Efikasi Seramid, Mentol, dan Polidokanol dibandingkan Jeli Petrolatum terhadap Keparahan Dermatitis Atopik Ringan

Dewi Nurasrifah, Menul Ayu Umborowati, Diah Mira Indramaya, Iskandar Zulkarnain, Cita Rosita Sigit Prakoeswa

= http://dx.doi.org/10.20473/bikk.V31.2.2019.91-97
Abstract views = 46 times | views = 25 times

Abstract


Latar Belakang: Dermatitis atopik (DA) adalah penyakit kompleks dengan gejala klinis berspektrum luas. Penyakit ini ditandai dengan gejala gatal yang dominan sampai dapat mengganggu kualitas tidur, dan dapat menyebabkan infeksi sekunder. Patogenesis DA meliputi gangguan sawar kulit, faktor lingkungan, agen infeksius, dan abnormalitas sistem imun. Gangguan sawar kulit menjadi faktor utama yang harus diperbaiki salah satunya dengan pemberian pelembap seawal mungkin. Tujuan: Membandingkan efikasi pelembap yang mengandung seramid, mentol, dan polidokanol dengan jeli petrolatum pada pasien DA derajat ringan. Metode: Penelitian ini merupakan penelitian eksperimental analitik dengan menggunakan metode uji klinis acak terkontrol tersamar tunggal, membandingkan terapi pelembap yang mengandung seramid, polidokanol, dan mentol dengan pelembap jeli petrolatum pada pasien DA anak dan dewasa dengan derajat keparahan ringan yang dinilai melalui indeks scoring of atopic dermatitis (SCORAD). Hasil: Penghitungan nilai SCORAD sebelum dan sesudah intervensi pada kelompok perlakuan atau kontrol memiliki perbedaan yang tidak  signifikan  dengan nilai p>0,05. Simpulan: Pemberian kedua jenis pelembap dapat menurunkan derajat keparahan SCORAD pada pasien DA.


Keywords


seramid; mentol; polidokanol; jeli petrolatum; dermatitis atopik;

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References


Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 2015; 66(1): 8-16.

Rudikoff D, Lee D, Cohen SR. Clinical aspects and differential diagnosis of atopic dermatitis. In: Rudikoff D, Cohen SR, Scheinfeld N, editors. Atopic dermatitis and eczematous disorders. Boca Raton 2014: 39-43.

Sirikudta W, Kulthanan K, Varothal S, Nuchkull P. Moisturizers for patients with atopic dermatitis: an overview. J Allergy Ther 2013; 4: 1-6.

Imokawa G, Ishida K. Role of ceramide in the barrier function of the stratum corneum, implications for the pathogenesis of atopic dermatitis. J Clin Exp Dermatol Res 2014; 5(1): 206.

Yarbrough KB, Neuhaus KL, Simpson EL. The effects of treatment on itch in atopic dermatitis. Dermatol Ther 2013; 26(2): 110-9.

Rossi AB, Nocera T, Lapallud P. Clinical and instrumental efficacy and tolerability of a moisturizing body lotion containing polidocanol and prucidine-4 on reducing pruritus and xerosis. J Am Acad Dermatol 2016; 74(5): AB48.

Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, et al. Diagnosis and treatment of atopic dermatitis in children and adults: european academy of allergology and clinical immunology/american academy of allergy, asthma, and immunology/PRACTALL consensus report. Allergy 2006; 61: 969-87.

Ring J, Alomar A, Bieber T, Deleuran M, Fink-Wagner A, Jelimetti C, et al. Guidelines for treatment of atopic eczema (atopic dermatitis). Jeadv 2012; 26: 1176-93.

Seite S, Bieber T. Barrier function and microbiotic dysbiosis in atopic dermatitis. Clin Cosmet Investig Dermatol 2015; 8: 479-83.

Pereira MP, Ständer S. Assessment of severity and burden of pruritus. Allergol Int 2017; 66: 3-7.

Oranje AP, Glazenburg EJ, Wolerstorfert A, de Waard-van der Spek FB. Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score. Br J Dermatol 2007; 157: 645-8.

Willemsen MG, van Valburg RW, Dirven-Meijer PC, Oranje AP, van der Wouden JC, Moed H. Determining the severity of atopic dermatitis in children presenting in general practice: an easy and fast method. Dermatol Res Pract 2009; 1-6.

Eichenfield LF, Tom WL, Chamlin SL, Feldman SR, Hanifin JM, Simpson EL, et al. Guidelines of care for the management of atopic dermatitis. J Am Acad Dermatol 2013; 1-13.

Milani M. Barrier repair therapy in atopic eczema: new evidences in improving skin functions with topical emoliency and hydration strategies. J Clin Dermatol Ther 2015; 2(011): 1-4.

Hong J, Buddenkotte J, Berger TG, Steinhoff M. Management of itch in atopic dermatitis. Semin Cutan Med Surg 2011; 30(2): 71-86.

Lee JH, Han KD, Kim KM, Park YG, Lee JY, Park YM. Prevalence of atopic dermatitis in Korean children based on data from the 2008-2011 Korean national health and nutrition examination survey. Allergy Asthma Immunol Res 2016; 8: 79-83.

Shaw TE, Currie GP, Koudelka CW, Simpson EL. Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health. J Invest Dermatol 2011; 131: 67-73.

Lee KS, Oh IH, Choi SH, Rha YH. Analysis of epidemiology and risk factors of atopic dermatitis in Korean children and adolescent from the 2010 Korean national health and nutrition examination survey. Biomed Res Int 2017: 1-6.

Somamunt S, Chinratanapisit S, Pacharn P, Visitsunthorn N, Jirapongsananuruk O. The natural history of atopic dermatitis and its association with atopic march. Asian Pac J Allergy Immunol 2017; 35: 137-43.

Thomas IN, Myalil JM. How significant is family history in atopic dermatitis? A study on the role of family history in atopic dermatitis in children in Ahman, United Arab Emirates. Egypt Dermatol Online J 2010; 6; 2(4): 1-6.

Koh MJ, Giam YC, Miew HM, Foong AY, Chong JH, Wong SMY, et al. Comparison of the simple patient-centric atopic dermatitis scoring system PEST with SCORAD in young children using a ceramide dominant therapeutic moisturizer. Dermatol Ther 2017; 7: 383-93.

Hon KLE, Ching GK, Leung TF, Choi CY, Lee KKC, Ng PC. Estimating emollient usage in patients with eczema. Clin Exp Dermatol 2009; 35: 22-6.


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