Higher IL-1beta level in the follicular liquid of endometriosis compared with non-endometriosis patients
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Objective: To ascertain the IL-1b level in the follicular liquid of endometriosis sufferers compared with that of non-endometriosis sufferers.
Materials and Methods: The ELISA method, for detecting the IL-1b, is taken from follicular fluid of endometriosis as well as non-endometriosis patients that diagnosed according to the ASRM criteria.
Results: The 54 subjects were dominantly endometriosis <34 year old (88.9%). The IL-1b levels of endometriosis patients and non-endometriosis patients were 82.86 ± 30.15 and 56.05 ± 23.27 respectively (p=0.01). The ROC value of IL-1b was found at a cut-off point of 26 (with the IL-1b cut-off point of 65.16). The discriminating value of AUC (area under curve) was 59.3%.
Conclusion: It was concluded that the IL-1b level in endometriosis is higher than that in non- endometriosis.Amer S. Obstetrics, gynaecology and reproductive medicine. Endometriosis. 2008;18(5):126–33.
Burney RO. Pathogenesis and pathophysiology of endometriosis’, Fertility and Sterility. 2002;98(3): 511–9.
Harada T and Iwabe T. Role of cytokines in endo-metriosis. Fertility and Ssterility. 2001;76(1): 1–10.
Lebovic DI and Mueller MD. Immunobiology of endometriosis’, Fertility and Sterility. 2001;76(1): 1–10.
Alpay Z and Saed GM. Female infertility and free radicals: potential role in adhesions and endome-triosis. Journal of Society for Gynecologic Inves-tigation. 2006;13(6): 390–8.
Gerald N, Caillaud M, Martoriati A, et al. The interleukin-1 system and female reproduction’, The Journal of Endocrinology. 2004;180(2):203–12.
Kim H, Ku SY, Kim SH et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis. Human Reproduction. 2009;24(10):2656–9.
Hadisaputra WPS. Serum biomarker profiles of interleukin-6, tumor necrosis factor alpha, matrix-metalloproteinase-2, and vascular edhothelial growth factor in endometriosis staging’, Med J Indones. 2013;22(2):76–82.
Gupta S, Agarwal A, Krajcir NA. Role of oxidative stress in endometriosis. Reprod Biomed Online. 2006;3(1):126–34.
Pellicer A, Rubio C, Vidal F et al. In vitro fertil-ization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplant-ation embryos. Fertility and Sterility. 2009;71(6): 1033–9.
Lucena E. Immune abnormalities in endometriosis compromising fertility in IVT-ET patients. The Journal of Reproductive Medicine. 2009;44(5): 458–64.
Kyama CM, Overbergh L, Mihalyi A et al. Effect of recombinant human TNF-binding protein-1 and GnRH antagonist on mRNA expression of inflam-matory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons. Fertility and Sterility. 2008;89(5): 1306–13.
Opøien HK, Fedorcsak P, Omland AK et al. In vitro fertilization is a successful treatment in endo-metriosis-associated infertility. Fertility and Sterility. 2012;97(4), 912–8.
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