Risk Factor Pattern of Graves’ Ophthalmopathy at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
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Highlights:
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Female patients are more likely to suffer from GO.
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Most GO patients have high thyroid levels (hypothyroidism).
Abstract
Introduction: Graves' ophthalmopathy (GO) is an autoimmune condition that extends beyond the thyroid gland. The development of GO may be influenced by various risk factors, some of which may interact with each other. This study aimed to identify the most prevalent risk factors for patients with GO from 2019 to 2022 at Dr. Soetomo General Academic Hospital, Surabaya.
Methods: This study employed a descriptive cross-sectional design, examining 150 patients who met the inclusion and exclusion criteria. This study measured the age, gender, and systemic thyroid status of all patients. This study used Microsoft Word and Microsoft Excel for Mac version 16.87 to process data.
Results: Between 2019 and 2022, 150 patients were diagnosed with GO at Dr. Soetomo General Academic Hospital, Surabaya. The condition was more prevalent in females than males, and the most common age group affected was between 30 and 50 years old. Additionally, 72% of patients with GO also had hyperthyroidism.
Conclusion: Graves' ophthalmopathy was more prevalent in female patients, aged between 30 and 50 years old, with the majority having hyperthyroidism. Future studies should be conducted on the patterns of GO risk factors on a larger scale to more accurately represent the disease in the general population.
Nugroho W. YA, Limantoro C, Arimadyo AK. Hubungan Faktor Risiko terhadap Kejadian Ophthalmopathy Graves. J Kedokt Diponegoro (Diponegoro Med Journal) 2019; 8: 1248–1256. [Journal]
Davies TF, Andersen S, Latif R, Nagayama Y, Barbesino G, Brito M, et al. Graves’ Disease. Nat Rev Dis Prim 2020; 6: 52. [Journal]
Ginting HK, Adi S. A Case of Thyrotoxic Periodic Paralysis and Moderate to Severe Grave’s Ophthalmopathy Requiring Intravenous Steroid Therapy with a Comorbidity of Chronic Hepatitis B Infection. Curr Intern Med Res Pract Surabaya J 2022; 3: 47–53. [Journal]
Antonelli A, Ferrari SM, Ragusa F, Elia G, Paparo SR, Ruffilli I, et al. Graves’ Disease: Epidemiology, Genetic and Environmental Risk Factors and Viruses. Best Pract Res Clin Endocrinol Metab 2020; 34: 101387. [ScienceDirect]
Ehlers M, Schott M, Allelein S. Graves, Disease in Clinical Perspective. FBL 2019; 24: 33–45. [Journal]
Eshraghi B, Pourazizi M, Abbasi M, Mohammadbeigy I. Hypo vs. Hyperthyroid Eye Disease: Is There Any Difference? BMC Ophthalmol 2023; 23: 58. [Journal]
Cao J, Su Y, Chen Z, Ma C, Xiong W. The Risk Factors for Graves’ Ophthalmopathy. Graefe’s Arch Clin Exp Ophthalmol 2022; 260: 1043–1054. [Springer]
Łacheta D, Miśkiewicz P, Głuszko A, Nowicka G, Struga M, Kantor I, et al. Immunological Aspects of Graves’ Ophthalmopathy. Biomed Res Int 2019; 2019: 7453260. [Journal]
Bartalena L, Piantanida E, Gallo D, Lai A, Tanda ML. Epidemiology, Natural History, Risk Factors, and Prevention of Graves’ Orbitopathy. Front Endocrinol (Lausanne); 11, (2020). [Journal]
Stasiak M, Zawadzka-Starczewska K, Tymoniuk B, Stasiak B, Lewiński A. Associations between Lipid Profiles and Graves’ Orbitopathy can be HLA-Dependent. Genes; 14. 2023. [Journal]
Ferrari SM, Fallahi P, Ruffilli I, Elia G, Ragusa F, Benvenga S, et al. The Association of Other Autoimmune Diseases in Patients with Graves’ Disease (with or without Ophthalmopathy): Review of the Literature and Report of a Large Series. Autoimmun Rev 2019; 18: 287–292. [ScienceDirect]
Siedlecki SL. Understanding Descriptive Research Designs and Methods. Clin Nurse Spec; 34, (2020). [Journal]
Hunziker S, Blankenagel M. Cross-Sectional Research Design. In: Hunziker S, Blankenagel M (eds) Research Design in Business and Management: A Practical Guide for Students and Researchers. Wiesbaden: Springer Fachmedien Wiesbaden, pp. 187–199. [Book Chapter]
Azwinda F, Djuari L, Soegiarto G. An Overview of Knowledge Level Regarding the Systemic Lupus Erythematosus (SLE) in People with Lupus (Odapus). Indones J Public Heal 2022; 17: 406–417. [Journal]
Mulya FD. Analisis Faktor Risiko Kejadian Ophthalmopathy Graves di RSUP Dr. Mohammad Hoesin Palembang Periode 2018-2021, Faculty of Medicine Universitas Sriwijaya Palembang (2021). [Website]
