Differences in cytotoxicity between 5% tetracycline hydrochloride and 15% EDTA as root canal irrigant

cytotoxicity 5% tetracycline hydrochloride 15% EDTA fibroblast

Authors

  • Devi Eka Juniarti
    dental_journal@yahoo.com
    Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia
  • Karlina Samadi Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia
  • Achmad Sudirman Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Indonesia
June 1, 2008

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5% tetracycline hydrochloride and 15% EDTA as a root canal irrigant have been proven to be able to remove smear layer, open dentinal tubules and have antimicrobial activity. An effective root canal irrigation solution must be able to dissolve organic and anorganic debris, lubricate endodontic instruments, disinfect microorganism and non toxic. The purpose of this laboratory experimental study was to determine cytotoxicity differences between 5% tetracycline hydrochloride and 15% EDTA. 21 samples were used and classified into 3 groups: control, 5% tetracycline hydrochloride and 15% EDTA groups. Cytotoxicity test was done using BHK21 cells. The data was analyzed using Bird and Forrester formula. It concluded that 5% tetracycline hydrochloride more toxic than 15% EDTA as a root canal irrigant.

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