Profile of Endometrial Cancer Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Downloads
Highlights:
1. Endometrial cancer is one of the most common cancers that affect the female genitalia.
2. Endometrial cancer patients are mostly women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II.
Abstract
Introduction: Endometrial cancer is one of the most common cancers that affect the female genitalia. This study aimed to find the profile of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020.
Methods: Data were collected from medical records of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020. There were 154 endometrial cancer patients, and 66 met the inclusion and exclusion criteria. Forty-one of those patients also had curettage grades. Data were extracted from the medical records of those patients.
Results: There were 66 samples used in this study. The most common age group of patients was the age group of 51-60 years old (40.91%). The highest parity rate was nullipara (28.79%). The highest body mass index (BMI) group was the normal BMI group (42.42%). The most common type of endometrial cancer was type 1, with endometrioid adenocarcinoma (93.94%). The most common stage of endometrial cancer was stage II (36.36%). The similarity between curettage and post-operative grade was 70.73%. Patients with a history of diabetes mellitus were 6.06%, and patients with a history of hypertension were 12.12%.
Conclusion: Most of the endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, were women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II. Most patients had similar curettage and post-operative grades, and only a minority had diabetes mellitus and hypertension histories.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209–249.
Suarez AA, Felix AS, Cohn DE. Bokhman Redux: Endometrial Cancer ‘Types’ in the 21st Century. Gynecol Oncology 2017; 144: 243–249.
Casey MJ, Crotzer D. Endometrial Cancer. StatPearls Publishing, 2019.
Zhou Q, Singh S, Tina S, et al. The Pathways in Endometrial Carcinogenesis and an Overview of its Histology, Grade and Stage. Ann Clin Lab Res; 06. Epub ahead of print 1 January 2018.
World Health Organization (WHO). Female Genital Tumours. Geneva, https://publications.iarc.fr/592 (2020).
Soslow RA, Tornos C, Park KJ, et al. Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists. Int J Gynecol Pathol 2019; 38 Suppl 1: S64–S74.
McCluggage WG. Pathologic Staging of Endometrial Carcinomas: Selected Areas of Difficulty. Adv Anat Pathol 2018; 25: 71–84.
Inal ZO, Inal HA, Kucukosmanoglu I, et al. Assessment of Endometrial Sampling and Histopathological Results: Analysis of 4,247 Cases. Eurasian J Med 2017; 49: 44–47.
Jones ER, O’Flynn H, Njoku K, et al. Detecting Endometrial Cancer. Obstet Gynaecol 2021; 23: 103–112.
Gupta D. Clinical Behavior and Treatment of Endometrial Cancer. Adv Exp Med Biol 2017; 943: 47–74.
Dewanto RR, Munir RS, Djuari L. Manajemen Penderita Hipertensi di Puskesmas Pacar Keling 18-31 Mei 2015. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2017; 9: 54–59.
Sofyan N, Sudiana IK, Askandar B. Profile of Endometrial Cancer Patients in the Third Referral Hospital in Surabaya based on Known Risk Factors. Biomol Heal Sci J 2020; 3: 67–70.
Sponholtz TR, Palmer JR, Rosenberg L, et al. Reproductive Factors and Incidence of Endometrial Cancer in U.S. Black Women. Cancer Causes Control 2017; 28: 579–588.
Yang X, Wang J. The Role of Metabolic Syndrome in Endometrial Cancer: A Review. Front Oncol 2019; 9: 744.
Sood A, Lang DK, Kaur R, et al. Relevance of Aromatase Inhibitors in Breast Cancer Treatment. Curr Top Med Chem 2021; 21: 1319–1336.
Weir CB, Jan A. BMI Classification Percentile and Cut Off Points. Treasure Island (FL), 2023.
Passarello K, Kurian S, Villanueva V. Endometrial Cancer: An Overview of Pathophysiology, Management, and Care. Semin Oncol Nurs 2019; 35: 157–165.
Kumar K, Pajai S, Baidya GR, et al. Utility of Saline Infusion Sonohysterography in Gynecology: A Review Article. Cureus 2023; 15: e35424.
Oaknin A, Bosse TJ, Creutzberg CL, et al. Endometrial Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up. Annals of Oncology : Official Journal of the European Society for Medical Oncology 2022; 33: 860–877.
Rahestyningtyas E, Mulawardhana P, Lesmana T. Abdominal Skin Metastasis in Endometrial Cancer. Maj Obstet Ginekol 2019; 27: 84–89.
Tung H-J, Huang H-J, Lai C-H. Adjuvant and Post-Surgical Treatment in Endometrial Cancer. Best Pract Res Clin Obstet Gynaecol 2022; 78: 52–63.
Paramitha Dewi PP, Budiana ING. Profil Pasien Kanker Endometrium di RSUP Sanglah Denpasar Periode Agustus 2012 – Juli 2014. E-Jurnal Med Udayana 2017; 6: 1–7.
Peacock K, Ketvertis KM, Doerr C. Menopause (Nursing). Treasure Island (FL), 2023.
Mirhalina S. Jenis dan Faktor Risiko Kanker Endometrium di Rumah Sakit dr Pirngadi Kota Medan Tahun 2015-2018. J Pandu Husada 2020; 1: 184–188.
Jayawickcrama WIU, Abeysena C. Risk Factors for Endometrial Carcinoma among Postmenopausal Women in Sri Lanka: A Case Control Study. BMC Public Health 2019; 19: 1387.
Yuana E, Silitonga HA, Fauzi TM. Hubungan Indeks Massa Tubuh dan Jumlah Paritas dengan Tipe-Tipe Kanker Endometrium. J Kedokt Methodist 2021; 14: 1–11.
Putri SSAKGNAWDSHN. Profil Penderita Kanker Endometrium di RSUP Dr. Hasan Sadikin Bandung Periode Tahun 2017-2020. Indones J Obstet Gynecol Sci 2022; 234–243.
Helmanda YYS. Factors Related to Type of Endometrial Cancer in RSUP Dr. M. Djamil Padang. Indones J Obstet Gynecol Sci 2019; 157–165.
Rosdiana YE, Sandhika W. The Difference of PGE2 and COX-2 Expressions in Various Histological Grading of Endometrial Endometrioid Carcinoma. Maj Obstet Ginekol 2018; 25: 1–5.
Lago V, Martín B, Ballesteros E, et al. Tumor Grade Correlation between Preoperative Biopsy and Final Surgical Specimen in Endometrial Cancer: The Use of Different Diagnostic Methods and Analysis of Associated Factors. Int J Gynecol Cancer 2018; 28: 1258–1263.
Adha AZNA, I’tishom R, Rizaldi F, et al. Profile of Diabetes Mellitus in Benign Protate Hyperplation’s Patients with Urinary Retention in Dr. Soetomo 2016. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2019; 10: 71–74.
Aune D, Sen A, Vatten LJ. Hypertension and the Risk of Endometrial Cancer: A Systematic Review and Meta-Analysis of Case-Control and Cohort Studies. Sci Rep 2017; 7: 44808.
Copyright (c) 2023 Kenny Dion Alim, Brahmana Askandar Tjokroprawiro, Etty Hary Kusumastuti
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The formal legal aspect of journal publication accessibility refers to Creative Commons Atribution-Share Alike 4.0 (CC BY-SA).
