A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia
Downloads
Background: The prevalence of adverse drug reactions is likely to increase, and it is associated with increased usage of various drugs. Adverse Cutaneous Drug Reaction (ACDR) is the most frequent adverse drug reaction (30–45%). In Indonesia, the study on the prevalence of ACDR is still limited. Purpose: This study investigated the prevalence, clinical features, causative agents, and mortality rate of ACDR with a type-IV hypersensitivity reaction among patients attending the Department of Dermatology and Venereology in Dr. Sardjito Hospital, Yogyakarta. Methods: This retrospective study was conducted examining medical records undertaken for five years (2011–2015). Of 68,375 patients medicated in the Department of Dermatology and Venereology, 397 patients were diagnosed as ACDR with a type-IV hypersensitivity reaction. Detailed history, including age, sex, past history, and family history of drug reaction taken by the patient, were obtained. Patch testing was done wherever feasible. Result: Of 68,375 patients, 397 patients were included in ACDR with type-IV hypersensitivity (0.58%), giving a 5% of mortality rate. The mean age of the patients was 40.42 years (±16.30; range 18 to 89 years). The female to male ratio was 1.1: 1. The Maculopapular rash was the most common ACDR manifestation (50.88%), followed by Stevens-Johnson Syndrome (13.85%), Fixed Drug Eruption (12.85%), and Drug Reaction with Eosinophilia and Systemic Symptoms (10.08%). The most common causative agents were beta-lactam (16.55%), NSAIDs (12.18%), and acetaminophen (8.62%). Conclusion: Prescription of those drugs should be considered carefully so the incidence of ACDR can be reduced.
Beniwal R, Gupta LK, Khare AK, Mittal A, Mehta S, Balai M. Clinical profile and comparison of causality assessment tools in cutaneous adverse drug reactions. Indian Dermatol Online J 2019; 10(1):27–33.
Gonçalo MM. Cutaneous Adverse Drug Reactions: Contributions to Understand Pathophysiologic Mechanisms Involved in Delayed Reactions (Doctoral dissertation). Universidade de Coimbra Portugal.; 2014.
Verma D, Tiwari D, Gupta D, Verma D. Cutaneous adverse drug reactions-a study of clinical patterns, causality, severity and preventability. IOSRJDMS 2014; 13:102– 9.
Iasella CJ, Johnson HJ, Dunn MA. Adverse drug reactions: type A (Intrinsic) or type B (idiosyncratic). Clin Liver Dis 2017; 21(1):73–87.
Sharma R, Dogra D, Dogra N. A study of cutaneous adverse drug reactions at a tertiary center in Jammu, India. Indian Dermatol Online J 2015; 6(3):168–71.
Borch JE, Andersen KE, Bindslev-Jensen C. Cutaneous adverse drug reactions seen at a university hospital department of dermatology. Acta Derm Venerol 2006; 86(6):523–7.
Chatterjee S, Ghosh AP, Barbhuiya J, Dey SK. Adverse cutaneous drug reactions: A one year survey at a dermatology outpatient clinic of a tertiary care hospital. Indian J Pharmacol 2006; 38(6):429.
Prathap P, Elsy M, Ajitha K, Kumar A, George S. Clinical profile of cutaneous adverse drug reactions in a tertiary care centre. IRA-Int J Appl Sci 2016; 3:424–30.
Qayoom S, Bisati S, Manzoor S, Sameem F, Khan K. Adverse cutaneous drug reactions – a clinico-demographic study in a tertiary care teaching hospital of the Kashmir Valley, India. Arch Iran Med 2015; 18:228–33.
Hendriksen LC, van der Linden PD, Lagro- Janssen ALM, van den Bemt PMLA, Siiskonen SJ, Teichert M, et al. Sex differences associated with adverse drug reactions resulting in hospital admissions. Biol Sex Differ 2021; 3:12-34.
Akalu SD, Belavadi NG. Pattern of adverse drug reactions due to antibiotics in a tertiary care hospital. Int J Basic Clin Pharmacol 2017; 6(8):2027–31.
Rademaker M. Do women have more adverse drug reactions?. Am J Clin Dermatol 2001; 2(6):349–51.
Mauvais-Jarvis F, Berthold HK, Campesi I, Carrero J-J, Dakal S, Franconi F, et al. Sex and gender-based pharmacological response to drugs. Pharmacol Rev 2021; 73(2):730–62.
Dubrall D, Just KS, Schmid M, Stingl JC, Sachs B. Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices. BMC Pharmacol Toxicol 2020; 21:25.
Alomar MJ. Factors affecting the development of adverse drug reactions (Review article). Saudi Pharm J SPJ Off Publ Saudi Pharm Soc 2014; 22(2):83–94.
Lavan AH, Gallagher P. Predicting risk of adverse drug reactions in older adults. Ther Adv Drug Saf 2016; 7(1):11–22.
Jung J-W, Cho S-H, Kim K-H, Min K-U, Kang H-R. Clinical features of fixed drug eruption at a tertiary hospital in Korea. Allergy Asthma Immunol Res 2014 ;6(5):415–20.
Singh PK, Kumar MK, Kumar D, Kumar P. Morphological pattern of cutaneous adverse drug reactions due to antiepileptic drugs in Eastern India. J Clin Diagn Res JCDR 2015; 9(1):WC01–3.
Weisser C, Ben-Shoshan M. Immediate and non-immediate allergic reactions to amoxicillin present a diagnostic dilemma: a case series. J Med Case Reports 2016; 10(10):1–5.
Jung IY, Kim JJ, Lee SJ, Kim J, Seong H, Jeong W, et al. Antibiotic-related adverse drug deactions at a tertiary care hospital in South Korea. BioMed Res Int 2017; 4304973.
Park CS, Kang DY, Kang MG, Kim S, Ye YM, Kim SH, et al. Severe cutaneous adverse reactions to antiepileptic drugs: a nationwide registry-based study in Korea. Allergy Asthma Immunol Res 2019; 11(5):709–22.
Jeimy S, Ben-Shoshan M, Abrams EM, Ellis AK, Connors L, Wong T. Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology. Allergy Asthma Clin Immunol 2020; 16(1):95.
Pichler WJ, Yawalkar N, Britschgi M, Depta J, Strasser I, Schmid S, et al. Cellular and molecular pathophysiology of cutaneous drug reactions. Am J Clin Dermatol 2002; 3(4):229–38.
Shamna M, Dilip C, Ajmal M, Linu Mohan P, Shinu C, Jafer CP, et al. A prospective study on adverse drug reactions of antibiotics in a tertiary care hospital. Saudi Pharm J SPJ 2014; 22(4):303–8.
Wibisono Y, Damayanti D. Skin test for cutaneous adverse drug reactions. Berkala Ilmu Kesehatan Kulit dan Kelamin 2020; 32(1):62-9
- Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
- The legal formal aspect of journal publication accessibility refers to Creative Commons Atribusi-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
- The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
