Urinalysis Profile of Dengue Viral Infection Patients in Dr. Soetomo General Academic Hospital, Surabaya, from 2019-2021
Downloads
Highlights:
1. Dengue viral infection patients were mostly male and aged 17-45 years old.
2. Dengue viral infection patients mostly have normal urinalysis results.
3. Some dengue viral infection patients can have elevated protein, blood, bilirubin, urobilinogen, leukocytes esterase, and ketones in the urine.
Abstract
Introduction: Dengue viral infection is still a burden in Indonesia. It often causes some kidney complications such as acute renal failure, proteinuria, hematuria, and glomerulonephritis. Urinalysis is an easy and useful examination of kidney complications. This study aimed to discover the most common profile of urinalysis in dengue viral infection.
Methods: This study used a cross-sectional method with medical records data of patients with dengue viral infection in Dr. Soetomo General Academic Hospital, Surabaya, in the 2019-2021 period. Purposive sampling techniques were used with inclusion and exclusion criteria. Data such as age, gender, dengue viral infection severity level, and dipstick urinalysis results were taken and analyzed using descriptive analysis in SPSS Statistics 25.
Results: A total of 276 patients were included. The sample was dominated by male patients (52.9%) and patients aged 17-45 years old (40.2%). Most patients suffered from dengue hemorrhagic fever/DHF (54.3%) followed by dengue fever (45.7%). DHF was categorized into grade I (28.3%), grade II (13.4%), grade III (8.3%), and grade IV (4.3%). Most urinalysis results were normal and followed by increased results of protein, blood/hemoglobin, bilirubin, urobilinogen, leukocytes esterase, and ketones in some patients.
Conclusion: Dengue viral infection was more common in male patients and 17-45 years old patients. The most common diagnosis was DHF. Urinalysis results in dengue viral infection were mostly normal. Follow-up research is needed to find the relation between the elevated urinalysis results and the severity of dengue viral infection.
Kalayanarooj S, Vaughn DW, Nimmannitya S, et al. Early Clinical and Laboratory Indicators of Acute Dengue Illness. J Infect Dis 1997; 176: 313–321.
Asia WHORO for S-E. Comprehensive Guideline for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. Revised and expanded edition. New Delhi PP - New Delhi: WHO Regional Office for South-East Asia, https://apps.who.int/iris/handle/10665/204894 (2011).
World Health Organization (WHO). Dengue and Severe Dengue. Geneva, https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue (2022).
Harapan H, Michie A, Mudatsir M, et al. Epidemiology of Dengue Hemorrhagic Fever in Indonesia: Analysis of Five Decades Data from the National Disease Surveillance. BMC Res Notes 2019; 12: 350.
E. MBE, Penelope K, E. OADM. Dengue Virus Pathogenesis: an Integrated View. Clin Microbiol Rev 2009; 22: 564–581.
Poltronieri P, Sun B, Mallardo M. RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load. Curr Genomics 2015; 16: 327–335.
Chuansumrit A, Tangnararatchakit K. Pathophysiology and Management of Dengue Hemorrhagic Fever. Transfus Altern Transfus Med 2006; 8: 3–11.
Soegijanto S, Sucipto TH, Mulyatno KC, et al. Epidemiology Study of Dengue Virus in Surabaya, Bogor, and Bangkalan, Indonesia 2008-2018. Folia Medica Indones 2020; 56: 296–301.
Laily FI, Rossyanti L, Sulistiawati S. The Effect of DHF Education on DHF Prevention Knowledge of 5th and 6th Grade Students of SDN Purwotengah II Mojokerto. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2020; 11: 51–55.
Vachvanichsanong P, Thisyakorn U, Thisyakorn C. Dengue Hemorrhagic Fever and the Kidney. Arch Virol; 161. Epub ahead of print 1 April 2016.
Lizarraga KJ, Nayer A. Dengue-Associated Kidney Disease. J Nephropathol 2014; 3: 57–62.
Simerville JA, Maxted WC, Pahira JJ. Urinalysis: A Comprehensive Review. Am Fam Physician 2005; 71: 1153–1162.
Raymond JR, Yarger WE. Abnormal Urine Color: Differential Diagnosis. South Med J 1988; 81: 837–841.
McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book. Elsevier Health Sciences, https://books.google.co.id/books?id=xAzhCwAAQBAJ (2017).
Liao JC, Churchill BM. Pediatric Urine Testing. Pediatr Clin North Am 2001; 48: 1425–40; vii–viii.
Haroon M, Jan H, Faisal S, et al. Dengue Outbreak in Peshawar: Clinical Features and Laboratory Markers of Dengue Virus Infection. J Infect Public Health 2019; 12: 258–262.
Atique S, Chan T-C, Chen C-C, et al. Investigating Spatio-Temporal Distribution and Diffusion Patterns of the Dengue Outbreak in Swat, Pakistan. J Infect Public Health 2018; 11: 550–557.
Hsu JC, Hsieh C-L, Lu CY. Trend and Geographic Analysis of the Prevalence of Dengue in Taiwan, 2010–2015. Int J Infect Dis 2017; 54: 43–49.
Puspitasari D, Dewi S, Aryati A. The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection. J Ners 2017; 8: 41–46.
Vincent A, Bramantono B, Hadi U, et al. Expanded Dengue Syndrome. Curr Intern Med Res Pract Surabaya J 2022; 3: 26–32.
Smith DS. Dengue. Medscape, https://emedicine.medscape.com/article/215840-overview?form=fpf (2019, accessed 13 June 2021).
Mallhi TH, Sarriff A, Adnan AS, et al. Dengue-Induced Acute Kidney Injury (DAKI): A Neglected and Fatal Complication of Dengue Viral Infection--A Systematic Review. J Coll Physicians Surg Pak 2015; 25: 828–834.
Jayawinata M, Rusli M, Yotopranoto S. Hubungan Perubahan Jumlah Leukosit dengan Derajat Klinik Penderita Rawat Inap DBD Dewasa. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2017; 9: 14–19.
Permatasari DY, Ramaningrum G, Novitasari A. Hubungan Status Gizi, Umur, dan Jenis Kelamin dengan Derajat Infeksi Dengue pada Anak. J Kedokt Muhammadiyah 2013; 2: 24–28.
Lumpaopong A, Kaewplang P, Watanaveeradej V, et al. Electrolyte Disturbances and Abnormal Urine Analysis in Children with Dengue Infection. Southeast Asian J Trop Med Public Health 2010; 41: 72–76.
Nunthanid S, Tiawilai A. Dengue Patients at Photharam Hospital: A Clinical Trial Site of Dengue Vaccine. Southeast Asian J Trop Med Public Health 2015; 46 Suppl 1: 11–16.
Vachvanichsanong P, McNeil E. Electrolyte Disturbance and Kidney Dysfunction in Dengue Viral Infection. Southeast Asian J Trop Med Public Health 2015; 46 Suppl 1: 108–117.
D'Amico G, Bazzi C. Pathophysiology of Proteinuria. Kidney Int 2003; 63: 809–825.
Copyright (c) 2023 Albertus Reiner Rahardjo, Puspa Wardhani
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The formal legal aspect of journal publication accessibility refers to Creative Commons Atribution-Share Alike 4.0 (CC BY-SA).