Perbedaan Kadar IL-10 pada Preeklampsia Tipe Dini dan Lambat
Downloads
Tujuan: Menganalisis perbedaan kadar IL-10 antara preeklamp-sia tipe dini dan preeklampsia tipe lambat.
Bahan dan Metode: Penelitian ini melibatkan 56 wanita hamil yang terbagi menjadi empat kelompok, yaitu wanita hamil normal usia kehamilan 30-34 minggu, wanita hamil normal usia > 34 minggu, preeklampsia berat tipe dini (30-34 minggu), preeklampsia berat tipe lambat (> 34minggu). Pemeriksaan IL-10 dilakukan saat penderita masuk rumah sakit dan didiagnosis sebagai preeklampsia dengan menggunakan metode ELISA
Hasil: Rerata kadar IL-10 pada kelompok preeklampsia tipe dini (0,37 ± 0,14) lebih rendah dibandingkan kelompok preeklampsia tipe lambat (0,87 ± 0,43) dengan P<0,001. Rerata kadar IL-10 pada kelompok preeklampsia tipe dini (0,37 ± 0,14) lebih rendah dibandingkan kelompok wanita hamil normal usia 30 -34 minggu (0,84 ± 0,42) dengan P<0,001. Tidak didapatkan perbedaan rerata kadar IL-10 pada kelompok preeklampsia tipe lambat (0,87 ± 0,43) dibandingkan kelompok wanita hamil normal usia > 34minggu (0,75 ± 0,68) P=0,22.
Simpulan: Keadaan inflamasi berat terjadi pada preeklampsia berat tipe dini.
Raghupathy R. Cytokines as Key Players in the Pathophysiology of Preeclampsia. Medical Prin-ciples and Practice. 2013;22:8-19.
Matthiesen L, Berg G, Ernerudh J, Ekerfelt C, Jonsson Y, Sharma S. Immunology of preeclamp-sia. Chem Immunol Allergy. 2005;89:49-61.
Bayram M, Bostanci MS, Celtemen MB, Bagrlaclk EU, Yaman M, Civil F. Evaluation the Levels of Plasma Interleukins (IL-8, IFN-ï§, IL-10) in Preeclamptic Pregnancies. Baghdad Science Journal. 2012;8(4).
Cunningham F, Leveno K, Bloom S, Spong C, Dashe J, Hoffman B, et al. Williams Obstetrics. 24th ed. New York: McGraw-Hill Education; 2014
Thaxton JE, Sharma S. Interleukin-10: Multi-Faced Agent of Pregnancy. American Journal of Repro-ductive Immunology. 2010;63:482-91.
Redman C, Sargent I, Borzychowski AM. Inflammation and Preeclampsia. Seminars in Fetal and Neonatal Medicine. 2006;11:309-16.
Madazli R, Yuksel MA, Imamoglu M, et al. Comparison of Clinical and Perinatal Outcome in Early- and Late-Onset Preeclampsia. Archives of gynecology and Obstetrics. 2014:1:53-7.
Ornaghi S, Tyurmorezova A, Alegri P, et al. Influencing Factors for Late-onset Preeclampsia. Journal of Maternal-Fetal and Neonatal Medicine. 2013;26(13):1299-302.
Dadelszen PV, Magee LA, Robert JM. Sub-classification of preeclampsia. Hypertension in Pregnancy. 2003;22(2):143-8.
Sibai BM. Maternal and Uteroplacental Hemo-dynamic for the Classification and Prediction of Preeclampsia. Journal of the American Heart Association. Hypertension. 2008;52:805-6.
Lamminpaa R, Julkunen KV, Gissler M, Heinonen S. Preeclampsia Complicated by Advance Maternal Age: a Registry-Based Study on Primiparous Women in Finland 1997-2008. BMC Pregnancy and Childbirth. 2012;12(47).
Baeten JM, Bukusi EA, Lambe M. Pregnancy Complications and Outcomes Among Overweight and Obese Nulliparous Women. American Journal of Public Health. 2001;91(3).
Ferrazzi E, Stampalija T, Aupont JE. The Evidence for Late-onset Preeclampsia As a Maternogenic Disease of Pregnancy. Fetal and Maternal Medicine Review. 2013;24(1):18-31
Kalkunte S, Nevers T, Norris WE, Sharma S. Vascular IL-10: A Protective Role in Preeclampsia. Journal Reproduction Immunology. 2011;88(2): 165-9.
Thaxton JE, Sharma S. Interleukin-10: A Multi-faced Agent of Pregnancy. American Journal of Reproductive Immunology. 2010;63:482-91.
Bayram M, Bostanci MS, Celtemen MB, Bagrlaclk EU, Yaman M, Civil F. Inflammatory Response in Severe Preeclamptic and Preeclamptic Pregnancies. J Clin Gynecol Obstet. 2012;1(2,3):40-5.
Eiland E, Nzerue C, Faulkner M. Preeclampsia. Journal of Pregnancy. Hidawi Publishing Corporat-ion. 2012;12.
1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
