28:1005-1013
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