Piya S, Gurung J, Khatri A. Thyroid Function Status in Patients with Thyroid Associated Ophthalmopathy: A Study for Nepal. J Diabetes Endocrinol Assoc Nepal 2019; 3: 3–9. [Journal]
Deng B, Yuan Y, Zhong M, Ren R, Deng W, Duan X. The Relationship between Metabolic Parameters, Age, and Thyroid Status: A Cross-Sectional Study-Based National Survey of Iodine Nutrition, Thyroid Disease. Risk Manag Healthc Policy 2021; 14: 1723–1730. [PubMed]
Kocełak P, Mossakowska M, Puzianowska-Kuźnicka M, Sworczak K, Wyszomirski A, Handzlik G, et al. Prevalence and Risk Factors of Untreated Thyroid Dysfunctions in the Older Caucasian Adults: Results of PolSenior 2 Survey. PLoS One 2022; 17: e0272045. [Journal]
Tariq M, Abid S, Umar S, Naz H, Hameed J, Madiha M, et al. Unravelling the Relationship between Smoking and Thyroid Stimulating Hormone: How Tobacco Use Alter Thyroid. J Popul Ther Clin Pharmacol 2024; Vol. 31: 142–148. [Journal]
Chen X, Zheng X, Ding Z, Su Y, Wang S, Cui B, et al. Relationship of Gender and Age on Thyroid Hormone Parameters in a Large Chinese Population. Arch Endocrinol Metab 2020; 64: 52–58. [Journal]
Wardana RCA, Saraswati MR, Dwipayana IMP, Gotera W. Karakteristik Pasien Gangguan Fungsi Tiroid di RSUP Sanglah Tahun 2019. E-Jurnal Med Udayana 2023; 12: 65–70. [Journal]
Prajayanti MD. Gambaran Kadar Thyroid Stimulating Hormone pada Pasien Disfungsi Tiroid Di Laboratorium Klinik Niki Diagnostic Center Denpasar. Politeknik Kesehatan Denpasar, (2020). [Website]
Muralidhar A, Das S, Tiple S. Clinical Profile of Thyroid Eye Disease and Factors Predictive of Disease Severity. Indian J Ophthalmol 2020; 68: 1629–1634. [PubMed]
Muñoz-Ortiz J, Sierra-Cote MC, Zapata-Bravo E, Valenzuela-Vallejo L, Marin-Noriega MA, Uribe-Reina P, et al. Prevalence of Hyperthyroidism, Hypothyroidism, and Euthyroidism in Thyroid Eye Disease: A Systematic Review of the Literature. Syst Rev 2020; 9: 201. [Journal]
Suzuki N, Inoue K, Yoshimura R, Kinoshita A, Suzuki A, Fukushita M, et al. The Mediation Role of Thyrotropin Receptor Antibody in the Relationship between Age and Severity of Hyperthyroidism in Graves’ Disease. Thyroid® 2022; 32: 1243–1248. [Journal]
Razvi S, Ryan V, Ingoe L, Pearce SH, Wilkes S. Age-Related Serum Thyroid-Stimulating Hormone Reference Range in Older Patients Treated with Levothyroxine: A Randomized Controlled Feasibility Trial (SORTED 1). Eur Thyroid J 2020; 9: 40–48. [Journal]
Rejeki PS, Prasetya RE. Aging. Surabaya: Airlangga University Press, 2022. [Book]
Xie H, Chen D, Zhang J, Yang R, Gu W, Wang X. Characteristics of Graves’ Disease in Children and Adolescents in Nanjing: A Retrospective Investigation Study. Front Public Heal 2022; 10: 993733. [PubMed]
Yin X, Lu C, Sun D, Ji Y, Wang Y, Zheng H, et al. Stimulating Thyroglobulin to TSH Ratio Predict Long-Term Efficacy of 131I Therapy in Patients with Differentiated Tthyroid Cancer after Total Thyroidectomy: A Retrospective Study. Endocrine 2024; 84: 1064–1071. [Springer]
Castello R, Caputo M. Thyroid Diseases and Gender. Ital J Gender-Specific Med 2019; 5: 136–141. [Journal]
Fang T, Lin L, Ou Q, Lin L, Zhang H, Chen K, et al. An Investigation on the Risk Factors of Thyroid Diseases in Community Population in Hainan. Int J Endocrinol 2022; 2022: 4514538. [Journal]
Yang M, Cao S. Gender and Age-Specific Differences in the Association of Thyroid Function and Hyperuricemia in Chinese: A Cross-Sectional Study. Int J Endocrinol 2022; 2022: 2168039. [Journal]
Gavina C, Araújo F, Teixeira C, Ruivo JA, Corte-Real AL, Luz-Duarte L, et al. Sex Differences in LDL-C Control in A Primary Care Population: The PORTRAIT-DYS Study. Atherosclerosis 2023; 384: 117148. [Journal]
Febrianto D, Novida H. Diagnostic and Management Problems of Hyperthyroidism in a Patient with Testicular Seminoma. Curr Intern Med Res Pract Surabaya J 2022; 3: 16–21. [Journal]
Nisa AI, Awalia A, Nugraha J. Response and Side Effects from Rheumatoid Arthritis Therapy at Dr. Soetomo General Hospital Surabaya 2017. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2022; 13: 9–12. [Journal]
Armando B, Setiawati R, Edward M, Mustokoweni S. Conventional Radiological Profile of Metastatic Bone Disease Based on Its Histopathological Results: A 3-Year Experience. JUXTA J Ilm Mhs Kedokt Univ Airlangga 2023; 14: 76–82. [Journal]
Hamadi GM. Article Review: Immunological Markers Related with Thyroidisum. Int J Res Appl Sci Biotechnol 2022; 9: 19–32. [Journal]
Pokhrel B, Bhusal K. Graves Disease. Treasure Island (FL), 2025. [PubMed]
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